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    CEBPB CCAAT enhancer binding protein beta [ Homo sapiens (human) ]

    Gene ID: 1051, updated on 9-Dec-2024

    Summary

    Official Symbol
    CEBPBprovided by HGNC
    Official Full Name
    CCAAT enhancer binding protein betaprovided by HGNC
    Primary source
    HGNC:HGNC:1834
    See related
    Ensembl:ENSG00000172216 MIM:189965; AllianceGenome:HGNC:1834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCF5; IL6DBP; NF-IL6; C/EBP-beta
    Summary
    This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
    Orthologs
    NEW
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    Genomic context

    See CEBPB in Genome Data Viewer
    Location:
    20q13.13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (50190583..50192690)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (51960086..51962193)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48807120..48809227)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:48782079-48783278 Neighboring gene long intergenic non-protein coding RNA 1275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48788805-48789306 Neighboring gene long intergenic non-protein coding RNA 1273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48795707-48796206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18084 Neighboring gene CEBPB antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13015 Neighboring gene Sharpr-MPRA regulatory region 92 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48810074-48810635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48814475-48814992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48814993-48815508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48840734-48841234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48841235-48841735 Neighboring gene Sharpr-MPRA regulatory region 4966 Neighboring gene uncharacterized LOC107985386 Neighboring gene uncharacterized LOC105372656 Neighboring gene MPRA-validated peak4248 silencer

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates C/EBPbeta expression in human mesenchymal stem cells PubMed
    Tat tat The gene expression of CCAAT/enhancer binding protein beta is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells PubMed
    tat The synergistic interaction between C/EBPbeta-2 and Tat with the subtype C LTR is observed in U-937 cells PubMed
    tat Tat-C/EBPbeta association is mediated through cdk9, which phosphorylates C/EBPbeta PubMed
    tat Specific C/EBP and NF-kappaB transcription factor binding elements within the IL-1beta promoter are involved in Tat regulation of IL-1beta production PubMed
    tat Interaction between TGF-beta signaling proteins Smad-3 and Smad-4, and C/EBPbeta modulates basal and HIV-1 Tat-mediated transcription of the HIV-1 LTR promoter in astrocytes PubMed
    tat Interaction of C/EBPbeta and HIV-1 Tat stimulates MCP-1 transcription in astrocytes PubMed
    tat HIV-1 Tat induces an increase in C/EBPbeta binding activity through a direct binding interaction between Tat and C/EBPbeta that is mediated through the N-terminal, cysteine rich, and core regions of Tat (amino acids 1-47) PubMed
    tat HIV-1 Tat upregulates IL-6 expression by transactivating the IL-6 promoter, an effect mediated through enhancement of CAAT enhancer-binding protein (C/EBP; nuclear factor-IL-6) DNA binding activity PubMed
    tat HIV-1 Tat induces iNOS in human astroglia through the activation of NF-kappaB and C/EBPbeta, an effect that may participate in the pathogenesis of HIV-associated dementia PubMed
    Vif vif NF-IL6 facilitates the reverse transcription of HIV-1 by binding to and inhibiting the antiviral cytidine deaminase APOBEC3G. A mutation in NF-IL6 at Ser-288 weakens its binding to APOBEC3G and strongly inhibits HIV-1 replication PubMed
    Vpr vpr HIV-1 Vpr-induced retrotransposition of long interspersed element-1 depends on an AhR-MAPK/p38-C/EBP-beta cascade via the LQQLL motif of Vpr PubMed
    vpr HIV-1 Vpr-induced IL-6 production depends on the activation of NFkappaB and the involvement of C/EBP-beta, TLR4, and MyD88 PubMed
    vpr Upregulation of IL-6, IL-10, TNFalpha, and gamma interferon is linked to HIV-1 Vpr activation of NF-IL-6 PubMed
    vpr HIV-1 Vpr activates NF-IL-6 resulting in an increase in IL-8 expression and IL-8 promoter activity and also increases transcription of NF-IL-6 enhancer-containing viral promoters PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC32080

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II core promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone acetyltransferase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-like protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in T-helper 1 cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in acute-phase response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in embryonic placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in granuloma formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hepatocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in integrated stress response signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in liver regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mammary gland epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mammary gland epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myeloid cell development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ovarian follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of biomineral tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of biomineral tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-4 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of sodium-dependent phosphate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of sodium-dependent phosphate transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II EXP
    Inferred from Experiment
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of dendritic cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of odontoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of osteoclast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of C/EBP complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of CHOP-C/EBP complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of CHOP-C/EBP complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex EXP
    Inferred from Experiment
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in condensed chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    CCAAT/enhancer-binding protein beta
    Names
    CCAAT/enhancer binding protein (C/EBP), beta
    interleukin 6-dependent DNA-binding protein
    nuclear factor NF-IL6
    nuclear factor of interleukin 6
    transcription factor 5
    transcription factor C/EBP beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029019.1 RefSeqGene

      Range
      4992..6830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001285878.1NP_001272807.1  CCAAT/enhancer-binding protein beta isoform b

      Status: REVIEWED

      Source sequence(s)
      AW025406, BC007538, DB457615
      UniProtKB/Swiss-Prot
      P17676
      Conserved Domains (1) summary
      cd14712
      Location:241311
      bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain
    2. NM_001285879.1NP_001272808.1  CCAAT/enhancer-binding protein beta isoform c

      Status: REVIEWED

      Source sequence(s)
      AW025406, BC007538, DB457615
      UniProtKB/TrEMBL
      Q9BSC0
      Conserved Domains (1) summary
      cd14712
      Location:66136
      bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain
    3. NM_005194.4NP_005185.2  CCAAT/enhancer-binding protein beta isoform a

      See identical proteins and their annotated locations for NP_005185.2

      Status: REVIEWED

      Source sequence(s)
      BC007538, DB457615
      Consensus CDS
      CCDS13429.1
      UniProtKB/Swiss-Prot
      A8K671, P17676, Q96IH2, Q9H4Z5
      Related
      ENSP00000305422.3, ENST00000303004.5
      Conserved Domains (1) summary
      cd14712
      Location:264334
      bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      50190583..50192690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      51960086..51962193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)