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    CHRM5 cholinergic receptor muscarinic 5 [ Homo sapiens (human) ]

    Gene ID: 1133, updated on 15-Jun-2019

    Summary

    Official Symbol
    CHRM5provided by HGNC
    Official Full Name
    cholinergic receptor muscarinic 5provided by HGNC
    Primary source
    HGNC:HGNC:1954
    See related
    Ensembl:ENSG00000184984 MIM:118496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HM5
    Summary
    The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See CHRM5 in Genome Data Viewer
    Location:
    15q14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (33968314..34065094)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34260446..34357295)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928134 Neighboring gene ryanodine receptor 3 Neighboring gene complement C1q binding protein pseudogene 3 Neighboring gene apoptosis and caspase activation inhibitor Neighboring gene uncharacterized LOC107984748 Neighboring gene ribosomal protein L32 pseudogene 2 Neighboring gene ER membrane protein complex subunit 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC41838

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol phospholipase C activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled acetylcholine receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dopamine transport IEA
    Inferred from Electronic Annotation
    more info
     
    gastric acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    transmission of nerve impulse IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    muscarinic acetylcholine receptor M5
    Names
    acetylcholine receptor, muscarinic 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320917.2NP_001307846.1  muscarinic acetylcholine receptor M5

      Status: VALIDATED

      Source sequence(s)
      AC009268, AC069045, BX102692
      Consensus CDS
      CCDS10031.1
      UniProtKB/Swiss-Prot
      P08912
      UniProtKB/TrEMBL
      A0A024R9I2
      Related
      ENSP00000453745.1, ENST00000557872.1
      Conserved Domains (2) summary
      pfam00001
      Location:47225
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:40167
      7tm_4; Olfactory receptor
    2. NM_012125.4NP_036257.1  muscarinic acetylcholine receptor M5

      See identical proteins and their annotated locations for NP_036257.1

      Status: VALIDATED

      Source sequence(s)
      AC009268, AC069045, AK095198, BC041805
      Consensus CDS
      CCDS10031.1
      UniProtKB/Swiss-Prot
      P08912
      UniProtKB/TrEMBL
      A0A024R9I2, Q8IVW0
      Related
      ENSP00000372750.5, ENST00000383263.6
      Conserved Domains (2) summary
      pfam00001
      Location:47225
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:40167
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      33968497..34067458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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