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    ZMYND11 zinc finger MYND-type containing 11 [ Homo sapiens (human) ]

    Gene ID: 10771, updated on 19-Jun-2019

    Summary

    Official Symbol
    ZMYND11provided by HGNC
    Official Full Name
    zinc finger MYND-type containing 11provided by HGNC
    Primary source
    HGNC:HGNC:16966
    See related
    Ensembl:ENSG00000015171 MIM:608668
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BS69; BRAM1; MRD30
    Summary
    The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 38.3), brain (RPKM 25.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZMYND11 in Genome Data Viewer
    Location:
    10p15.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (130088..254637)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (180405..300577)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tubulin beta 8 class VIII Neighboring gene interleukin 9 receptor pseudogene 2 Neighboring gene RNA, 5S ribosomal pseudogene 297 Neighboring gene DEAD-box helicase 20 pseudogene 1 Neighboring gene uncharacterized LOC107984190 Neighboring gene uncharacterized LOC107984191 Neighboring gene RNA, 5S ribosomal pseudogene 298 Neighboring gene disco interacting protein 2 homolog C

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Mental retardation, autosomal dominant 30
    MedGen: C4015167 OMIM: 616083 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2018-03-28)

    ClinGen Genome Curation PagePubMed
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated (2018-03-28)

    ClinGen Genome Curation PagePubMed

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC111056

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of transcription elongation from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger MYND domain-containing protein 11
    Names
    adenovirus 5 E1A-binding protein
    bone morphogenetic protein receptor-associated molecule 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029960.1 RefSeqGene

      Range
      5001..125173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202464.1NP_001189393.1  zinc finger MYND domain-containing protein 11 isoform c

      See identical proteins and their annotated locations for NP_001189393.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 16-22, encodes isoform c.
      Source sequence(s)
      AI031881, AY732489, BC091489
      Consensus CDS
      CCDS73060.1
      UniProtKB/Swiss-Prot
      Q15326
      UniProtKB/TrEMBL
      Q5BJG6, Q5UGI2
      Related
      ENSP00000371020.5, ENST00000381607.8
      Conserved Domains (3) summary
      cd05841
      Location:218299
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05492
      Location:104204
      Bromo_ZMYND11; Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene ...
      pfam01753
      Location:509544
      zf-MYND; MYND finger
    2. NM_001202465.1NP_001189394.1  zinc finger MYND domain-containing protein 11 isoform d

      See identical proteins and their annotated locations for NP_001189394.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 23, encodes isoform d.
      Source sequence(s)
      AI031881, AK294469, AY732489, BC091489, DC376390
      Consensus CDS
      CCDS55697.1
      UniProtKB/Swiss-Prot
      Q15326
      UniProtKB/TrEMBL
      Q5BJG6, Q5UGI2
      Related
      ENSP00000381050.3, ENST00000397959.7
      Conserved Domains (3) summary
      cd05841
      Location:187268
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      pfam01753
      Location:478513
      zf-MYND; MYND finger
      cl02556
      Location:95173
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    3. NM_001202466.1NP_001189395.1  zinc finger MYND domain-containing protein 11 isoform e

      See identical proteins and their annotated locations for NP_001189395.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 24, encodes isoform e.
      Source sequence(s)
      AI031881, AK294781, AY732489, BC091489, DC376390
      Consensus CDS
      CCDS73061.1
      UniProtKB/TrEMBL
      B7Z2J6, Q5BJG6, Q5UGI2
      Related
      ENSP00000309992.5, ENST00000309776.8
      Conserved Domains (3) summary
      cd05841
      Location:217298
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05492
      Location:104203
      Bromo_ZMYND11; Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene ...
      pfam01753
      Location:508543
      zf-MYND; MYND finger
    4. NM_001202467.1NP_001189396.1  zinc finger MYND domain-containing protein 11 isoform f

      See identical proteins and their annotated locations for NP_001189396.1

      Status: REVIEWED

      Source sequence(s)
      AI244299, AL589988, BC034784, DB521520, DQ335454
      UniProtKB/Swiss-Prot
      Q15326
      Conserved Domains (2) summary
      cd05841
      Location:218299
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05492
      Location:104204
      Bromo_ZMYND11; Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene ...
    5. NM_001202468.1NP_001189397.1  zinc finger MYND domain-containing protein 11 isoform g

      See identical proteins and their annotated locations for NP_001189397.1

      Status: REVIEWED

      Source sequence(s)
      AI244299, AL589988, BC034784, DB521520, DQ335455
      Consensus CDS
      CCDS55696.1
      UniProtKB/Swiss-Prot
      Q15326
      Related
      ENSP00000452959.1, ENST00000558098.4
      Conserved Domains (3) summary
      cd05841
      Location:272353
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05492
      Location:158258
      Bromo_ZMYND11; Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene ...
      cd15537
      Location:102145
      PHD_BS69; PHD finger found in protein BS69
    6. NM_001330057.1NP_001316986.1  zinc finger MYND domain-containing protein 11 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 25, encodes isoform h.
      Source sequence(s)
      AI031881, AL589988, AL603831, AL713922, AL731539, BM541883, DA600951
      Consensus CDS
      CCDS81436.1
      UniProtKB/TrEMBL
      J3QKD2
      Conserved Domains (4) summary
      cd05841
      Location:255336
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05492
      Location:141241
      Bromo_ZMYND11; Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene ...
      cd15537
      Location:85128
      PHD_BS69; PHD finger found in protein BS69
      pfam01753
      Location:546581
      zf-MYND; MYND finger
    7. NM_001370097.1NP_001357026.1  zinc finger MYND domain-containing protein 11 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 1 and 11-15, encodes the longest isoform (a).
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    8. NM_001370098.1NP_001357027.1  zinc finger MYND domain-containing protein 11 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 1, 10, and 12-15, encodes the longest isoform (a).
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    9. NM_001370099.1NP_001357028.1  zinc finger MYND domain-containing protein 11 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 1, 10, 11, and 13-15, encodes the longest isoform (a).
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    10. NM_001370100.1NP_001357029.1  zinc finger MYND domain-containing protein 11 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 1, 10-12, 14, and 15, encodes the longest isoform (a).
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    11. NM_001370101.1NP_001357030.1  zinc finger MYND domain-containing protein 11 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 1, 10-13, and 15, encodes the longest isoform (a).
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    12. NM_001370102.1NP_001357031.1  zinc finger MYND domain-containing protein 11 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 1 and 10-14, encodes the longest isoform (a).
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    13. NM_001370103.1NP_001357032.1  zinc finger MYND domain-containing protein 11 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 4 and 17-22, encodes isoform c.
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    14. NM_001370104.1NP_001357033.1  zinc finger MYND domain-containing protein 11 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 4, 16, and 18-22, encodes isoform c.
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    15. NM_001370105.1NP_001357034.1  zinc finger MYND domain-containing protein 11 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 4, 16, 17, and 19-22, encodes isoform c.
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    16. NM_001370106.1NP_001357035.1  zinc finger MYND domain-containing protein 11 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 4, 16-18, and 20-22, encodes isoform c.
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    17. NM_001370107.1NP_001357036.1  zinc finger MYND domain-containing protein 11 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 4, 16-19, 21, and 22, encodes isoform c.
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    18. NM_001370108.1NP_001357037.1  zinc finger MYND domain-containing protein 11 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 4, 16-20, and 22, encodes isoform c.
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    19. NM_001370109.1NP_001357038.1  zinc finger MYND domain-containing protein 11 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 4 and 16-21, encodes isoform c.
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    20. NM_001370110.1NP_001357039.1  zinc finger MYND domain-containing protein 11 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variant 5, encodes isoform d.
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    21. NM_001370111.1NP_001357040.1  zinc finger MYND domain-containing protein 11 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variant 6, encodes isoform e.
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    22. NM_001370112.1NP_001357041.1  zinc finger MYND domain-containing protein 11 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variant 9, encodes isoform h.
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    23. NM_001370113.1NP_001357042.1  zinc finger MYND domain-containing protein 11 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variant 27, encodes isoform i.
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    24. NM_001370114.1NP_001357043.1  zinc finger MYND domain-containing protein 11 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27), as well as variant 6, encodes isoform i.
      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    25. NM_001370115.1NP_001357044.1  zinc finger MYND domain-containing protein 11 isoform j

      Status: REVIEWED

      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    26. NM_001370116.1NP_001357045.1  zinc finger MYND domain-containing protein 11 isoform k

      Status: REVIEWED

      Source sequence(s)
      AL589988, AL603831, AL713922
    27. NM_001370117.1NP_001357046.1  zinc finger MYND domain-containing protein 11 isoform l

      Status: REVIEWED

      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    28. NM_001370118.1NP_001357047.1  zinc finger MYND domain-containing protein 11 isoform m

      Status: REVIEWED

      Source sequence(s)
      AL589988, AL603831, AL713922
    29. NM_001370119.1NP_001357048.1  zinc finger MYND domain-containing protein 11 isoform n

      Status: REVIEWED

      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    30. NM_001370120.1NP_001357049.1  zinc finger MYND domain-containing protein 11 isoform o

      Status: REVIEWED

      Source sequence(s)
      AL589988, AL603831, AL713922
    31. NM_001370121.1NP_001357050.1  zinc finger MYND domain-containing protein 11 isoform p

      Status: REVIEWED

      Source sequence(s)
      AL589988, AL603831, AL713922
    32. NM_001370122.1NP_001357051.1  zinc finger MYND domain-containing protein 11 isoform q

      Status: REVIEWED

      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    33. NM_001370123.1NP_001357052.1  zinc finger MYND domain-containing protein 11 isoform r

      Status: REVIEWED

      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539
    34. NM_001370124.1NP_001357053.1  zinc finger MYND domain-containing protein 11 isoform s

      Status: REVIEWED

      Source sequence(s)
      AL589988, AL603831, AL713922
    35. NM_006624.5NP_006615.2  zinc finger MYND domain-containing protein 11 isoform a

      See identical proteins and their annotated locations for NP_006615.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 10-15, encodes the longest isoform (a).
      Source sequence(s)
      AI031881, AK312570, AY732489, BC091489, BP873033
      Consensus CDS
      CCDS7052.2
      UniProtKB/Swiss-Prot
      Q15326
      UniProtKB/TrEMBL
      Q5BJG6, Q5UGI2
      Related
      ENSP00000381053.3, ENST00000397962.8
      Conserved Domains (4) summary
      cd05841
      Location:272353
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05492
      Location:158258
      Bromo_ZMYND11; Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene ...
      cd15537
      Location:102145
      PHD_BS69; PHD finger found in protein BS69
      pfam01753
      Location:563598
      zf-MYND; MYND finger
    36. NM_212479.3NP_997644.2  zinc finger MYND domain-containing protein 11 isoform b

      See identical proteins and their annotated locations for NP_997644.2

      Status: REVIEWED

      Source sequence(s)
      AI244299, AL589988, BC034784, DB521520, DC376390
      Consensus CDS
      CCDS7053.2
      UniProtKB/Swiss-Prot
      Q15326
      Related
      ENSP00000424205.2, ENST00000509513.6
      Conserved Domains (3) summary
      cd05841
      Location:271352
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05492
      Location:158257
      Bromo_ZMYND11; Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene ...
      cd15537
      Location:102145
      PHD_BS69; PHD finger found in protein BS69

    RNA

    1. NR_163254.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL589988, AL603831, AL713922, AL731539

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      130088..254637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015594.1XP_016871083.1  zinc finger MYND domain-containing protein 11 isoform X4

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