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    HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 [ Homo sapiens (human) ]

    Gene ID: 11100, updated on 8-Dec-2022

    Summary

    Official Symbol
    HNRNPUL1provided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein U like 1provided by HGNC
    Primary source
    HGNC:HGNC:17011
    See related
    Ensembl:ENSG00000105323 MIM:605800; AllianceGenome:HGNC:17011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E1BAP5; E1B-AP5; HNRPUL1
    Summary
    This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in testis (RPKM 41.5), ovary (RPKM 40.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HNRNPUL1 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41262557..41307787)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44083416..44128645)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41768462..41813692)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily S member 1 Neighboring gene AXL receptor tyrosine kinase Neighboring gene tRNA-Lys (anticodon TTT) 10-1 Neighboring gene RNA, 7SL, cytoplasmic 34, pseudogene Neighboring gene uncharacterized LOC105372401 Neighboring gene coiled-coil domain containing 97 Neighboring gene transforming growth factor beta 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that HNRNPUL1 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with HNRNPUL1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12944

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein U-like protein 1
    Names
    E1B 55kDa associated protein 5
    E1B-55 kDa-associated protein 5
    adenovirus early region 1B-associated protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301016.3NP_001287945.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform e

      See identical proteins and their annotated locations for NP_001287945.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform e, which has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC011462, AC011510
      Consensus CDS
      CCDS82351.1
      UniProtKB/TrEMBL
      B7Z4B8
      Related
      ENSP00000263367.3, ENST00000263367.7
      Conserved Domains (3) summary
      pfam13671
      Location:334479
      AAA_33; AAA domain
      cd12884
      Location:122299
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:334472
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    2. NM_001321208.2NP_001308137.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC011462, AC011510
      Consensus CDS
      CCDS12577.1
      UniProtKB/Swiss-Prot
      Q9BUJ2
      UniProtKB/TrEMBL
      A0A024R0J9
      Conserved Domains (3) summary
      pfam13671
      Location:323468
      AAA_33; AAA domain
      cd12884
      Location:111288
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:323461
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    3. NM_001321211.2NP_001308140.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC011462, AC011510
      Consensus CDS
      CCDS12577.1
      UniProtKB/Swiss-Prot
      Q9BUJ2
      UniProtKB/TrEMBL
      A0A024R0J9, A8K3W4
      Related
      ENSP00000472629.1, ENST00000593587.5
      Conserved Domains (3) summary
      pfam13671
      Location:323468
      AAA_33; AAA domain
      cd12884
      Location:111288
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:323461
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    4. NM_007040.6NP_008971.2  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_008971.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC011462, AC011510
      Consensus CDS
      CCDS12576.1
      UniProtKB/Swiss-Prot
      Q9BUJ2, Q9UG75
      Related
      ENSP00000375863.2, ENST00000392006.8
      Conserved Domains (4) summary
      smart00513
      Location:337
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam13671
      Location:423568
      AAA_33; AAA domain
      cd12884
      Location:211388
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:423561
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    5. NM_144732.5NP_653333.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform d

      See identical proteins and their annotated locations for NP_653333.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region compared to variant 1, resulting in an isoform (d) that maintains the reading frame but is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC011462, AC011510
      Consensus CDS
      CCDS12577.1
      UniProtKB/Swiss-Prot
      Q9BUJ2
      UniProtKB/TrEMBL
      A0A024R0J9
      Related
      ENSP00000473132.1, ENST00000595018.5
      Conserved Domains (3) summary
      pfam13671
      Location:323468
      AAA_33; AAA domain
      cd12884
      Location:111288
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:323461
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      41262557..41307787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258464.5XP_005258521.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_005258521.1

      UniProtKB/TrEMBL
      A0A0A0MRA5
      Related
      ENSP00000340857.3, ENST00000352456.7
      Conserved Domains (3) summary
      pfam13671
      Location:323468
      AAA_33; AAA domain
      cd12884
      Location:111288
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:323461
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    2. XM_047438115.1XP_047294071.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X7

      Related
      ENSP00000473178.1, ENST00000599614.5
    3. XM_011526395.4XP_011524697.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_011524697.1

      UniProtKB/TrEMBL
      A0A0A0MRA5
      Conserved Domains (3) summary
      pfam13671
      Location:323468
      AAA_33; AAA domain
      cd12884
      Location:111288
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:323461
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    4. XM_011526393.4XP_011524695.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_011524695.1

      UniProtKB/TrEMBL
      A0A0A0MRA5
      Conserved Domains (3) summary
      pfam13671
      Location:323468
      AAA_33; AAA domain
      cd12884
      Location:111288
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:323461
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    5. XM_005258459.5XP_005258516.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1

      Related
      ENSP00000367460.3, ENST00000378215.8
      Conserved Domains (4) summary
      smart00513
      Location:337
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam13671
      Location:423568
      AAA_33; AAA domain
      cd12884
      Location:211388
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:423561
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    6. XM_011526392.4XP_011524694.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X2

      Conserved Domains (4) summary
      smart00513
      Location:337
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam13671
      Location:423568
      AAA_33; AAA domain
      cd12884
      Location:211388
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:423561
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    7. XM_005258463.5XP_005258520.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_005258520.1

      UniProtKB/TrEMBL
      A0A0A0MRA5
      Conserved Domains (3) summary
      pfam13671
      Location:323468
      AAA_33; AAA domain
      cd12884
      Location:111288
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:323461
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    8. XM_011526394.4XP_011524696.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_011524696.1

      UniProtKB/TrEMBL
      A0A0A0MRA5
      Conserved Domains (3) summary
      pfam13671
      Location:323468
      AAA_33; AAA domain
      cd12884
      Location:111288
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:323461
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    9. XM_005258461.6XP_005258518.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X3

      Conserved Domains (3) summary
      pfam13671
      Location:334479
      AAA_33; AAA domain
      cd12884
      Location:122299
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:334472
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    10. XM_047438114.1XP_047294070.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X6

    11. XM_005258465.6XP_005258522.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_005258522.1

      UniProtKB/TrEMBL
      A0A0A0MRA5
      Conserved Domains (3) summary
      pfam13671
      Location:323468
      AAA_33; AAA domain
      cd12884
      Location:111288
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:323461
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    12. XM_047438113.1XP_047294069.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A024R0J9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      44083416..44128645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144733.1: Suppressed sequence

      Description
      NM_144733.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_144734.1: Suppressed sequence

      Description
      NM_144734.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.