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    RBPMS RNA binding protein, mRNA processing factor [ Homo sapiens (human) ]

    Gene ID: 11030, updated on 7-Apr-2024

    Summary

    Official Symbol
    RBPMSprovided by HGNC
    Official Full Name
    RNA binding protein, mRNA processing factorprovided by HGNC
    Primary source
    HGNC:HGNC:19097
    See related
    Ensembl:ENSG00000157110 MIM:601558; AllianceGenome:HGNC:19097
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HERMES
    Summary
    This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
    Expression
    Ubiquitous expression in prostate (RPKM 14.5), ovary (RPKM 13.7) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RBPMS in Genome Data Viewer
    Location:
    8p12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (30384541..30572256)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (30663428..30851701)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30242057..30429773)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 84 Neighboring gene tubulin beta pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:30241844-30242514 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30242515-30243186 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:30251401-30252099 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30252799-30253496 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30254895-30255593 Neighboring gene RBPMS antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 541 Neighboring gene heart enhancer 24 Neighboring gene uncharacterized LOC112268025 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:30284105-30284606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:30284607-30285106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30295211-30295746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:30303831-30304359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:30304360-30304887 Neighboring gene Sharpr-MPRA regulatory region 3907 Neighboring gene NANOG hESC enhancer GRCh37_chr8:30310384-30310885 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30318783-30319578 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:30333285-30333476 Neighboring gene uncharacterized LOC124901929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30396143-30396854 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30396862-30397470 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30397471-30398079 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30398080-30398688 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:30399297-30399906 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:30398689-30399296 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30400515-30401122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30401123-30401730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27212 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30406725-30407384 Neighboring gene Sharpr-MPRA regulatory region 2547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19077 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:30415639-30416140 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:30416141-30416640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30422314-30422922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19079 Neighboring gene general transcription factor IIE subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27213 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:30514282-30514953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19080 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30515625-30516296 Neighboring gene RNA, U5A small nuclear 3, pseudogene Neighboring gene small integral membrane protein 18 Neighboring gene NANOG hESC enhancer GRCh37_chr8:30560335-30560881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19082 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30584261-30584948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19083 Neighboring gene glutathione-disulfide reductase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32971

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA CDS binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pre-mRNA intronic binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    RNA-binding protein with multiple splicing
    Names
    RNA binding protein with multiple splicing
    heart and RRM expressed sequence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029534.2 RefSeqGene

      Range
      5002..192717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001008710.3NP_001008710.1  RNA-binding protein with multiple splicing isoform A

      See identical proteins and their annotated locations for NP_001008710.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform A. Variants 1 and 4 encode the same isoform.
      Source sequence(s)
      BC003608, BX097929, CN360712, CX165198, CX781149, D84107
      Consensus CDS
      CCDS6077.1
      UniProtKB/Swiss-Prot
      D3DSU9, Q92516, Q92517, Q92518, Q93062, Q96J26
      UniProtKB/TrEMBL
      Q569H2
      Related
      ENSP00000380486.4, ENST00000397323.9
      Conserved Domains (2) summary
      TIGR01628
      Location:64165
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12682
      Location:2398
      RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
    2. NM_001008711.3NP_001008711.1  RNA-binding protein with multiple splicing isoform B

      See identical proteins and their annotated locations for NP_001008711.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (B) has a longer and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      BC003608, BX097929, CN360712, CX165198, CX781149, D84108
      Consensus CDS
      CCDS34875.1
      UniProtKB/TrEMBL
      Q569H2
      Related
      ENSP00000287771.5, ENST00000287771.9
      Conserved Domains (2) summary
      cd12682
      Location:2398
      RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
      cl25887
      Location:26200
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    3. NM_001008712.3NP_001008712.1  RNA-binding protein with multiple splicing isoform C

      See identical proteins and their annotated locations for NP_001008712.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (C) has a longer and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AI025136, BC003608, CX165198
      Consensus CDS
      CCDS34876.1
      UniProtKB/TrEMBL
      Q569H2
      Related
      ENSP00000340176.4, ENST00000339877.8
      Conserved Domains (2) summary
      TIGR01628
      Location:64187
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12682
      Location:2398
      RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
    4. NM_006867.4NP_006858.1  RNA-binding protein with multiple splicing isoform A

      See identical proteins and their annotated locations for NP_006858.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) includes an alternate exon in the 3' UTR compared to variant 1. Variants 1 and 4 encode the same isoform (A).
      Source sequence(s)
      BC003608, BX097929, CA425568, CN360712, CX165198, CX781149, D84107
      Consensus CDS
      CCDS6077.1
      UniProtKB/Swiss-Prot
      D3DSU9, Q92516, Q92517, Q92518, Q93062, Q96J26
      UniProtKB/TrEMBL
      Q569H2
      Related
      ENSP00000318102.4, ENST00000320203.8
      Conserved Domains (2) summary
      TIGR01628
      Location:64165
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12682
      Location:2398
      RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      30384541..30572256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012981.3XP_016868470.1  RNA-binding protein with multiple splicing isoform X3

    2. XM_017012987.3XP_016868476.1  RNA-binding protein with multiple splicing isoform X8

    3. XM_047421276.1XP_047277232.1  RNA-binding protein with multiple splicing isoform X2

    4. XM_047421278.1XP_047277234.1  RNA-binding protein with multiple splicing isoform X12

    5. XM_047421281.1XP_047277237.1  RNA-binding protein with multiple splicing isoform X18

    6. XM_047421277.1XP_047277233.1  RNA-binding protein with multiple splicing isoform X10

    7. XM_017012982.2XP_016868471.1  RNA-binding protein with multiple splicing isoform X4

      Conserved Domains (1) summary
      cd12682
      Location:2398
      RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
    8. XM_017012980.3XP_016868469.1  RNA-binding protein with multiple splicing isoform X1

    9. XM_017012990.3XP_016868479.1  RNA-binding protein with multiple splicing isoform X13

    10. XM_024447054.2XP_024302822.1  RNA-binding protein with multiple splicing isoform X6

      Conserved Domains (2) summary
      cl17169
      Location:1440
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl27087
      Location:40131
      SPOR; Sporulation related domain
    11. XM_017012989.3XP_016868478.1  RNA-binding protein with multiple splicing isoform X11

      UniProtKB/TrEMBL
      Q569H2
      Conserved Domains (1) summary
      cl17169
      Location:2398
      RRM_SF; RNA recognition motif (RRM) superfamily
    12. XM_017012988.3XP_016868477.1  RNA-binding protein with multiple splicing isoform X9

      UniProtKB/TrEMBL
      Q569H2
      Conserved Domains (2) summary
      TIGR01628
      Location:64165
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cl17169
      Location:2398
      RRM_SF; RNA recognition motif (RRM) superfamily
    13. XM_017012992.3XP_016868481.1  RNA-binding protein with multiple splicing isoform X17

      Conserved Domains (1) summary
      cd12682
      Location:2398
      RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
    14. XM_047421279.1XP_047277235.1  RNA-binding protein with multiple splicing isoform X14

    15. XM_017012984.2XP_016868473.1  RNA-binding protein with multiple splicing isoform X5

      UniProtKB/TrEMBL
      B4E3T4
      Related
      ENSP00000428675.1, ENST00000517860.5
      Conserved Domains (1) summary
      cd12682
      Location:2398
      RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
    16. XM_017012985.3XP_016868474.1  RNA-binding protein with multiple splicing isoform X7

    17. XM_047421280.1XP_047277236.1  RNA-binding protein with multiple splicing isoform X16

    18. XM_024447055.2XP_024302823.1  RNA-binding protein with multiple splicing isoform X15

      Conserved Domains (1) summary
      cl17169
      Location:538
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. XR_007060693.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      30663428..30851701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359616.1XP_054215591.1  RNA-binding protein with multiple splicing isoform X3

    2. XM_054359621.1XP_054215596.1  RNA-binding protein with multiple splicing isoform X8

    3. XM_054359615.1XP_054215590.1  RNA-binding protein with multiple splicing isoform X2

    4. XM_054359625.1XP_054215600.1  RNA-binding protein with multiple splicing isoform X12

    5. XM_054359623.1XP_054215598.1  RNA-binding protein with multiple splicing isoform X10

    6. XM_054359617.1XP_054215592.1  RNA-binding protein with multiple splicing isoform X4

    7. XM_054359614.1XP_054215589.1  RNA-binding protein with multiple splicing isoform X1

    8. XM_054359626.1XP_054215601.1  RNA-binding protein with multiple splicing isoform X13

    9. XM_054359624.1XP_054215599.1  RNA-binding protein with multiple splicing isoform X11

    10. XM_054359622.1XP_054215597.1  RNA-binding protein with multiple splicing isoform X9

    11. XM_054359630.1XP_054215605.1  RNA-binding protein with multiple splicing isoform X17

    12. XM_054359619.1XP_054215594.1  RNA-binding protein with multiple splicing isoform X5

      UniProtKB/TrEMBL
      B4E3T4
    13. XM_054359618.1XP_054215593.1  RNA-binding protein with multiple splicing isoform X19

    14. XM_054359627.1XP_054215602.1  RNA-binding protein with multiple splicing isoform X20

    15. XM_054359628.1XP_054215603.1  RNA-binding protein with multiple splicing isoform X15

    16. XM_054359620.1XP_054215595.1  RNA-binding protein with multiple splicing isoform X7

    17. XM_054359629.1XP_054215604.1  RNA-binding protein with multiple splicing isoform X16

    RNA

    1. XR_008487799.1 RNA Sequence