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    RPP40 ribonuclease P/MRP subunit p40 [ Homo sapiens (human) ]

    Gene ID: 10799, updated on 17-Jun-2019

    Summary

    Official Symbol
    RPP40provided by HGNC
    Official Full Name
    ribonuclease P/MRP subunit p40provided by HGNC
    Primary source
    HGNC:HGNC:20992
    See related
    Ensembl:ENSG00000124787 MIM:606117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNASEP1; bA428J1.3
    Expression
    Ubiquitous expression in adrenal (RPKM 3.2), testis (RPKM 2.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See RPP40 in Genome Data Viewer
    Location:
    6p25.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (4992405..5004063, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (4995280..5004292, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene chromodomain Y like Neighboring gene uncharacterized LOC105374897 Neighboring gene ribosomal protein S18 pseudogene 8 Neighboring gene LYRM4 antisense RNA 1 Neighboring gene LYR motif containing 4 Neighboring gene transcription factor B2, mitochondrial pseudogene Neighboring gene protein phosphatase 1 regulatory subunit 3G

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ribonuclease P/MRP 40kDa subunit (RPP40) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystem (from REACTOME)
      Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • rRNA processing, organism-specific biosystem (from REACTOME)
      rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
    • rRNA processing in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
      rRNA processing in the nucleus and cytosol, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
    • tRNA processing, organism-specific biosystem (from REACTOME)
      tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
    • tRNA processing in the nucleus, organism-specific biosystem (from REACTOME)
      tRNA processing in the nucleus, organism-specific biosystemGenes encoding transfer RNAs are transcribed in the nucleus by RNA polymerase III. (Distinct processes of transcription and processing also occur in mitochondria.) The initial transcripts, pre-tRNAs,...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ribonuclease P RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ribonuclease P activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA phosphodiester bond hydrolysis, endonucleolytic IEA
    Inferred from Electronic Annotation
    more info
     
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA 5'-leader removal IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tRNA 5'-leader removal TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    multimeric ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolar ribonuclease P complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    ribonuclease P protein subunit p40
    Names
    RNase P subunit 1
    RNaseP protein p40
    ribonuclease P (40 kD)
    ribonuclease P, 40kD subunit
    ribonuclease P/MRP 40kDa subunit
    ribonuclease P1
    NP_001273061.1
    NP_001273062.1
    NP_006629.2
    XP_011512555.1
    XP_024302077.1
    XP_024302078.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286132.2NP_001273061.1  ribonuclease P protein subunit p40 isoform b

      See identical proteins and their annotated locations for NP_001273061.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AL359643, BC017871, BM015573, BU607286, BX951376
      Consensus CDS
      CCDS69040.1
      UniProtKB/Swiss-Prot
      O75818
      Related
      ENSP00000317998.5, ENST00000319533.9
      Conserved Domains (1) summary
      pfam08584
      Location:75320
      Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit
    2. NM_001286133.1NP_001273062.1  ribonuclease P protein subunit p40 isoform c

      See identical proteins and their annotated locations for NP_001273062.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      BC017871, BM827175, BU607286, BX951376
      Consensus CDS
      CCDS75391.1
      UniProtKB/Swiss-Prot
      O75818
      UniProtKB/TrEMBL
      A0A087X1N3
      Related
      ENSP00000484334.1, ENST00000618533.4
      Conserved Domains (1) summary
      pfam08584
      Location:75301
      Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit
    3. NM_006638.4NP_006629.2  ribonuclease P protein subunit p40 isoform a

      See identical proteins and their annotated locations for NP_006629.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL359643, BC017871, BQ220155, BU607286, BX951376
      Consensus CDS
      CCDS34333.1
      UniProtKB/Swiss-Prot
      O75818
      Related
      ENSP00000369391.2, ENST00000380051.6
      Conserved Domains (1) summary
      pfam08584
      Location:75343
      Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      4992405..5004063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446309.1XP_024302077.1  ribonuclease P protein subunit p40 isoform X2

      Conserved Domains (1) summary
      pfam08584
      Location:75255
      Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit
    2. XM_011514253.2XP_011512555.1  ribonuclease P protein subunit p40 isoform X1

      Conserved Domains (1) summary
      pfam08584
      Location:75297
      Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit
    3. XM_024446310.1XP_024302078.1  ribonuclease P protein subunit p40 isoform X3

      Conserved Domains (1) summary
      pfam08584
      Location:1202
      Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit

    RNA

    1. XR_926031.2 RNA Sequence

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