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    TGOLN2 trans-golgi network protein 2 [ Homo sapiens (human) ]

    Gene ID: 10618, updated on 17-Jun-2019

    Summary

    Official Symbol
    TGOLN2provided by HGNC
    Official Full Name
    trans-golgi network protein 2provided by HGNC
    Primary source
    HGNC:HGNC:15450
    See related
    Ensembl:ENSG00000152291 MIM:603062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TGN38; TGN46; TGN48; TGN51; TTGN2
    Summary
    This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Ubiquitous expression in kidney (RPKM 63.9), thyroid (RPKM 61.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See TGOLN2 in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (85318027..85327989, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85545141..85555419, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transcription factor 7 like 1 Neighboring gene small nuclear ribonucleoprotein E pseudogene Neighboring gene uncharacterized LOC100996506 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene 2 Neighboring gene retinol saturase Neighboring gene ELMO domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag co-localizes with Rab9 and TGN38 in endosomes and trans-Golgi compartments PubMed
    Vpu vpu HIV-1 Vpu co-localizes with the trans-golgi network protein TGN46 in CD4+ T cells PubMed
    vpu Vpu interferes with tetherin trafficking to the cell-surface and causes a relocalization of the cellular tetherin with a TGN marker TGN46 in the TGN PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemRecruitment of plasma membrane-localized cargo into clathrin-coated endocytic vesicles is mediated by interaction with a variety of clathrin-interacting proteins collectively called CLASPs (clathrin-...
    • Clathrin derived vesicle budding, organism-specific biosystem (from REACTOME)
      Clathrin derived vesicle budding, organism-specific biosystemThere at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the cl...
    • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
    • Golgi Associated Vesicle Biogenesis, organism-specific biosystem (from REACTOME)
      Golgi Associated Vesicle Biogenesis, organism-specific biosystemProteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell ...
    • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
      Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Retrograde transport at the Trans-Golgi-Network, organism-specific biosystem (from REACTOME)
      Retrograde transport at the Trans-Golgi-Network, organism-specific biosystemThe trans-Golgi network is the docking site for retrograde cargo from the endolysosomal system and the plasma membrane. Typical cargo includes recycling resident TGN proteins such as TGOLN2 (also kn...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • trans-Golgi Network Vesicle Budding, organism-specific biosystem (from REACTOME)
      trans-Golgi Network Vesicle Budding, organism-specific biosystemAfter passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membran...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC14722

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    membrane organization TAS
    Traceable Author Statement
    more info
     
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated vesicle membrane TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    trans-Golgi network transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transport vesicle TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    trans-Golgi network integral membrane protein 2
    Names
    TGN38 homolog
    trans-Golgi network protein (46, 48, 51kD isoforms)
    trans-Golgi network protein TGN51

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030379.2 RefSeqGene

      Range
      5001..15279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206840.2NP_001193769.1  trans-Golgi network integral membrane protein 2 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, A allele) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1. This variant (2, A allele) differs at 1 nt position compared to variant 2, B allele.
      Source sequence(s)
      AA723637, AC093162, AF027516, AL710137, BC008461, BY798185
      UniProtKB/Swiss-Prot
      O43493
      Related
      ENSP00000387035.1, ENST00000409015.5
      Conserved Domains (1) summary
      PTZ00121
      Location:55330
      PTZ00121; MAEBL; Provisional
    2. NM_001206841.2NP_001193770.1  trans-Golgi network integral membrane protein 2 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, A allele) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a longer and distinct C-terminus, compared to isoform 1. This variant (3, A allele) differs at 1 nt position compared to variant 3, B allele.
      Source sequence(s)
      AA723637, AC093162, AL710137, BC008461, BY798185
      Consensus CDS
      CCDS56126.1
      UniProtKB/Swiss-Prot
      O43493
      Related
      ENSP00000386443.3, ENST00000409232.7
      Conserved Domains (1) summary
      PTZ00121
      Location:55330
      PTZ00121; MAEBL; Provisional
    3. NM_001206844.2NP_001193773.1  trans-Golgi network integral membrane protein 2 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001193773.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and lacks an in-frame segment of the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AA723637, AC093162, BC008461, BX640868
      Consensus CDS
      CCDS56127.1
      UniProtKB/Swiss-Prot
      O43493
      Related
      ENSP00000381312.2, ENST00000398263.6
      Conserved Domains (1) summary
      PLN03237
      Location:64325
      PLN03237; DNA topoisomerase 2; Provisional
    4. NM_001368095.1NP_001355024.1  trans-Golgi network integral membrane protein 2 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, B allele) differs at 1 nt position, resulting in a premature stop codon, compared to variant 2, B allele. The encoded isoform (5) is shorter than isoform 2.
      Source sequence(s)
      AC093162
    5. NM_001368096.1NP_001355025.1  trans-Golgi network integral membrane protein 2 isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, B allele) differs at 1 nt position compared to variant 3, A allele. The encoded isoform (6) is the same length as isoform 3 but differs in sequence by 1 aa.
      Source sequence(s)
      AC093162
    6. NM_006464.4NP_006455.2  trans-Golgi network integral membrane protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_006455.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
      Source sequence(s)
      AA723637, AC093162, AL710137, BC008461
      Consensus CDS
      CCDS46351.1
      UniProtKB/Swiss-Prot
      O43493
      Related
      ENSP00000366603.3, ENST00000377386.8
      Conserved Domains (1) summary
      PTZ00121
      Location:55330
      PTZ00121; MAEBL; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      85318027..85327989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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