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    CGB1 chorionic gonadotropin subunit beta 1 [ Homo sapiens (human) ]

    Gene ID: 114335, updated on 15-Jun-2019

    Summary

    Official Symbol
    CGB1provided by HGNC
    Official Full Name
    chorionic gonadotropin subunit beta 1provided by HGNC
    Primary source
    HGNC:HGNC:16721
    See related
    Ensembl:ENSG00000267631 MIM:608823
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward placenta (RPKM 22.7) See more

    Genomic context

    See CGB1 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (49035569..49036934, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49538826..49540191, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene small NF90 (ILF3) associated RNA G2 Neighboring gene chorionic gonadotropin subunit beta 2 Neighboring gene small NF90 (ILF3) associated RNA G1 Neighboring gene neurotrophin 6 beta (pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hormone activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    choriogonadotropin subunit beta variant 1
    Names
    chorionic gonadotropin beta subunit 1
    chorionic gonadotropin, beta polypeptide 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033377.1NP_203695.2  choriogonadotropin subunit beta variant 1 precursor

      See identical proteins and their annotated locations for NP_203695.2

      Status: REVIEWED

      Source sequence(s)
      AC008687
      Consensus CDS
      CCDS12751.2
      UniProtKB/Swiss-Prot
      A6NKQ9
      Related
      ENSP00000301407.6, ENST00000301407.7
      Conserved Domains (1) summary
      smart00068
      Location:23129
      GHB; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      49035569..49036934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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