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    TADA3 transcriptional adaptor 3 [ Homo sapiens (human) ]

    Gene ID: 10474, updated on 17-Jun-2019

    Summary

    Official Symbol
    TADA3provided by HGNC
    Official Full Name
    transcriptional adaptor 3provided by HGNC
    Primary source
    HGNC:HGNC:19422
    See related
    Ensembl:ENSG00000171148 MIM:602945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADA3; NGG1; hADA3; STAF54; TADA3L
    Summary
    DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
    Expression
    Ubiquitous expression in testis (RPKM 21.9), ovary (RPKM 20.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See TADA3 in Genome Data Viewer
    Location:
    3p25.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (9779964..9793011, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9821648..9834695, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene bromodomain and PHD finger containing 1 Neighboring gene 8-oxoguanine DNA glycosylase Neighboring gene calcium/calmodulin dependent protein kinase I Neighboring gene ARPC4-TTLL3 readthrough Neighboring gene actin related protein 2/3 complex subunit 4 Neighboring gene tubulin tyrosine ligase like 3 Neighboring gene RNA pseudouridine synthase D3 Neighboring gene microtubule affinity regulating kinase 2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
      Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
    • Chromatin organization, organism-specific biosystem (from REACTOME)
      Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • HATs acetylate histones, organism-specific biosystem (from REACTOME)
      HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
      Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20221, FLJ21329

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nuclear receptor transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    histone H3 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H3 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H4 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular estrogen receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    regulation of histone deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of tubulin deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Ada2/Gcn5/Ada3 transcription activator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Ada2/Gcn5/Ada3 transcription activator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    STAGA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor TFTC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcriptional adapter 3
    Names
    ADA3 homolog
    ADA3-like protein
    alteration/deficiency in activation 3
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278270.1NP_001265199.1  transcriptional adapter 3 isoform a

      See identical proteins and their annotated locations for NP_001265199.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (a).
      Source sequence(s)
      AA602644, AK292264, BC009240, BC013433
      Consensus CDS
      CCDS2583.1
      UniProtKB/Swiss-Prot
      O75528
      UniProtKB/TrEMBL
      A8K899
      Related
      ENSP00000393471.1, ENST00000440161.5
      Conserved Domains (1) summary
      pfam10198
      Location:309422
      Ada3; Histone acetyltransferases subunit 3
    2. NM_006354.3NP_006345.1  transcriptional adapter 3 isoform a

      See identical proteins and their annotated locations for NP_006345.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer protein. Variants 1 and 3 encode the same isoform (a).
      Source sequence(s)
      AA602644, AC022382, AK292264, BC009240, BC013433, BM560517, DB032623
      Consensus CDS
      CCDS2583.1
      UniProtKB/Swiss-Prot
      O75528
      UniProtKB/TrEMBL
      A8K899
      Related
      ENSP00000307684.2, ENST00000301964.6
      Conserved Domains (1) summary
      pfam10198
      Location:309422
      Ada3; Histone acetyltransferases subunit 3
    3. NM_133480.2NP_597814.1  transcriptional adapter 3 isoform b

      See identical proteins and their annotated locations for NP_597814.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1, that results in an early stop codon and a different 3' UTR, compared to variant 1. It encodes isoform b which is shorter at the C-terminus, compared to isoform a.
      Source sequence(s)
      AC022382, AK292264, BC009240, BM560517, DB032623
      Consensus CDS
      CCDS2584.1
      UniProtKB/Swiss-Prot
      O75528
      UniProtKB/TrEMBL
      A0A024R2D7, A8K899
      Related
      ENSP00000343649.2, ENST00000343450.2
      Conserved Domains (1) summary
      pfam10198
      Location:309368
      Ada3; Histone acetyltransferases subunit 3

    RNA

    1. NR_103488.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate internal exons and uses alternate splice sites in the 5' terminal exon and in an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA602644, AC022382, AK292264, BC013433, BG477633

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      9779964..9793011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_133481.1: Suppressed sequence

      Description
      NM_133481.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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