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    RALBP1 ralA binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 10928, updated on 17-Jun-2024

    Summary

    Official Symbol
    RALBP1provided by HGNC
    Official Full Name
    ralA binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:9841
    See related
    Ensembl:ENSG00000017797 MIM:605801; AllianceGenome:HGNC:9841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RIP1; RLIP1; RLIP76
    Summary
    RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]
    Expression
    Ubiquitous expression in kidney (RPKM 28.4), skin (RPKM 27.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RALBP1 in Genome Data Viewer
    Location:
    18p11.22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (9475009..9538114)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (9636797..9701515)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (9475511..9538112)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:9335059-9335559 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50729 Neighboring gene twisted gastrulation BMP signaling modulator 1 Neighboring gene uncharacterized LOC105371980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:9416837-9417784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13074 Neighboring gene NANOG hESC enhancer GRCh37_chr18:9453672-9454285 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:9475475-9476343 Neighboring gene iroquois homeobox 4 pseudogene 1 Neighboring gene RNA, U2 small nuclear 27, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr18:9570108-9570290 Neighboring gene protein phosphatase 4 regulatory subunit 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:9574228-9574738 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:9574739-9575249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9284 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9286 Neighboring gene PPP4R1 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 903, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ralA binding protein 1 (RALBP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ABC-type glutathione S-conjugate transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ABC-type xenobiotic transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATPase-coupled transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables xenobiotic transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ralA-binding protein 1
    Names
    76 kDa Ral-interacting protein
    DNP-SG ATPase
    dinitrophenyl S-glutathione ATPase
    ral-interacting protein 1
    NP_006779.1
    XP_047293234.1
    XP_047293235.1
    XP_047293236.1
    XP_047293237.1
    XP_047293238.1
    XP_047293239.1
    XP_047293240.1
    XP_054174134.1
    XP_054174135.1
    XP_054174136.1
    XP_054174137.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006788.4NP_006779.1  ralA-binding protein 1

      See identical proteins and their annotated locations for NP_006779.1

      Status: VALIDATED

      Source sequence(s)
      AP005432, BC013126, BF794440, BQ224100, BQ674032, BX352266, L42542
      Consensus CDS
      CCDS11845.1
      UniProtKB/Swiss-Prot
      D3DUI0, Q15311
      UniProtKB/TrEMBL
      A0A2X0U2N0
      Related
      ENSP00000372924.3, ENST00000383432.8
      Conserved Domains (2) summary
      cd04381
      Location:190371
      RhoGap_RalBP1; RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 ...
      cl25732
      Location:400627
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      9475009..9538114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437278.1XP_047293234.1  ralA-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DUI0, Q15311
      UniProtKB/TrEMBL
      A0A2X0U2N0
      Related
      ENSP00000019317.4, ENST00000019317.8
    2. XM_047437282.1XP_047293238.1  ralA-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DUI0, Q15311
      UniProtKB/TrEMBL
      A0A2X0U2N0
    3. XM_047437281.1XP_047293237.1  ralA-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DUI0, Q15311
      UniProtKB/TrEMBL
      A0A2X0U2N0
    4. XM_047437279.1XP_047293235.1  ralA-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DUI0, Q15311
      UniProtKB/TrEMBL
      A0A2X0U2N0
    5. XM_047437284.1XP_047293240.1  ralA-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DUI0, Q15311
      UniProtKB/TrEMBL
      A0A2X0U2N0
    6. XM_047437280.1XP_047293236.1  ralA-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DUI0, Q15311
      UniProtKB/TrEMBL
      A0A2X0U2N0
    7. XM_047437283.1XP_047293239.1  ralA-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DUI0, Q15311
      UniProtKB/TrEMBL
      A0A2X0U2N0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      9636797..9701515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318159.1XP_054174134.1  ralA-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DUI0, Q15311
      UniProtKB/TrEMBL
      A0A2X0U2N0
    2. XM_054318162.1XP_054174137.1  ralA-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DUI0, Q15311
      UniProtKB/TrEMBL
      A0A2X0U2N0
    3. XM_054318161.1XP_054174136.1  ralA-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DUI0, Q15311
      UniProtKB/TrEMBL
      A0A2X0U2N0
    4. XM_054318160.1XP_054174135.1  ralA-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DUI0, Q15311
      UniProtKB/TrEMBL
      A0A2X0U2N0