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    IGF2BP2 insulin like growth factor 2 mRNA binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 10644, updated on 15-Jun-2019

    Summary

    Official Symbol
    IGF2BP2provided by HGNC
    Official Full Name
    insulin like growth factor 2 mRNA binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:28867
    See related
    Ensembl:ENSG00000073792 MIM:608289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IMP2; IMP-2; VICKZ2
    Summary
    This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]
    Expression
    Broad expression in placenta (RPKM 4.8), colon (RPKM 4.7) and 24 other tissues See more
    Orthologs

    Genomic context

    See IGF2BP2 in Genome Data Viewer
    Location:
    3q27.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (185643131..185825056, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185361527..185542827, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986055 Neighboring gene SUMO specific peptidase 2 Neighboring gene ribosomal protein L34 pseudogene 10 Neighboring gene IGF2BP2 antisense RNA 1 Neighboring gene microRNA 548aq Neighboring gene transformer 2 beta homolog Neighboring gene NmrA like redox sensor 2, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Diabetes mellitus type 2
    MedGen: C0011860 OMIM: 125853 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    NHGRI GWA Catalog
    A genome-wide association study of gestational diabetes mellitus in Korean women.
    NHGRI GWA Catalog
    A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
    NHGRI GWA Catalog
    Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
    NHGRI GWA Catalog
    Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
    NHGRI GWA Catalog
    Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
    NHGRI GWA Catalog
    Genome-wide association study identifies three novel loci for type 2 diabetes.
    NHGRI GWA Catalog
    Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.
    NHGRI GWA Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    NHGRI GWA Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
    NHGRI GWA Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog
    Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
    NHGRI GWA Catalog
    SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.
    NHGRI GWA Catalog
    Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
    NHGRI GWA Catalog
    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    Rev rev Ectopic expression of IMP1 inhibits replication of HIV-1 in SupT1 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp686I17155

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of cytokine biosynthetic process IC
    Inferred by Curator
    more info
    PubMed 
    regulation of mRNA stability TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    insulin-like growth factor 2 mRNA-binding protein 2
    Names
    IGF-II mRNA-binding protein 2
    IGF2 mRNA-binding protein 2
    VICKZ family member 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011602.1 RefSeqGene

      Range
      4984..186909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007225.3NP_001007226.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform b

      See identical proteins and their annotated locations for NP_001007226.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as p62) is shorter than isoform a.
      Source sequence(s)
      AC016961, AC108670
      Consensus CDS
      CCDS33903.1
      UniProtKB/Swiss-Prot
      Q9Y6M1
      Related
      ENSP00000320204.5, ENST00000346192.7
      Conserved Domains (5) summary
      cd00105
      Location:277342
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:387450
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      cd12626
      Location:278
      RRM1_IGF2BP2; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cd12629
      Location:82157
      RRM2_IGF2BP2; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      pfam00013
      Location:471534
      KH_1; KH domain
    2. NM_001291869.3NP_001278798.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC016961, AC108670
      Consensus CDS
      CCDS77870.1
      UniProtKB/TrEMBL
      F8W930
      Related
      ENSP00000410242.2, ENST00000457616.6
      Conserved Domains (4) summary
      cd00105
      Location:283348
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:436499
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      cd12626
      Location:278
      RRM1_IGF2BP2; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cl17169
      Location:82163
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_001291872.3NP_001278801.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform d

      See identical proteins and their annotated locations for NP_001278801.1

      Status: REVIEWED

      Source sequence(s)
      AC016961, AC108670, AI348863, BC021290, BX106919, EU408701
      UniProtKB/Swiss-Prot
      Q9Y6M1
      Conserved Domains (5) summary
      COG0724
      Location:18140
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00105
      Location:139202
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:373436
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      cl02570
      Location:266311
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17169
      Location:19100
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. NM_001291873.2NP_001278802.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform e

      See identical proteins and their annotated locations for NP_001278802.1

      Status: REVIEWED

      Source sequence(s)
      AC016961, AI348863, BC021290, BX106919, EU408702
      Consensus CDS
      CCDS77869.1
      UniProtKB/Swiss-Prot
      Q9Y6M1
      Related
      ENSP00000413787.3, ENST00000421047.3
      Conserved Domains (4) summary
      cd00105
      Location:214279
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:367430
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      cd12629
      Location:1994
      RRM2_IGF2BP2; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      pfam00013
      Location:451514
      KH_1; KH domain
    5. NM_001291874.3NP_001278803.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform f

      See identical proteins and their annotated locations for NP_001278803.1

      Status: REVIEWED

      Source sequence(s)
      AC016961, AC108670, AI348863, AK296703, BC021290, BX106919, EU408703
      UniProtKB/Swiss-Prot
      Q9Y6M1
      UniProtKB/TrEMBL
      B4DKT5
      Conserved Domains (4) summary
      COG0724
      Location:18134
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00105
      Location:214279
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:324387
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      cd12629
      Location:1994
      RRM2_IGF2BP2; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    6. NM_001291875.3NP_001278804.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC016961, AC108670, AI348863, BC021290, BX106919, EU408704
      UniProtKB/Swiss-Prot
      Q9Y6M1
      UniProtKB/TrEMBL
      B3FTN5
      Conserved Domains (4) summary
      cd00105
      Location:60123
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:294357
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:378441
      KH_1; KH domain
      cl17169
      Location:121
      RRM_SF; RNA recognition motif (RRM) superfamily
    7. NM_006548.6NP_006539.3  insulin-like growth factor 2 mRNA-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_006539.3

      Status: REVIEWED

      Source sequence(s)
      AC016961, AI348863, AK290664, BC021290, BX106919, BY795845
      Consensus CDS
      CCDS3273.2
      UniProtKB/Swiss-Prot
      Q9Y6M1
      Related
      ENSP00000371634.2, ENST00000382199.6
      Conserved Domains (5) summary
      cd00105
      Location:196259
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:430493
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      cd12626
      Location:278
      RRM1_IGF2BP2; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cd12629
      Location:82157
      RRM2_IGF2BP2; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      pfam00013
      Location:514577
      KH_1; KH domain

    RNA

    1. NR_138486.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate segment in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC016961, AC108670

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      185643130..185825056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453316.1XP_024309084.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X7

      Conserved Domains (4) summary
      cd00105
      Location:60123
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:294357
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:378441
      KH_1; KH domain
      cl17169
      Location:121
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. XM_017005560.2XP_016861049.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X4

    3. XM_017005557.2XP_016861046.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X1

    4. XM_017005559.2XP_016861048.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X3

    5. XM_017005558.2XP_016861047.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X2

    6. XM_006713477.4XP_006713540.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X9

      See identical proteins and their annotated locations for XP_006713540.1

      Conserved Domains (3) summary
      cd00105
      Location:2186
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:174237
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      cl02570
      Location:67112
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    7. XM_006713478.4XP_006713541.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X10

      Conserved Domains (2) summary
      cd00105
      Location:2186
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:131194
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    8. XM_017005562.1XP_016861051.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X6

    9. XM_017005561.1XP_016861050.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X5

    10. XM_017005564.1XP_016861053.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X8

    11. XM_017005563.1XP_016861052.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X8

    RNA

    1. XR_001739984.2 RNA Sequence

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