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    OLFM4 olfactomedin 4 [ Homo sapiens (human) ]

    Gene ID: 10562, updated on 12-Oct-2019

    Summary

    Official Symbol
    OLFM4provided by HGNC
    Official Full Name
    olfactomedin 4provided by HGNC
    Primary source
    HGNC:HGNC:17190
    See related
    Ensembl:ENSG00000102837 MIM:614061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GC1; OLM4; OlfD; GW112; hGC-1; hOLfD; UNQ362; bA209J19.1
    Summary
    This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
    Expression
    Biased expression in small intestine (RPKM 721.2), duodenum (RPKM 639.8) and 4 other tissues See more
    Orthologs

    Genomic context

    See OLFM4 in Genome Data Viewer
    Location:
    13q14.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (53028813..53052057)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (53602876..53626196)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8029 Neighboring gene protocadherin 8 Neighboring gene long intergenic non-protein coding RNA 1065 Neighboring gene protocadherin 8 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association meta-analysis identifies new childhood obesity loci.
    NHGRI GWA Catalog
    A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.
    NHGRI GWA Catalog
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4294

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homooligomerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of necrotic cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of neutrophil extravasation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    NOT azurophil granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    extracellular exosome HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space HDA PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    specific granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    specific granule lumen TAS
    Traceable Author Statement
    more info
     
    tertiary granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    olfactomedin-4
    Names
    G-CSF-stimulated clone 1 protein
    antiapoptotic protein GW112

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006418.5NP_006409.3  olfactomedin-4 precursor

      See identical proteins and their annotated locations for NP_006409.3

      Status: REVIEWED

      Source sequence(s)
      AI560739, AY358567, DA928098
      Consensus CDS
      CCDS9440.1
      UniProtKB/Swiss-Prot
      Q6UX06
      UniProtKB/TrEMBL
      A0A024QZ95
      Related
      ENSP00000219022.2, ENST00000219022.3
      Conserved Domains (2) summary
      pfam02191
      Location:251503
      OLF; Olfactomedin-like domain
      cl25732
      Location:98233
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      53028813..53052057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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