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    SH2B2 SH2B adaptor protein 2 [ Homo sapiens (human) ]

    Gene ID: 10603, updated on 4-Sep-2021

    Summary

    Official Symbol
    SH2B2provided by HGNC
    Official Full Name
    SH2B adaptor protein 2provided by HGNC
    Primary source
    HGNC:HGNC:17381
    See related
    Ensembl:ENSG00000160999 MIM:605300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APS
    Summary
    The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]
    Expression
    Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.2) and 22 other tissues See more
    Orthologs
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    Genomic context

    See SH2B2 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (102285141..102321711)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (101928432..101962178)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cut like homeobox 1 Neighboring gene Sharpr-MPRA regulatory region 6241/11625 Neighboring gene Sharpr-MPRA regulatory region 3063 Neighboring gene uncharacterized LOC107986717 Neighboring gene microRNA 4285 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of SH2B adaptor protein 2 (SH2B2) in human B cells PubMed
    Nef nef Genome-wide shRNA screening identifies SH2B2, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH2 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in B-1 B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antigen receptor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    SH2B adapter protein 2
    Names
    SH2 and PH domain-containing adapter protein APS
    adapter protein with pleckstrin homology and Src homology 2 domains

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033220.1 RefSeqGene

      Range
      5028..41598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001359228.2NP_001346157.1  SH2B adapter protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB000520, AC091390, BI261466, CB053166, HY020205
      Conserved Domains (3) summary
      cd10411
      Location:409504
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:193308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2278
      Phe_ZIP; Phenylalanine zipper
    2. NM_001359229.2NP_001346158.1  SH2B adapter protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB000520, AC091390, BI261466, CB053166
      Conserved Domains (3) summary
      cd10411
      Location:409504
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:193308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2278
      Phe_ZIP; Phenylalanine zipper
    3. NM_001359230.2NP_001346159.1  SH2B adapter protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AA292710, AB000520, AC091390, BI261466, CB053166, HY020205
      Conserved Domains (3) summary
      cd10411
      Location:408503
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:193308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2278
      Phe_ZIP; Phenylalanine zipper
    4. NM_001359231.2NP_001346160.1  SH2B adapter protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AA292710, AB000520, AC091390, BI261466, CB053166
      Conserved Domains (3) summary
      cd10411
      Location:408503
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:193308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2278
      Phe_ZIP; Phenylalanine zipper
    5. NM_001393990.3NP_001380919.2  SH2B adapter protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC091390
      Conserved Domains (3) summary
      cd10411
      Location:408503
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:193308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2278
      Phe_ZIP; Phenylalanine zipper
    6. NM_001393991.3NP_001380920.2  SH2B adapter protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC091390
      Conserved Domains (3) summary
      cd10411
      Location:409504
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:193308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2278
      Phe_ZIP; Phenylalanine zipper
    7. NM_001393992.3NP_001380921.2  SH2B adapter protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC091390
      Conserved Domains (3) summary
      cd10411
      Location:408503
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:193308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2278
      Phe_ZIP; Phenylalanine zipper
    8. NM_001393993.1NP_001380922.1  SH2B adapter protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC091390
      Conserved Domains (3) summary
      cd10411
      Location:409504
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:193308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2278
      Phe_ZIP; Phenylalanine zipper
    9. NM_001393994.1NP_001380923.1  SH2B adapter protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC091390
      Conserved Domains (3) summary
      cd10411
      Location:409504
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:193308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2278
      Phe_ZIP; Phenylalanine zipper
    10. NM_001393995.1NP_001380924.1  SH2B adapter protein 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC091390
      Conserved Domains (2) summary
      cd10411
      Location:191286
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cl17171
      Location:2690
      PH-like; Pleckstrin homology-like domain
    11. NM_001394426.1NP_001381355.1  SH2B adapter protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC091390
      Consensus CDS
      CCDS78264.1
      Conserved Domains (3) summary
      cd10411
      Location:409504
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:193308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2278
      Phe_ZIP; Phenylalanine zipper

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      102285141..102321711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_020979.5: Suppressed sequence

      Description
      NM_020979.5: This RefSeq was removed because currently there is support for the transcript but not for the N-terminus of the protein.
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