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    LMTK3 lemur tyrosine kinase 3 [ Homo sapiens (human) ]

    Gene ID: 114783, updated on 17-Jun-2019

    Summary

    Official Symbol
    LMTK3provided by HGNC
    Official Full Name
    lemur tyrosine kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:19295
    See related
    Ensembl:ENSG00000142235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LMR3; TYKLM3; PPP1R101
    Expression
    Biased expression in brain (RPKM 7.4), duodenum (RPKM 0.9) and 5 other tissues See more
    Orthologs

    Genomic context

    See LMTK3 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48485271..48513926, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48988528..49016446, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene glutamate rich WD repeat containing 1 Neighboring gene uncharacterized LOC105372430 Neighboring gene potassium voltage-gated channel subfamily J member 14 Neighboring gene cytohesin 2 Neighboring gene Sharpr-MPRA regulatory regions 10218 and 12364 Neighboring gene sulfotransferase family 2B member 1 Neighboring gene family with sequence similarity 83 member E Neighboring gene sperm acrosome associated 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2018-07-25)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated (2018-07-25)

    ClinGen Genome Curation PagePubMed

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1883

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    cellular_component ND
    No biological Data available
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase LMTK3
    Names
    protein phosphatase 1, regulatory subunit 101
    NP_001073903.1
    XP_011524713.1
    XP_011524714.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080434.1NP_001073903.1  serine/threonine-protein kinase LMTK3

      Status: VALIDATED

      Source sequence(s)
      AC008403
      Consensus CDS
      CCDS46136.1
      UniProtKB/TrEMBL
      A0A0A0MQW5
      Related
      ENSP00000270238.3, ENST00000270238.3
      Conserved Domains (2) summary
      smart00221
      Location:162437
      STYKc; Protein kinase; unclassified specificity
      cd14206
      Location:164439
      PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      48485271..48513926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526412.2XP_011524714.1  serine/threonine-protein kinase LMTK3 isoform X2

      Conserved Domains (2) summary
      smart00221
      Location:148423
      STYKc; Protein kinase; unclassified specificity
      cd14206
      Location:150425
      PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3
    2. XM_011526411.2XP_011524713.1  serine/threonine-protein kinase LMTK3 isoform X1

      Related
      ENSP00000497480.1, ENST00000650440.1
      Conserved Domains (2) summary
      smart00221
      Location:159434
      STYKc; Protein kinase; unclassified specificity
      cd14206
      Location:161436
      PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3
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