Format

Send to:

Choose Destination
    • Showing Current items.

    CEACAM4 carcinoembryonic antigen related cell adhesion molecule 4 [ Homo sapiens (human) ]

    Gene ID: 1089, updated on 19-Jun-2019

    Summary

    Official Symbol
    CEACAM4provided by HGNC
    Official Full Name
    carcinoembryonic antigen related cell adhesion molecule 4provided by HGNC
    Primary source
    HGNC:HGNC:1816
    See related
    Ensembl:ENSG00000105352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCA; CGM7; CGM7_HUMAN
    Expression
    Biased expression in bone marrow (RPKM 8.4), spleen (RPKM 4.0) and 4 other tissues See more
    Orthologs

    Genomic context

    See CEACAM4 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41616986..41627087, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42125344..42133442, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372404 Neighboring gene carcinoembryonic antigen related cell adhesion molecule pseudogene 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 3 Neighboring gene uncharacterized LOC105372405

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 4
    Names
    Nonspecific cross-reacting antigen (NCA)
    carcinoembryonic antigen CGM7
    carcinoembryonic antigen gene family member 7
    carcinoembryonic antigen-related cell adhesion molecule 4-sv1
    carcinoembryonic antigen-related cell adhesion molecule 4-sv2
    non-specific cross-reacting antigen W236
    nonspecific cross-reacting antigen W236

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362492.1NP_001349421.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC243960
      Conserved Domains (1) summary
      cd05774
      Location:37140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    2. NM_001362493.1NP_001349422.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC243960
    3. NM_001362495.1NP_001349424.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC243960
      Conserved Domains (1) summary
      cd05774
      Location:37140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    4. NM_001817.3NP_001808.2  carcinoembryonic antigen-related cell adhesion molecule 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001808.2

      Status: VALIDATED

      Source sequence(s)
      AC005955, AC243960, BF819374, BX644557, BX644579, D90276
      Consensus CDS
      CCDS33033.1
      UniProtKB/Swiss-Prot
      O75871
      Related
      ENSP00000221954.2, ENST00000221954.6
      Conserved Domains (2) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:44140
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      41616986..41627087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026200.1XP_016881689.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X2

    2. XM_017026208.2XP_016881697.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X13

    3. XM_017026203.2XP_016881692.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X6

    4. XM_017026212.1XP_016881701.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X19

    5. XM_011526350.2XP_011524652.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X18

      See identical proteins and their annotated locations for XP_011524652.1

      Conserved Domains (2) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:44140
      IG_like; Immunoglobulin like
    6. XM_017026206.1XP_016881695.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X10

    7. XM_011526345.3XP_011524647.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X7

      See identical proteins and their annotated locations for XP_011524647.1

      Conserved Domains (2) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:44140
      IG_like; Immunoglobulin like
    8. XM_017026202.2XP_016881691.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X5

    9. XM_017026201.2XP_016881690.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X3

    10. XM_011526352.1XP_011524654.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X21

      See identical proteins and their annotated locations for XP_011524654.1

      Related
      ENSP00000473018.1, ENST00000600925.1
      Conserved Domains (2) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:44140
      IG_like; Immunoglobulin like
    11. XM_017026209.1XP_016881698.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X14

    12. XM_017026213.1XP_016881702.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X23

    13. XM_011526354.1XP_011524656.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X22

      See identical proteins and their annotated locations for XP_011524656.1

      Conserved Domains (2) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:44140
      IG_like; Immunoglobulin like
    14. XM_011526343.1XP_011524645.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X4

      See identical proteins and their annotated locations for XP_011524645.1

      Conserved Domains (3) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:44140
      IG_like; Immunoglobulin like
      pfam07332
      Location:146197
      Phage_holin_3_6; Putative Actinobacterial Holin-X, holin superfamily III
    15. XM_017026211.1XP_016881700.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X17

    16. XM_017026199.1XP_016881688.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X1

    17. XM_011526349.3XP_011524651.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X16

      See identical proteins and their annotated locations for XP_011524651.1

      Conserved Domains (2) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:44140
      IG_like; Immunoglobulin like
    18. XM_017026204.2XP_016881693.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X8

    19. XM_017026210.1XP_016881699.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X15

    20. XM_017026207.2XP_016881696.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X11

    21. XM_017026205.1XP_016881694.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X9

    RNA

    1. XR_001753592.1 RNA Sequence

    2. XR_935719.1 RNA Sequence

    3. XR_001753593.1 RNA Sequence

    4. XR_001753594.1 RNA Sequence

    Reference GRCh38.p13 ALT_REF_LOCI_1

    Genomic

    1. NT_187620.1 Reference GRCh38.p13 ALT_REF_LOCI_1

      Range
      54927..63030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center