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    AHCYL1 adenosylhomocysteinase like 1 [ Homo sapiens (human) ]

    Gene ID: 10768, updated on 24-Dec-2022

    Summary

    Official Symbol
    AHCYL1provided by HGNC
    Official Full Name
    adenosylhomocysteinase like 1provided by HGNC
    Primary source
    HGNC:HGNC:344
    See related
    Ensembl:ENSG00000168710 MIM:607826; AllianceGenome:HGNC:344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA
    Summary
    The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
    Expression
    Ubiquitous expression in brain (RPKM 81.1), duodenum (RPKM 50.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AHCYL1 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (109984765..110023742)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (109994896..110033874)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110527387..110566364)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1768 Neighboring gene Sharpr-MPRA regulatory region 12342 Neighboring gene colony stimulating factor 1 Neighboring gene uncharacterized LOC105378895 Neighboring gene striatin interacting protein 1 Neighboring gene ALX homeobox 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat modulates IRBIT expression in neuron cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables adenosylhomocysteinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in mitochondria-associated endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    S-adenosylhomocysteine hydrolase-like protein 1
    Names
    DC-expressed AHCY-like molecule
    IP(3)Rs binding protein released with IP(3)
    S-adenosyl homocysteine hydrolase homolog
    S-adenosyl-L-homocysteine hydrolase 2
    adenosylhomocysteinase 2
    adoHcyase 2
    dendritic cell expressed AHCY-like protein
    epididymis secretory sperm binding protein
    inositol 1,4,5-trisphosphate receptor-binding protein
    protein phosphatase 1, regulatory subunit 78
    putative adenosylhomocysteinase 2
    NP_001229602.1
    NP_001229603.1
    NP_001229604.1
    NP_001229605.1
    NP_006612.2
    XP_011538837.1
    XP_047296068.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029182.2 RefSeqGene

      Range
      5002..43979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001242673.2NP_001229602.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform b

      See identical proteins and their annotated locations for NP_001229602.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AL772411
      Consensus CDS
      CCDS55620.1
      UniProtKB/Swiss-Prot
      O43865
      Related
      ENSP00000377238.4, ENST00000393614.8
      Conserved Domains (1) summary
      smart00996
      Location:59482
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    2. NM_001242674.2NP_001229603.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform b

      See identical proteins and their annotated locations for NP_001229603.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AA427939, AL772411, BK005417
      Consensus CDS
      CCDS55620.1
      UniProtKB/Swiss-Prot
      O43865
      Conserved Domains (1) summary
      smart00996
      Location:59482
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    3. NM_001242675.2NP_001229604.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform b

      See identical proteins and their annotated locations for NP_001229604.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AA427939, AK316110, AL049954, AL772411, DC328766
      Consensus CDS
      CCDS55620.1
      UniProtKB/Swiss-Prot
      O43865
      Related
      ENSP00000352092.3, ENST00000359172.3
      Conserved Domains (1) summary
      smart00996
      Location:59482
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    4. NM_001242676.2NP_001229605.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform b

      See identical proteins and their annotated locations for NP_001229605.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AA427939, AK316110, AL772411, DC328766
      Consensus CDS
      CCDS55620.1
      UniProtKB/Swiss-Prot
      O43865
      Conserved Domains (1) summary
      smart00996
      Location:59482
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    5. NM_006621.7NP_006612.2  S-adenosylhomocysteine hydrolase-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_006612.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL772411
      Consensus CDS
      CCDS818.1
      UniProtKB/Swiss-Prot
      O43865, Q9UG84
      UniProtKB/TrEMBL
      A0A024R0A8, A0A384N6B4
      Related
      ENSP00000358814.5, ENST00000369799.10
      Conserved Domains (1) summary
      smart00996
      Location:106529
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      109984765..110023742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540535.3XP_011538837.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

      Conserved Domains (2) summary
      smart00996
      Location:106489
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
      PRK05476
      Location:104489
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
    2. XM_047440112.1XP_047296068.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      109994896..110033874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)