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    SLU7 SLU7 homolog, splicing factor [ Homo sapiens (human) ]

    Gene ID: 10569, updated on 19-Jun-2019

    Summary

    Official Symbol
    SLU7provided by HGNC
    Official Full Name
    SLU7 homolog, splicing factorprovided by HGNC
    Primary source
    HGNC:HGNC:16939
    See related
    Ensembl:ENSG00000164609 MIM:605974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    9G8; hSlu7
    Summary
    Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 16.4), thyroid (RPKM 15.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See SLU7 in Genome Data Viewer
    Location:
    5q33.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (160401641..160419081, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159828648..159846168, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene C1q and TNF related 2 Neighboring gene zinc finger BED-type containing 8 Neighboring gene PTTG1 regulator of sister chromatid separation, securin Neighboring gene MIR3142 host gene Neighboring gene microRNA 3142

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of SLU7 splicing factor homolog (SLU7) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem (from REACTOME)
      Cleavage of Growing Transcript in the Termination Region, organism-specific biosystemThis section includes the cleavage of both polyadenylated and non-polyadenylated transcripts. In the former case polyadenylation has to precede transcript cleavage, while in the latter case there is ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
      RNA Polymerase II Transcription, organism-specific biosystem
      RNA Polymerase II Transcription
    • RNA Polymerase II Transcription Termination, organism-specific biosystem (from REACTOME)
      RNA Polymerase II Transcription Termination, organism-specific biosystemThe detailed annotation of this section will be completed in the next release.
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Transport of Mature Transcript to Cytoplasm, organism-specific biosystem (from REACTOME)
      Transport of Mature Transcript to Cytoplasm, organism-specific biosystemTransport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. The separation of the two compartments and the regulation of this tran...
    • Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing. This coupling is achieved by the nuclear p...
    • mRNA 3'-end processing, organism-specific biosystem (from REACTOME)
      mRNA 3'-end processing, organism-specific biosystemThe 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first ...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC9280

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    pre-mRNA 3'-splice site binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to second spliceosomal transesterification activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    second spliceosomal transesterification activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA export from nucleus TAS
    Traceable Author Statement
    more info
     
    RNA splicing, via transesterification reactions IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA 3'-end processing TAS
    Traceable Author Statement
    more info
     
    mRNA 3'-splice site recognition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA export from nucleus TAS
    Traceable Author Statement
    more info
     
    mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    membrane HDA PubMed 
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    small nuclear ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    pre-mRNA-splicing factor SLU7
    Names
    SLU7 splicing factor homolog
    splicing factor
    step II splicing factor SLU7
    zinc knuckle motif containing

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364517.2NP_001351446.1  pre-mRNA-splicing factor SLU7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC091842
      Conserved Domains (1) summary
      pfam11708
      Location:176449
      Slu7; Pre-mRNA splicing Prp18-interacting factor
    2. NM_001364518.2NP_001351447.1  pre-mRNA-splicing factor SLU7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 2, 4, and 5, encodes isoform b.
      Source sequence(s)
      AC091842
      Conserved Domains (1) summary
      pfam11708
      Location:161434
      Slu7; Pre-mRNA splicing Prp18-interacting factor
    3. NM_001364520.2NP_001351449.1  pre-mRNA-splicing factor SLU7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 2, 3, and 5, encodes isoform b.
      Source sequence(s)
      AC091842
      Conserved Domains (1) summary
      pfam11708
      Location:161434
      Slu7; Pre-mRNA splicing Prp18-interacting factor
    4. NM_001364521.2NP_001351450.1  pre-mRNA-splicing factor SLU7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 2-4, encodes isoform b.
      Source sequence(s)
      AC091842
      Conserved Domains (1) summary
      pfam11708
      Location:161434
      Slu7; Pre-mRNA splicing Prp18-interacting factor
    5. NM_001364522.2NP_001351451.1  pre-mRNA-splicing factor SLU7 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 7, encodes isoform c.
      Source sequence(s)
      AC091842
      Conserved Domains (1) summary
      pfam11708
      Location:171444
      Slu7; Pre-mRNA splicing Prp18-interacting factor
    6. NM_001364523.2NP_001351452.1  pre-mRNA-splicing factor SLU7 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 6, encodes isoform c.
      Source sequence(s)
      AC091842
      Conserved Domains (1) summary
      pfam11708
      Location:171444
      Slu7; Pre-mRNA splicing Prp18-interacting factor
    7. NM_006425.5NP_006416.3  pre-mRNA-splicing factor SLU7 isoform b

      See identical proteins and their annotated locations for NP_006416.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 3-5, encodes isoform b.
      Source sequence(s)
      AC091842, BC010634, BE221264, CA976106, DA232975, DA409854
      Consensus CDS
      CCDS4352.1
      UniProtKB/Swiss-Prot
      O95391
      Related
      ENSP00000297151.4, ENST00000297151.9
      Conserved Domains (1) summary
      pfam11708
      Location:161434
      Slu7; Pre-mRNA splicing Prp18-interacting factor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      160401641..160419081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024454327.1XP_024310095.1  pre-mRNA-splicing factor SLU7 isoform X2

      Conserved Domains (1) summary
      pfam11708
      Location:161434
      Slu7; Pre-mRNA splicing Prp18-interacting factor
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