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    SNRNP27 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 [ Homo sapiens (human) ]

    Gene ID: 11017, updated on 17-Jun-2019

    Summary

    Official Symbol
    SNRNP27provided by HGNC
    Official Full Name
    small nuclear ribonucleoprotein U4/U6.U5 subunit 27provided by HGNC
    Primary source
    HGNC:HGNC:30240
    See related
    Ensembl:ENSG00000124380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    27K; RY1
    Summary
    This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the long arm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in brain (RPKM 19.6), adrenal (RPKM 18.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See SNRNP27 in Genome Data Viewer
    Location:
    2p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (69893943..69905236)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (70121075..70132368)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene annexin A4 Neighboring gene natural cytotoxicity triggering receptor 3 ligand 1-like Neighboring gene germ cell-less 1, spermatogenesis associated Neighboring gene ribosomal protein L23a pseudogene 92 Neighboring gene MAX dimerization protein 1 Neighboring gene PCBP1 antisense RNA 1 Neighboring gene aspartic peptidase retroviral like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, U4/U6.U5 tri-snRNP, organism-specific biosystem (from KEGG)
      Spliceosome, U4/U6.U5 tri-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Spliceosome, U4/U6.U5 tri-snRNP, conserved biosystem (from KEGG)
      Spliceosome, U4/U6.U5 tri-snRNP, conserved biosystemStructural complex; Genetic information processing; Spliceosome
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nucleic acid binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
    Names
    U4/U6.U5 tri-snRNP-associated 27 kDa protein
    U4/U6.U5 tri-snRNP-associated protein 3
    U4/U6.U5-27K
    putative nucleic acid binding protein RY-1
    small nuclear ribonucleoprotein 27kDa (U4/U6.U5)
    small nuclear ribonucleoprotein, U4/U6.U5 27kDa subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006857.3NP_006848.1  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

      See identical proteins and their annotated locations for NP_006848.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes a functional protein.
      Source sequence(s)
      AC019206, AW452063, BC017890, X76302
      Consensus CDS
      CCDS33219.1
      UniProtKB/Swiss-Prot
      Q8WVK2
      UniProtKB/TrEMBL
      A8K513
      Related
      ENSP00000244227.3, ENST00000244227.8
      Conserved Domains (1) summary
      pfam08648
      Location:30151
      DUF1777; Protein of unknown function (DUF1777)

    RNA

    1. NR_037862.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is represented as non-coding because it uses an alternate splice site in the 3' UTR, compared to variant 1, which renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC019206, AW452063, BU171817, X76302
      Related
      ENST00000409116.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      69893943..69905236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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