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    U2AF2 U2 small nuclear RNA auxiliary factor 2 [ Homo sapiens (human) ]

    Gene ID: 11338, updated on 22-Jan-2023

    Summary

    Official Symbol
    U2AF2provided by HGNC
    Official Full Name
    U2 small nuclear RNA auxiliary factor 2provided by HGNC
    Primary source
    HGNC:HGNC:23156
    See related
    Ensembl:ENSG00000063244 MIM:191318; AllianceGenome:HGNC:23156
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    U2AF65
    Summary
    U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 33.5), appendix (RPKM 33.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See U2AF2 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55655035..55674716)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58750963..58771692)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56166401..56186082)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 581 Neighboring gene zinc finger protein 580 Neighboring gene coiled-coil domain containing 106 Neighboring gene epsin 1 Neighboring gene vomeronasal 1 receptor 106 pseudogene Neighboring gene NLR family pyrin domain containing 9 Neighboring gene RN7SK pseudogene 109

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat upregulates the abundance of U2 small nuclear RNA auxiliary factor 2 (U2AF2) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables molecular function inhibitor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables poly-pyrimidine tract binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables pre-mRNA 3'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables pre-mRNA 3'-splice site binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U2AF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U2AF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U2AF complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of commitment complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of spliceosomal complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    splicing factor U2AF 65 kDa subunit
    Names
    U2 (RNU2) small nuclear RNA auxiliary factor 2
    U2 auxiliary factor 65 kDa subunit
    U2 small nuclear ribonucleoprotein auxiliary factor (65kD)
    U2 snRNP auxiliary factor large subunit
    hU2AF65

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032904.1 RefSeqGene

      Range
      5001..25667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_623

    mRNA and Protein(s)

    1. NM_001012478.2NP_001012496.1  splicing factor U2AF 65 kDa subunit isoform b

      See identical proteins and their annotated locations for NP_001012496.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC008735, BC008740, BC030574
      Consensus CDS
      CCDS46197.1
      UniProtKB/Swiss-Prot
      P26368
      Related
      ENSP00000388475.1, ENST00000450554.6
      Conserved Domains (1) summary
      TIGR01642
      Location:63470
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    2. NM_007279.3NP_009210.1  splicing factor U2AF 65 kDa subunit isoform a

      See identical proteins and their annotated locations for NP_009210.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC008735, BC008740, BC030574, X64044
      Consensus CDS
      CCDS12933.1
      UniProtKB/Swiss-Prot
      P26368, Q96HC5
      Related
      ENSP00000307863.3, ENST00000308924.9
      Conserved Domains (1) summary
      TIGR01642
      Location:63474
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      55655035..55674716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526410.2XP_011524712.1  splicing factor U2AF 65 kDa subunit isoform X1

      Conserved Domains (1) summary
      TIGR01642
      Location:1370
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    2. XM_047438120.1XP_047294076.1  splicing factor U2AF 65 kDa subunit isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      58750963..58771692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)