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    PAIP1 poly(A) binding protein interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 10605, updated on 17-Jun-2019

    Summary

    Official Symbol
    PAIP1provided by HGNC
    Official Full Name
    poly(A) binding protein interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:16945
    See related
    Ensembl:ENSG00000172239 MIM:605184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 24.5), thyroid (RPKM 20.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See PAIP1 in Genome Data Viewer
    Location:
    5p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (43526267..43557419, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43526369..43557521, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 267 Neighboring gene uncharacterized LOC105374749 Neighboring gene chromosome 5 open reading frame 34 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 19 Neighboring gene NNT antisense RNA 1 Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 11344 Neighboring gene nicotinamide nucleotide transhydrogenase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of poly(A) binding protein interacting protein 1 (PAIP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Deadenylation of mRNA, organism-specific biosystem (from REACTOME)
      Deadenylation of mRNA, organism-specific biosystemDeadenylation of mRNA proceeds in two steps. According to current models, in the first step the poly(A) tail is shortened from about 200 adenosine residues to about 80 residues by the PAN2-PAN3 compl...
    • Deadenylation-dependent mRNA decay, organism-specific biosystem (from REACTOME)
      Deadenylation-dependent mRNA decay, organism-specific biosystemAfter undergoing rounds of translation, mRNA is normally destroyed by the deadenylation-dependent pathway. Though the trigger is unclear, deadenylation likely proceeds in two steps: one catalyzed by...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC12360

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    mRNA stabilization TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translational initiation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    polyadenylate-binding protein-interacting protein 1
    Names
    PABC1-interacting protein 1
    PABP-interacting protein 1
    PAIP-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006451.5NP_006442.2  polyadenylate-binding protein-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_006442.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC114956, BC015937, DB089732
      Consensus CDS
      CCDS3947.1
      UniProtKB/Swiss-Prot
      Q9H074
      Related
      ENSP00000302768.3, ENST00000306846.8
      Conserved Domains (2) summary
      pfam02854
      Location:160376
      MIF4G; MIF4G domain
      pfam09030
      Location:44121
      Creb_binding; Creb binding
    2. NM_182789.3NP_877590.1  polyadenylate-binding protein-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_877590.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC114956, AK308270, BC015937
      Consensus CDS
      CCDS47204.1
      UniProtKB/Swiss-Prot
      Q9H074
      Related
      ENSP00000387729.2, ENST00000436644.6
      Conserved Domains (2) summary
      pfam02854
      Location:81297
      MIF4G; MIF4G domain
      pfam07145
      Location:4461
      PAM2; Ataxin-2 C-terminal region
    3. NM_183323.2NP_899152.1  polyadenylate-binding protein-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_899152.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an alternate exon, compared to variant 1, resulting in a different 5' UTR and use of a downstream in-frame start codon. Isoform 3 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC114956, BC015937, DB089732
      Consensus CDS
      CCDS3948.1
      UniProtKB/Swiss-Prot
      Q9H074
      Related
      ENSP00000339622.4, ENST00000338972.8
      Conserved Domains (2) summary
      pfam02854
      Location:48264
      MIF4G; MIF4G domain
      pfam07145
      Location:1128
      PAM2; Ataxin-2 C-terminal region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      43526267..43557419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008956.2XP_016864445.1  polyadenylate-binding protein-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9H074
      Conserved Domains (2) summary
      pfam02854
      Location:48264
      MIF4G; MIF4G domain
      pfam07145
      Location:1128
      PAM2; Ataxin-2 C-terminal region
    2. XM_005248230.4XP_005248287.1  polyadenylate-binding protein-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005248287.1

      UniProtKB/Swiss-Prot
      Q9H074
      Conserved Domains (2) summary
      pfam02854
      Location:48264
      MIF4G; MIF4G domain
      pfam07145
      Location:1128
      PAM2; Ataxin-2 C-terminal region
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