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    YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [ Homo sapiens (human) ]

    Gene ID: 10971, updated on 5-Feb-2023


    Official Symbol
    YWHAQprovided by HGNC
    Official Full Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaprovided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000134308 MIM:609009; AllianceGenome:HGNC:12854
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    1C5; HS1; 14-3-3
    This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
    Ubiquitous expression in brain (RPKM 160.3), endometrium (RPKM 117.5) and 25 other tissues See more
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    Genomic context

    See YWHAQ in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (9583967..9630997, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (9609000..9656011, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (9724096..9771126, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1969 Neighboring gene uncharacterized LOC101929643 Neighboring gene uncharacterized LOC105373418 Neighboring gene uncharacterized LOC105373419

    Genomic regions, transcripts, and products


    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?


    EBI GWAS Catalog

    Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of cells with dsRNA against 14-3-3tau enhances gp120-mediated dephosphorylation of Bad and its association with Bcl-XL in mitochondria, and accelerates gp120-induced apoptosis PubMed
    env HIV-1 gp120 increases the expression of 14-3-3tau in cells. The binding of gp120 to CXCR4 induces cell apoptosis through decreased binding of 14-3-3tau to the pro-apoptotic molecule, Bad PubMed
    Vpr vpr Vpr-induced cell cycle G2/M arrest reveals a dramatic increase in the amount of Cdk1, Cdc25C, and CyclinB1 bound to 14-3-3 theta PubMed
    vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
    vpr Yeast two-hybrid assays show that the C-terminal half (residues 141-244) of 14-3-3 tau binds to HIV-1 Vpr; Vpr supports triple complex formation with 14-3-3 tau and Cdc25C PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information



    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IEA
    Inferred from Electronic Annotation
    more info
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    located_in cytosol TAS
    Traceable Author Statement
    more info
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in membrane HDA PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info

    General protein information

    Preferred Names
    14-3-3 protein theta
    14-3-3 protein T-cell
    14-3-3 protein tau
    14-3-3 theta
    protein, theta
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006826.4NP_006817.1  14-3-3 protein theta

      See identical proteins and their annotated locations for NP_006817.1

      Status: REVIEWED

      Source sequence(s)
      AA729400, BC050601, BC093019
      Consensus CDS
      P27348, Q9UP48
      ENSP00000238081.3, ENST00000238081.8
      Conserved Domains (1) summary
      14-3-3_theta; 14-3-3 theta/tau (theta in mice, tau in human), an isoform of 14-3-3 protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly


    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      9583967..9630997 complement
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0


    1. NC_060926.1 Alternate T2T-CHM13v2.0

      9609000..9656011 complement
      GenBank, FASTA, Sequence Viewer (Graphics)