U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    IFITM2 interferon induced transmembrane protein 2 [ Homo sapiens (human) ]

    Gene ID: 10581, updated on 5-Mar-2024

    Summary

    Official Symbol
    IFITM2provided by HGNC
    Official Full Name
    interferon induced transmembrane protein 2provided by HGNC
    Primary source
    HGNC:HGNC:5413
    See related
    Ensembl:ENSG00000185201 MIM:605578; AllianceGenome:HGNC:5413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    1-8D; DSPA2c
    Summary
    Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in appendix (RPKM 262.7), spleen (RPKM 209.9) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    11p15.5
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (307816..309395)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (349049..350630)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (307816..309395)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4259 Neighboring gene interferon induced transmembrane protein 5 Neighboring gene mitochondrial ribosomal protein S24 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:305823-306334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:311550-312155 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:313425-313980 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:313981-314536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4266 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:316761-317316 Neighboring gene interferon induced transmembrane protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4267 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:318431-318986 Neighboring gene uncharacterized LOC105376505 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:318987-319542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:320655-321210 Neighboring gene interferon induced transmembrane protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 CXCR4-tropic virus replication is restricted by IFITM2 and IFITM3 as shown through shRNA knockdown PubMed
    HIV-1 CCR5-tropic virus replication is restricted by IFITM1 and IFITM2 as shown through shRNA knockdown PubMed
    HIV-1 infectivity is inhibited when IFITM2 is expressed by the virus producing cell (293T cells) PubMed
    HIV-1 cell-to-cell transmission (Jurkat-to-Jurkat, 293T-to-Jurkat, PM1 to Jurkat, PBMCs to Jurkat) is inhibited by IFITM2 and this inhibition appears to be regulated by the IFITM protein C terminus, is IFITM-species specific and virus-strain specific PubMed
    Knockdown of IFITM1/2/3 by siRNA enhances virus transmission to target cells and the production of virions in CD4+ T cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 interacts with IFITM2 PubMed
    env HIV-1 Env processing from gp160 to gp120/41 is inhibited by IFITM2 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with IFITM2 PubMed
    env IFITM2/3 proteins are co-localize with HIV-1 Env in the cell interior, while surface-associated IFITM2/3 proteins are present at virus budding sites containing HIV-1 Gag and Env proteins in CD4+ T cells PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp120 interacts with IFITM2 PubMed
    env HIV-1 Env processing from gp160 to gp120/41 is inhibited by IFITM2 PubMed
    Nef nef IFITM2 significantly downregulates the expression of HIV-1 Nef by interfering with Tat/TAR-mediated expression PubMed
    Pr55(Gag) gag IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 Gag in virus-producing cells and co-assemble with Gag into budding particles PubMed
    gag Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection PubMed
    gag IFITM2/3 proteins are co-localize with HIV-1 Env in the cell interior, while surface-associated IFITM2/3 proteins are present at virus budding sites containing HIV-1 Gag and Env proteins in CD4+ T cells PubMed
    gag IFITM2 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed
    Vif vif IFITM2 significantly downregulates the expression of HIV-1 Vif by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed
    Vpr vpr HIV-1 Vpr upregulates the expression of IFITM1 in human monocyte-derived dendritic cells PubMed
    vpr IFITM1, 2 or 3 marginally inhibit the entry of HIV-1 NL4-3 and SIV Mac into TZM-bl by measuring the cleavage of CCF2 by BlaM-Vpr that enters the cytoplasm together with viral cores PubMed
    capsid gag IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 CA in velocity gradients, indicating that IFITMs are virion-associated proteins PubMed
    gag Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection PubMed
    gag IFITM2 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cellular response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to interferon-alpha IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to interferon-alpha IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to type II interferon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to type II interferon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    interferon-induced transmembrane protein 2
    Names
    dispanin subfamily A member 2c
    interferon-inducible protein 1-8D

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006435.3NP_006426.2  interferon-induced transmembrane protein 2

      See identical proteins and their annotated locations for NP_006426.2

      Status: VALIDATED

      Source sequence(s)
      AC136475
      Consensus CDS
      CCDS41583.1
      UniProtKB/Swiss-Prot
      Q01629, Q6FH82, Q96DA8
      UniProtKB/TrEMBL
      Q6IBB0
      Related
      ENSP00000484689.1, ENST00000616316.3
      Conserved Domains (1) summary
      pfam04505
      Location:54119
      CD225; Interferon-induced transmembrane protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      307816..309395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      349049..350630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)