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    DDX20 DEAD-box helicase 20 [ Homo sapiens (human) ]

    Gene ID: 11218, updated on 17-Jun-2019

    Summary

    Official Symbol
    DDX20provided by HGNC
    Official Full Name
    DEAD-box helicase 20provided by HGNC
    Primary source
    HGNC:HGNC:2743
    See related
    Ensembl:ENSG00000064703 MIM:606168
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DP103; GEMIN3
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 58.2), bone marrow (RPKM 6.4) and 17 other tissues See more
    Orthologs

    Genomic context

    See DDX20 in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (111755901..111768000)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (112298190..112310199)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene RNA, U6 small nuclear 151, pseudogene Neighboring gene uncharacterized LOC101928718 Neighboring gene INKA2 antisense RNA 1 Neighboring gene inka box actin regulator 2 Neighboring gene potassium voltage-gated channel subfamily D member 3 Neighboring gene KCND3 intronic transcript 1 Neighboring gene KCND3 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 (DDX20) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Metabolism of non-coding RNA, organism-specific biosystem (from REACTOME)
      Metabolism of non-coding RNA, organism-specific biosystemThe term non-coding is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. There is considerable evidence tha...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Survival motor neuron (SMN) complex, organism-specific biosystem (from KEGG)
      Survival motor neuron (SMN) complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • Survival motor neuron (SMN) complex, conserved biosystem (from KEGG)
      Survival motor neuron (SMN) complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
    • mRNA Processing, organism-specific biosystem (from WikiPathways)
      mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    • snRNP Assembly, organism-specific biosystem (from REACTOME)
      snRNP Assembly, organism-specific biosystemSmall nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp434H052

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    import into nucleus TAS
    Traceable Author Statement
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spliceosomal snRNP assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spliceosomal snRNP assembly TAS
    Traceable Author Statement
    more info
     
    spliceosomal tri-snRNP complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Gemini of coiled bodies IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II transcription repressor complex IEA
    Inferred from Electronic Annotation
    more info
     
    SMN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SMN complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SMN-Sm protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane HDA PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    probable ATP-dependent RNA helicase DDX20
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
    DEAD box protein 20
    DEAD box protein DP 103
    DEAD-box protein DP103
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD
    SMN-interacting protein
    component of gems 3
    gemin-3
    NP_009135.4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007204.5NP_009135.4  probable ATP-dependent RNA helicase DDX20

      See identical proteins and their annotated locations for NP_009135.4

      Status: REVIEWED

      Source sequence(s)
      AF171063, AK001506, AL049557, AY007146
      Consensus CDS
      CCDS842.1
      UniProtKB/Swiss-Prot
      Q9UHI6
      UniProtKB/TrEMBL
      Q9H4N4
      Related
      ENSP00000358716.4, ENST00000369702.5
      Conserved Domains (3) summary
      smart00487
      Location:77279
      DEXDc; DEAD-like helicases superfamily
      pfam00271
      Location:294404
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:64265
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      111755901..111768000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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