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    SPAG5 sperm associated antigen 5 [ Homo sapiens (human) ]

    Gene ID: 10615, updated on 17-Jun-2019

    Summary

    Official Symbol
    SPAG5provided by HGNC
    Official Full Name
    sperm associated antigen 5provided by HGNC
    Primary source
    HGNC:HGNC:13452
    See related
    Ensembl:ENSG00000076382 MIM:615562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAP126; DEEPEST; hMAP126
    Summary
    This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 49.5), bone marrow (RPKM 14.3) and 9 other tissues See more
    Orthologs

    Genomic context

    See SPAG5 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28577574..28599025, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26904583..26926056, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis class S Neighboring gene aldolase, fructose-bisphosphate C Neighboring gene SPAG5 antisense RNA 1 Neighboring gene ribosomal protein S6 kinase related Neighboring gene KIAA0100

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with sperm associated antigen 5 (SPAG5) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: RSKR

    Homology

    Clone Names

    • FLJ78978

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of metaphase plate congression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    centriolar satellite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    condensed chromosome kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sperm-associated antigen 5
    Names
    astrin
    mitotic spindle associated protein p126
    mitotic spindle coiled-coil related protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006461.4NP_006452.3  sperm-associated antigen 5

      See identical proteins and their annotated locations for NP_006452.3

      Status: REVIEWED

      Source sequence(s)
      BC000322, BI459711, BQ773438
      Consensus CDS
      CCDS32594.1
      UniProtKB/Swiss-Prot
      Q96R06
      Related
      ENSP00000323300.5, ENST00000321765.10
      Conserved Domains (2) summary
      COG1196
      Location:5941163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04598
      Location:742944
      Gasdermin; Gasdermin family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      28577574..28599025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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