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    POLR3C RNA polymerase III subunit C [ Homo sapiens (human) ]

    Gene ID: 10623, updated on 13-Apr-2024

    Summary

    Official Symbol
    POLR3Cprovided by HGNC
    Official Full Name
    RNA polymerase III subunit Cprovided by HGNC
    Primary source
    HGNC:HGNC:30076
    See related
    Ensembl:ENSG00000186141 MIM:617454; AllianceGenome:HGNC:30076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C82; RPC3; RPC62
    Summary
    Enables single-stranded DNA binding activity. Involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Located in nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 7.3), lymph node (RPKM 3.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    1q21.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (145824200..145844402)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (144941003..144961205)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145590666..145610913, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 1 Neighboring gene NANOG hESC enhancer GRCh37_chr1:145744111-145744612 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:145727451-145728650 Neighboring gene CD160 molecule Neighboring gene ring finger protein 115 Neighboring gene MPRA-validated peak399 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr1:145629590-145630098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1613 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1614 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:145584188-145585387 Neighboring gene nudix hydrolase 17 Neighboring gene microRNA 6736 Neighboring gene protein inhibitor of activated STAT 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    DNA-directed RNA polymerase III subunit RPC3
    Names
    DNA-directed III 62 kDa polypeptide
    DNA-directed RNA polymerase III subunit C
    RNA polymerase III 62 kDa subunit
    RNA polymerase III subunit C3
    polymerase (RNA) III (DNA directed) polypeptide C (62kD)
    polymerase (RNA) III subunit C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303456.1NP_001290385.1  DNA-directed RNA polymerase III subunit RPC3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses an upstream start codon compared to variant 1. It encodes isoform 2 which has a longer and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BC002586, BC053590, BE258456, BQ932484, DA291657, DA816269
      UniProtKB/TrEMBL
      Q53F76
      Conserved Domains (2) summary
      pfam05645
      Location:159358
      RNA_pol_Rpc82; RNA polymerase III subunit RPC82
      pfam08221
      Location:2078
      HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain
    2. NM_006468.8NP_006459.3  DNA-directed RNA polymerase III subunit RPC3 isoform 1

      See identical proteins and their annotated locations for NP_006459.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
      Source sequence(s)
      BC002586, BC053590, BE258456, BI831011, BQ932484, DA291657
      Consensus CDS
      CCDS72864.1
      UniProtKB/Swiss-Prot
      O15317, Q9BUI4, Q9Y3R6
      UniProtKB/TrEMBL
      Q53F76
      Related
      ENSP00000334564.3, ENST00000334163.4
      Conserved Domains (2) summary
      pfam05645
      Location:146345
      RNA_pol_Rpc82; RNA polymerase III subunit RPC82
      pfam08221
      Location:765
      HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      145824200..145844402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433954.1XP_047289910.1  DNA-directed RNA polymerase III subunit RPC3 isoform X2

      Related
      ENSP00000513917.1, ENST00000698761.1
    2. XM_047434013.1XP_047289969.1  DNA-directed RNA polymerase III subunit RPC3 isoform X4

    3. XM_011509078.4XP_011507380.1  DNA-directed RNA polymerase III subunit RPC3 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TNN2
      Conserved Domains (2) summary
      pfam05645
      Location:159332
      RNA_pol_Rpc82; RNA polymerase III subunit RPC82
      pfam08221
      Location:2078
      HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain
    4. XM_047433903.1XP_047289859.1  DNA-directed RNA polymerase III subunit RPC3 isoform X1

      Related
      ENSP00000513915.1, ENST00000698756.1

    RNA

    1. XR_921723.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      144941003..144961205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333885.1XP_054189860.1  DNA-directed RNA polymerase III subunit RPC3 isoform X2

    2. XM_054333887.1XP_054189862.1  DNA-directed RNA polymerase III subunit RPC3 isoform X4

    3. XM_054333886.1XP_054189861.1  DNA-directed RNA polymerase III subunit RPC3 isoform X3

    4. XM_054333884.1XP_054189859.1  DNA-directed RNA polymerase III subunit RPC3 isoform X1

    RNA

    1. XR_008485873.1 RNA Sequence