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    CD3EAP CD3e molecule associated protein [ Homo sapiens (human) ]

    Gene ID: 10849, updated on 17-Jun-2019

    Summary

    Official Symbol
    CD3EAPprovided by HGNC
    Official Full Name
    CD3e molecule associated proteinprovided by HGNC
    Primary source
    HGNC:HGNC:24219
    See related
    Ensembl:ENSG00000117877 MIM:107325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASE1; CAST; ASE-1; PAF49
    Expression
    Ubiquitous expression in skin (RPKM 8.1), ovary (RPKM 5.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See CD3EAP in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45406644..45410766)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45909467..45914024)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kinesin light chain 3 Neighboring gene ERCC excision repair 2, TFIIH core complex helicase subunit Neighboring gene protein phosphatase 1 regulatory subunit 13 like Neighboring gene ERCC excision repair 1, endonuclease non-catalytic subunit Neighboring gene Sharpr-MPRA regulatory region 13779 Neighboring gene microRNA 6088

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118851

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding HDA PubMed 
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase I transcription factor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    nucleolus TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerase I subunit RPA34
    Names
    CD3e antigen, epsilon polypeptide associated protein
    CD3e molecule, epsilon associated protein
    RNA polymerase I-associated factor PAF49
    antisense to ERCC-1 protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297590.2NP_001284519.1  DNA-directed RNA polymerase I subunit RPA34 isoform 1

      See identical proteins and their annotated locations for NP_001284519.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF017633, BU166593, U86751
      Consensus CDS
      CCDS74397.1
      UniProtKB/Swiss-Prot
      O15446
      Related
      ENSP00000465099.1, ENST00000589804.1
      Conserved Domains (1) summary
      pfam08208
      Location:40180
      RNA_polI_A34; DNA-directed RNA polymerase I subunit RPA34.5
    2. NM_012099.2NP_036231.1  DNA-directed RNA polymerase I subunit RPA34 isoform 2

      See identical proteins and their annotated locations for NP_036231.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      U86751
      Consensus CDS
      CCDS12661.1
      UniProtKB/Swiss-Prot
      O15446
      Related
      ENSP00000310966.3, ENST00000309424.7
      Conserved Domains (1) summary
      pfam08208
      Location:38178
      RNA_polI_A34; DNA-directed RNA polymerase I subunit RPA34.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      45406644..45410766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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