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    RAB31 RAB31, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 11031, updated on 17-Jun-2024

    Summary

    Official Symbol
    RAB31provided by HGNC
    Official Full Name
    RAB31, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9771
    See related
    Ensembl:ENSG00000168461 MIM:605694; AllianceGenome:HGNC:9771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Rab22B
    Summary
    Enables GDP binding activity and GTP binding activity. Involved in several processes, including Golgi to plasma membrane protein transport; cellular response to insulin stimulus; and receptor internalization. Located in early endosome; phagocytic vesicle; and trans-Golgi network membrane. Biomarker of severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 65.3), adrenal (RPKM 60.7) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RAB31 in Genome Data Viewer
    Location:
    18p11.22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (9708301..9862551)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (9871688..10026019)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (9708298..9862548)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904244 Neighboring gene keratin 18 pseudogene 8 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:9697747-9697949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9287 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9288 Neighboring gene uncharacterized LOC105371981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:9734599-9735098 Neighboring gene Sharpr-MPRA regulatory region 12333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13078 Neighboring gene zinc finger protein 415 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:9808911-9809561 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:9831825-9832370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:9832371-9832916 Neighboring gene RNA, 7SL, cytoplasmic 862, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 449 Neighboring gene CRISPRi-validated cis-regulatory element chr18.299 Neighboring gene CRISPRi-validated cis-regulatory element chr18.300 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class P pseudogene 4 Neighboring gene thioredoxin domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulated exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in early phagosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in phagocytic cup ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ras-related protein Rab-31
    Names
    ras-related protein Rab-22B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006868.4NP_006859.2  ras-related protein Rab-31

      See identical proteins and their annotated locations for NP_006859.2

      Status: VALIDATED

      Source sequence(s)
      AF183421, AF234995, BU608212, CB243279, CK005533, CN429637, DA068356
      Consensus CDS
      CCDS45826.1
      UniProtKB/Swiss-Prot
      B2RBT7, Q13636, Q15770, Q9HC00
      UniProtKB/TrEMBL
      Q53EY4
      Related
      ENSP00000461945.2, ENST00000578921.6
      Conserved Domains (1) summary
      cd01860
      Location:6168
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      9708301..9862551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      9871688..10026019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)