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    GRAP GRB2 related adaptor protein [ Homo sapiens (human) ]

    Gene ID: 10750, updated on 17-Sep-2024

    Summary

    Official Symbol
    GRAPprovided by HGNC
    Official Full Name
    GRB2 related adaptor proteinprovided by HGNC
    Primary source
    HGNC:HGNC:4562
    See related
    Ensembl:ENSG00000154016 MIM:604330; AllianceGenome:HGNC:4562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DFNB114
    Summary
    This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]
    Expression
    Broad expression in lymph node (RPKM 19.4), spleen (RPKM 17.2) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GRAP in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (19020656..19051373, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (18968549..18999272, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18923969..18950270, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA MBII-202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18850561-18851174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18851175-18851788 Neighboring gene solute carrier family 5 member 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18864393-18865390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18866439-18866973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18866974-18867507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18871247-18872190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18874077-18875018 Neighboring gene family with sequence similarity 83 member G Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18883844-18884799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18884800-18885754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18885755-18886709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8282 Neighboring gene Sharpr-MPRA regulatory region 2479 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18917397-18918386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18934086-18934883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18935718-18936468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18936469-18937218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18954567-18955068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18955069-18955568 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:18966649-18967243 Neighboring gene small nucleolar RNA, C/D box 3B-1 Neighboring gene small nucleolar RNA, C/D box 3B-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of GRB2-related adaptor protein (GRAP) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC64880

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory perception of sound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in presynapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    GRB2-related adapter protein
    Names
    growth factor receptor-bound protein 2-related adaptor protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330148.2NP_001317077.1  GRB2-related adapter protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AI362516, BC035856, BG684099, BI906472
      Consensus CDS
      CCDS82085.1
      UniProtKB/TrEMBL
      I3L2P9
      Related
      ENSP00000459833.1, ENST00000573099.5
      Conserved Domains (2) summary
      cd11948
      Location:255
      SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
      cl15255
      Location:56101
      SH2; Src homology 2 (SH2) domain
    2. NM_006613.4NP_006604.1  GRB2-related adapter protein isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC003957, BC063035
      Consensus CDS
      CCDS11202.1
      UniProtKB/Swiss-Prot
      Q13588
      Related
      ENSP00000284154.5, ENST00000284154.10
      Conserved Domains (3) summary
      cd09941
      Location:56150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11948
      Location:255
      SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
      cd11951
      Location:162214
      SH3_GRAP_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      19020656..19051373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435154.1XP_047291110.1  GRB2-related adapter protein isoform X1

      UniProtKB/Swiss-Prot
      Q13588
    2. XM_047435155.1XP_047291111.1  GRB2-related adapter protein isoform X2

      UniProtKB/TrEMBL
      I3L2P9
    3. XM_047435156.1XP_047291112.1  GRB2-related adapter protein isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      18968549..18999272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314746.1XP_054170721.1  GRB2-related adapter protein isoform X1

      UniProtKB/Swiss-Prot
      Q13588
    2. XM_054314747.1XP_054170722.1  GRB2-related adapter protein isoform X2

      UniProtKB/TrEMBL
      I3L2P9
    3. XM_054314748.1XP_054170723.1  GRB2-related adapter protein isoform X3