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    IFI44 interferon induced protein 44 [ Homo sapiens (human) ]

    Gene ID: 10561, updated on 17-Jun-2019

    Summary

    Official Symbol
    IFI44provided by HGNC
    Official Full Name
    interferon induced protein 44provided by HGNC
    Primary source
    HGNC:HGNC:16938
    See related
    Ensembl:ENSG00000137965 MIM:610468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p44; TLDC5; MTAP44
    Expression
    Broad expression in bone marrow (RPKM 19.2), spleen (RPKM 17.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See IFI44 in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (78648943..78664078)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (79115477..79129763)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene prostaglandin F receptor Neighboring gene interferon induced protein 44 like Neighboring gene ribosomal protein L23 pseudogene 3 Neighboring gene SNW domain containing 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of interferon-induced protein 44 (IFI44) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of interferon-inducible protein 44 (IFI44) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including MTAp44, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    interferon-induced protein 44
    Names
    TBC/LysM-associated domain containing 5
    interferon-induced, hepatitis C-associated microtubular aggregate protein (44kD)
    microtubule-associated protein 44

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006417.5NP_006408.3  interferon-induced protein 44

      See identical proteins and their annotated locations for NP_006408.3

      Status: VALIDATED

      Source sequence(s)
      BC022870, CA426666, DC300799, DN994910
      Consensus CDS
      CCDS688.1
      UniProtKB/Swiss-Prot
      Q8TCB0
      Related
      ENSP00000359783.4, ENST00000370747.9
      Conserved Domains (1) summary
      cl02144
      Location:2887
      TLD; TLD

    RNA

    1. NR_135640.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI061108, AK316476, AL589497, BC022870
      Related
      ENST00000472152.5
    2. NR_135641.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI061108, AK316476, AL589497, BC022870

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      78648943..78664078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540516.3XP_011538818.1  interferon-induced protein 44 isoform X1

      Conserved Domains (1) summary
      cl02144
      Location:2870
      TLD; TLD
    2. XM_005270380.4XP_005270437.1  interferon-induced protein 44 isoform X3

      Conserved Domains (1) summary
      cl02144
      Location:2870
      TLD; TLD
    3. XM_017000083.2XP_016855572.1  interferon-induced protein 44 isoform X2

    RNA

    1. XR_001736919.2 RNA Sequence

    2. XR_426586.4 RNA Sequence

    3. XR_001736922.2 RNA Sequence

    4. XR_001736920.2 RNA Sequence

    5. XR_001736921.2 RNA Sequence

    6. XR_001736923.2 RNA Sequence

    7. XR_001736924.2 RNA Sequence

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