U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    OIP5 Opa interacting protein 5 [ Homo sapiens (human) ]

    Gene ID: 11339, updated on 8-Dec-2022

    Summary

    Official Symbol
    OIP5provided by HGNC
    Official Full Name
    Opa interacting protein 5provided by HGNC
    Primary source
    HGNC:HGNC:20300
    See related
    Ensembl:ENSG00000104147 MIM:606020; AllianceGenome:HGNC:20300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT86; MIS18B; LINT-25; MIS18beta; hMIS18beta; 5730547N13Rik
    Summary
    The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
    Expression
    Biased expression in testis (RPKM 12.1), bone marrow (RPKM 3.3) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See OIP5 in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41309273..41332591, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39115437..39138755, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41601471..41624789, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 497, pseudogene Neighboring gene exonuclease 3'-5' domain containing 1 Neighboring gene calcineurin like EF-hand protein 1 Neighboring gene OIP5 antisense RNA 1 Neighboring gene nucleolar and spindle associated protein 1 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell communication NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromocenter IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein Mis18-beta
    Names
    LAP2alpha interactor-25
    MIS18 kinetochore protein homolog B
    cancer/testis antigen 86
    opa-interacting protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317860.2NP_001304789.1  protein Mis18-beta isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AW406383, BC015050
      UniProtKB/Swiss-Prot
      O43482
      Related
      ENSP00000452851.1, ENST00000560640.1
      Conserved Domains (1) summary
      pfam03226
      Location:76130
      Yippee-Mis18; Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
    2. NM_007280.2NP_009211.1  protein Mis18-beta isoform 1

      See identical proteins and their annotated locations for NP_009211.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC015050
      Consensus CDS
      CCDS10074.1
      UniProtKB/Swiss-Prot
      O43482, Q96BX7
      UniProtKB/TrEMBL
      A0A024R9N0
      Related
      ENSP00000220514.3, ENST00000220514.8
      Conserved Domains (1) summary
      pfam03226
      Location:76175
      Yippee-Mis18; Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      41309273..41332591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      39115437..39138755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)