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    BAIAP2 BAR/IMD domain containing adaptor protein 2 [ Homo sapiens (human) ]

    Gene ID: 10458, updated on 5-Sep-2021

    Summary

    Official Symbol
    BAIAP2provided by HGNC
    Official Full Name
    BAR/IMD domain containing adaptor protein 2provided by HGNC
    Primary source
    HGNC:HGNC:947
    See related
    Ensembl:ENSG00000175866 MIM:605475
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAP2; WAML; FLAF3; IRSP53
    Summary
    The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
    Expression
    Broad expression in brain (RPKM 10.7), skin (RPKM 9.8) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See BAIAP2 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81035131..81117434)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79008951..79091234)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100129503 Neighboring gene BAIAP2 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 8367 Neighboring gene uncharacterized LOC107987250 Neighboring gene Sharpr-MPRA regulatory region 11647 Neighboring gene apoptosis associated tyrosine kinase Neighboring gene microRNA 657

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    BAIAP2 is related to emotional modulation of human memory strength.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 VLP production/release from Jurkat T lymphocytes requires an intact RAC1-WASF2-BAIAP2-ARP3 pathway as demonstrated by siRNA knockdown experiments PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Downregulation of the Wave2 signaling complex (Tiam-1, Abl, Rac, IRSp53, Wave2, and Arp3) with siRNA reduces HIV-1 Env-mediated cell-cell fusion and virus-cell fusion PubMed
    Pr55(Gag) gag HIV-1 Gag is required by RAC1-WASF2-BAIAP2-ARP3 pathway for HIV VLP production/release from Jurkat T lymphocytes PubMed
    gag HIV-1 Gag intracellular localization is modulated by WASF2 and BAIAP2 as demonstrated by double siRNA knockdowns of these cellular proteins (in Jurkat T cells) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cadherin binding involved in cell-cell adhesion HDA PubMed 
    enables cytoskeletal anchor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proline-rich region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein C-terminus binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coregulator binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin crosslink formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin filament bundle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axonogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to L-glutamate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in modification of synaptic structure, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of actin cytoskeleton reorganization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to synapse IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of modification of postsynaptic actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in adherens junction HDA PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in excitatory synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection branch point IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection terminus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in postsynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density, intracellular component IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    brain-specific angiogenesis inhibitor 1-associated protein 2
    Names
    BAI1 associated protein 2
    IRS-58
    IRSp53/58
    WASP and MIM like
    fas ligand-associated factor 3
    insulin receptor substrate of 53 kDa
    insulin receptor substrate p53/p58
    insulin receptor substrate protein of 53 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029486.2 RefSeqGene

      Range
      5005..87288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144888.2NP_001138360.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001138360.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) shares identical sequence with variants 1, 2 and 3, but diverges after amino acid 511 resulting in a distinct 23 amino acid sequence at the C-terminus. This transcript variant encodes isoform 4 and is alternatively referred to as variant M.
      Source sequence(s)
      AC115099, BC002495, CB153324
      Consensus CDS
      CCDS45806.1
      UniProtKB/Swiss-Prot
      Q9UQB8
      Related
      ENSP00000401022.2, ENST00000428708.7
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    2. NM_001385127.1NP_001372056.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    3. NM_001385128.1NP_001372057.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 3, encodes isoform 3.
      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    4. NM_001385129.1NP_001372058.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:410468
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    5. NM_001385130.1NP_001372059.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:410468
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    6. NM_001385131.1NP_001372060.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    7. NM_001385132.1NP_001372061.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:410468
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    8. NM_001385133.1NP_001372062.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:411469
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    9. NM_001385134.1NP_001372063.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:410468
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    10. NM_001385135.1NP_001372064.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:411469
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    11. NM_001385136.1NP_001372065.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Related
      ENSP00000461144.1, ENST00000575245.5
      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:410468
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    12. NM_001385137.1NP_001372066.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5261
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:403461
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    13. NM_001385138.1NP_001372067.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:378436
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    14. NM_001385139.1NP_001372068.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    15. NM_001385140.1NP_001372069.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:378436
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    16. NM_001385141.1NP_001372070.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:378436
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    17. NM_001385144.1NP_001372073.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5234
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:375433
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    18. NM_001385145.1NP_001372074.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 19

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variant 22, encodes isoform 19.
      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    19. NM_001385146.1NP_001372075.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 19

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variant 21, encodes isoform 19.
      Source sequence(s)
      AC115099, AC127496
      Related
      ENSP00000458964.1, ENST00000575712.5
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    20. NM_001385147.1NP_001372076.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC115099
      Conserved Domains (2) summary
      cd11915
      Location:319377
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1178
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    21. NM_001385148.1NP_001372077.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 21

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variant 25, encodes isoform 21.
      Source sequence(s)
      AC115099, AC127496
      Conserved Domains (2) summary
      cd11915
      Location:319377
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1178
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    22. NM_001385149.1NP_001372078.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 21

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variant 24, encodes isoform 21.
      Source sequence(s)
      AC115099
      Conserved Domains (2) summary
      cd11915
      Location:319377
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1178
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    23. NM_001385150.1NP_001372079.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC115099
      Conserved Domains (2) summary
      cd11915
      Location:299357
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1158
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    24. NM_001385151.1NP_001372080.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC115099
      Conserved Domains (2) summary
      cd11915
      Location:300358
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1158
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    25. NM_001385152.1NP_001372081.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 24

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28), as well as variant 29, encodes isoform 24.
      Source sequence(s)
      AC115099
      Conserved Domains (2) summary
      cd11915
      Location:299357
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1158
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    26. NM_001385153.1NP_001372082.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 24

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29), as well as variant 28, encodes isoform 24.
      Source sequence(s)
      AC115099
      Conserved Domains (2) summary
      cd11915
      Location:299357
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1158
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    27. NM_001385154.1NP_001372083.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 25

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variants 31 and 32, encodes isoform 25.
      Source sequence(s)
      AC115099
      Conserved Domains (2) summary
      cd11915
      Location:299357
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1158
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    28. NM_001385155.1NP_001372084.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 25

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31), as well as variants 30 and 32, encodes isoform 25.
      Source sequence(s)
      AC115099
      Conserved Domains (2) summary
      cd11915
      Location:299357
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1158
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    29. NM_001385156.1NP_001372085.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 25

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32), as well as variants 30 and 31, encodes isoform 25.
      Source sequence(s)
      AC115099
      Conserved Domains (2) summary
      cd11915
      Location:299357
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1158
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    30. NM_001385157.1NP_001372086.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC115099
      Conserved Domains (1) summary
      cd11915
      Location:134192
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    31. NM_001385158.1NP_001372087.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (34), as well as variant 35, encodes isoform 27.
      Source sequence(s)
      AC115099
      Conserved Domains (1) summary
      cd11915
      Location:134192
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    32. NM_001385159.1NP_001372088.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (35), as well as variant 34, encodes isoform 27.
      Source sequence(s)
      AC115099
      Conserved Domains (1) summary
      cd11915
      Location:134192
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    33. NM_006340.3NP_006331.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 3

      See identical proteins and their annotated locations for NP_006331.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) shares identical sequence with variants 1, 2 and 4, but diverges after amino acid 511 resulting in a distinct 9 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as BAP2-beta or variant T. Variants 3 and 6 both encode the same isoform (3).
      Source sequence(s)
      AB015020, AC115099, BC002495, CB153324
      Consensus CDS
      CCDS11776.1
      UniProtKB/Swiss-Prot
      Q9UQB8
      Related
      ENSP00000413069.3, ENST00000435091.7
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    34. NM_017450.3NP_059344.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_059344.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) shares identical sequence with variants 2, 3 and 4, but diverges after amino acid 511 resulting in a distinct 10 amino acid sequence at the C-terminus. This transcript variant encodes isoform 1 and is alternatively referred to as BAP2-alpha, short form, or variant S.
      Source sequence(s)
      AC115099, BC002495, CB153324
      Consensus CDS
      CCDS11777.1
      UniProtKB/Swiss-Prot
      Q9UQB8
      Related
      ENSP00000315685.7, ENST00000321280.11
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    35. NM_017451.3NP_059345.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 2

      See identical proteins and their annotated locations for NP_059345.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) shares identical sequence with variants 1, 3 and 4, but diverges after amino acid 511 resulting in a distinct 41 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as the long form or variant L. Variants 2 and 5 both encode the same isoform (2).
      Source sequence(s)
      AC115099, BC002495, CB153324
      Consensus CDS
      CCDS11775.1
      UniProtKB/Swiss-Prot
      Q9UQB8
      Related
      ENSP00000316338.6, ENST00000321300.10
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

    RNA

    1. NR_169574.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
    2. NR_169575.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
    3. NR_169576.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
    4. NR_169577.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
    5. NR_169578.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
    6. NR_169579.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC115099, AC127496
    7. NR_169580.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC115099

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      81035131..81117434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450534.1XP_024306302.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X10

      Conserved Domains (2) summary
      cd11915
      Location:378436
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:95237
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_011524194.1XP_011522496.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1

      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:411469
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    3. XM_011524193.1XP_011522495.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X5

      See identical proteins and their annotated locations for XP_011522495.1

      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:411469
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    4. XM_017024017.1XP_016879506.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X8

    5. XM_017024018.1XP_016879507.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X11

      Conserved Domains (2) summary
      cd11915
      Location:300358
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1158
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    6. XM_024450535.1XP_024306303.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X11

      Conserved Domains (2) summary
      cd11915
      Location:300358
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1158
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    7. XM_017024019.1XP_016879508.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X12

      Conserved Domains (1) summary
      cd11915
      Location:135193
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    8. XM_011524195.1XP_011522497.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X12

      See identical proteins and their annotated locations for XP_011522497.1

      Conserved Domains (1) summary
      cd11915
      Location:135193
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    9. XM_011524196.1XP_011522498.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X12

      See identical proteins and their annotated locations for XP_011522498.1

      Conserved Domains (1) summary
      cd11915
      Location:135193
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
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