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    CIT citron rho-interacting serine/threonine kinase [ Homo sapiens (human) ]

    Gene ID: 11113, updated on 22-Apr-2017
    Official Symbol
    CITprovided by HGNC
    Official Full Name
    citron rho-interacting serine/threonine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:1985
    See related
    Ensembl:ENSG00000122966 MIM:605629; Vega:OTTHUMG00000134325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CITK; CRIK; STK21; MCPH17
    Summary
    This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
    Orthologs
    Location:
    12q24.23
    Exon count:
    50
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (119685790..119877318, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120123595..120315095, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370027 Neighboring gene transmembrane protein 233 Neighboring gene RNA, 7SK small nuclear pseudogene 197 Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 1 Neighboring gene microRNA 1178 Neighboring gene ribosomal protein L35a pseudogene 30 Neighboring gene BICD family like cargo adaptor 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Ectopic expression of citron kinase leads to the formation of cytoplasmic structures containing citron kinase and HIV-1 Gag proteins PubMed

    Go to the HIV-1, Human Interaction Database

    • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases activate CIT, organism-specific biosystem (from REACTOME)
      RHO GTPases activate CIT, organism-specific biosystemCitron kinase (CIT) or citron RHO-interacting kinase (CRIK) shares similarities with ROCK kinases. Like ROCK, it consists of a serine/threonine kinase domain, a coiled-coil region, a RHO-binding doma...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0949

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    PDZ domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rho GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    scaffold protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi organization IEA
    Inferred from Electronic Annotation
    more info
     
    cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    generation of neurons ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of actin polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi cisterna IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    citron Rho-interacting kinase
    Names
    citron (rho-interacting, serine/threonine kinase 21)
    serine/threonine kinase 21
    serine/threonine-protein kinase 21
    NP_001193928.1
    NP_009105.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029792.1 RefSeqGene

      Range
      5001..196501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206999.1NP_001193928.1  citron Rho-interacting kinase isoform 1

      See identical proteins and their annotated locations for NP_001193928.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AY257469, AY681966
      Consensus CDS
      CCDS55891.1
      UniProtKB/Swiss-Prot
      O14578
      Related
      ENSP00000376306.2, OTTHUMP00000239872, ENST00000392521.6, OTTHUMT00000401847
      Conserved Domains (6) summary
      smart00036
      Location:16351931
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:4741335
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:14051453
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:14861605
      PH; PH domain
    2. NM_007174.2NP_009105.1  citron Rho-interacting kinase isoform 2

      See identical proteins and their annotated locations for NP_009105.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AY257469, AY681966
      Consensus CDS
      CCDS9192.1
      UniProtKB/Swiss-Prot
      O14578
      Related
      ENSP00000261833.7, OTTHUMP00000166060, ENST00000261833.11, OTTHUMT00000259410
      Conserved Domains (7) summary
      smart00036
      Location:15931889
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:558844
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      COG4942
      Location:10831365
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:13631411
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:14441563
      PH; PH domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      119685790..119877318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537788.1XP_011536090.1  citron Rho-interacting kinase isoform X9

      Conserved Domains (7) summary
      smart00036
      Location:15781874
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:558844
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      COG4942
      Location:10831350
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:13481396
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:14291548
      PH; PH domain
    2. XM_011537787.1XP_011536089.1  citron Rho-interacting kinase isoform X8

      See identical proteins and their annotated locations for XP_011536089.1

      Conserved Domains (7) summary
      smart00036
      Location:15781874
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:558844
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      COG4942
      Location:10831350
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:13481396
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:14291548
      PH; PH domain
    3. XM_017018737.1XP_016874226.1  citron Rho-interacting kinase isoform X7

    4. XM_006719206.2XP_006719269.1  citron Rho-interacting kinase isoform X6

      Conserved Domains (6) summary
      smart00036
      Location:16201916
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:4741320
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:13901438
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:14711590
      PH; PH domain
    5. XM_017018736.1XP_016874225.1  citron Rho-interacting kinase isoform X5

    6. XM_011537785.1XP_011536087.1  citron Rho-interacting kinase isoform X3

      Conserved Domains (6) summary
      smart00036
      Location:16351931
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:4741320
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:13901438
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:14711590
      PH; PH domain
    7. XM_017018735.1XP_016874224.1  citron Rho-interacting kinase isoform X4

    8. XM_011537784.1XP_011536086.1  citron Rho-interacting kinase isoform X2

      Conserved Domains (6) summary
      smart00036
      Location:16501946
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:14051453
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:14861605
      PH; PH domain
      pfam09730
      Location:4831110
      BicD; Microtubule-associated protein Bicaudal-D
    9. XM_011537783.1XP_011536085.1  citron Rho-interacting kinase isoform X1

      Conserved Domains (6) summary
      smart00036
      Location:16501946
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:4741335
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:14051453
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:14861605
      PH; PH domain
    10. XM_011537790.2XP_011536092.1  citron Rho-interacting kinase isoform X10

      See identical proteins and their annotated locations for XP_011536092.1

      Conserved Domains (9) summary
      smart00036
      Location:12041500
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00233
      Location:10401159
      PH; Pleckstrin homology domain
      COG4942
      Location:679961
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:2641
      PRK03918; chromosome segregation protein; Provisional
      cd00029
      Location:9591007
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00169
      Location:10401159
      PH; PH domain
      pfam00836
      Location:231319
      Stathmin; Stathmin family
      pfam09311
      Location:462743
      Rab5-bind; Rabaptin-like protein
      cl00788
      Location:188253
      MttA_Hcf106; mttA/Hcf106 family
    11. XM_011537789.1XP_011536091.1  citron Rho-interacting kinase isoform X10

      See identical proteins and their annotated locations for XP_011536091.1

      Conserved Domains (9) summary
      smart00036
      Location:12041500
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00233
      Location:10401159
      PH; Pleckstrin homology domain
      COG4942
      Location:679961
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:2641
      PRK03918; chromosome segregation protein; Provisional
      cd00029
      Location:9591007
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00169
      Location:10401159
      PH; PH domain
      pfam00836
      Location:231319
      Stathmin; Stathmin family
      pfam09311
      Location:462743
      Rab5-bind; Rabaptin-like protein
      cl00788
      Location:188253
      MttA_Hcf106; mttA/Hcf106 family
    12. XM_011537792.2XP_011536094.1  citron Rho-interacting kinase isoform X13

      See identical proteins and their annotated locations for XP_011536094.1

      Conserved Domains (8) summary
      smart00036
      Location:11121408
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00233
      Location:9631082
      PH; Pleckstrin homology domain
      COG1340
      Location:92378
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      COG4942
      Location:617884
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:882930
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00169
      Location:9631082
      PH; PH domain
      pfam09311
      Location:400681
      Rab5-bind; Rabaptin-like protein
      cl00788
      Location:168243
      MttA_Hcf106; mttA/Hcf106 family
    13. XM_017018739.1XP_016874228.1  citron Rho-interacting kinase isoform X13

      Related
      ENSP00000376305.2, OTTHUMP00000239873, ENST00000392520.2, OTTHUMT00000401848
      Conserved Domains (8) summary
      smart00036
      Location:11121408
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00233
      Location:9631082
      PH; Pleckstrin homology domain
      COG1340
      Location:92378
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      COG4942
      Location:617884
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:882930
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00169
      Location:9631082
      PH; PH domain
      pfam09311
      Location:400681
      Rab5-bind; Rabaptin-like protein
      cl00788
      Location:168243
      MttA_Hcf106; mttA/Hcf106 family
    14. XM_011537791.2XP_011536093.1  citron Rho-interacting kinase isoform X11

      Conserved Domains (9) summary
      smart00036
      Location:11841480
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00233
      Location:10201139
      PH; Pleckstrin homology domain
      COG4942
      Location:659941
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:12578
      PRK03918; chromosome segregation protein; Provisional
      cd00029
      Location:939987
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00169
      Location:10201139
      PH; PH domain
      pfam00836
      Location:211299
      Stathmin; Stathmin family
      pfam09311
      Location:442723
      Rab5-bind; Rabaptin-like protein
      cl00788
      Location:168233
      MttA_Hcf106; mttA/Hcf106 family
    15. XM_017018738.1XP_016874227.1  citron Rho-interacting kinase isoform X12

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      120091103..120282752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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