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    C1D C1D nuclear receptor corepressor [ Homo sapiens (human) ]

    Gene ID: 10438, updated on 17-Jun-2019

    Summary

    Official Symbol
    C1Dprovided by HGNC
    Official Full Name
    C1D nuclear receptor corepressorprovided by HGNC
    Primary source
    HGNC:HGNC:29911
    See related
    Ensembl:ENSG00000197223 MIM:606997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR
    Summary
    The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in bone marrow (RPKM 17.9), adrenal (RPKM 15.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See C1D in Genome Data Viewer
    Location:
    2p14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (68041130..68063004, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68269332..68290159, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1812 Neighboring gene F-box and leucine rich repeat protein 12 pseudogene Neighboring gene uncharacterized LOC105374789 Neighboring gene small integral membrane protein 30-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif modulates the expression of C1D nuclear receptor corepressor (C1D) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystem (from REACTOME)
      Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
    • RNA degradation, organism-specific biosystem (from KEGG)
      RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • RNA degradation, conserved biosystem (from KEGG)
      RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • rRNA processing, organism-specific biosystem (from REACTOME)
      rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
    • rRNA processing in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
      rRNA processing in the nucleus and cytosol, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC12261, MGC14659

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    maturation of 5.8S rRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    rRNA processing TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear exosome (RNase complex) TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    transcriptional repressor complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nuclear nucleic acid-binding protein C1D
    Names
    C1D DNA-binding protein
    C1D nuclear receptor co-repressor
    nuclear DNA-binding protein
    small unique nuclear receptor co-repressor
    small unique nuclear receptor corepressor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190263.2NP_001177192.1  nuclear nucleic acid-binding protein C1D

      See identical proteins and their annotated locations for NP_001177192.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC079112, AI004680, AK290451
      Consensus CDS
      CCDS1883.1
      UniProtKB/Swiss-Prot
      Q13901
      Related
      ENSP00000386779.1, ENST00000409302.1
      Conserved Domains (1) summary
      pfam04000
      Location:1895
      Sas10_Utp3; Sas10/Utp3/C1D family
    2. NM_001190265.2NP_001177194.1  nuclear nucleic acid-binding protein C1D

      See identical proteins and their annotated locations for NP_001177194.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC079112, AI004680, DA900336
      Consensus CDS
      CCDS1883.1
      UniProtKB/Swiss-Prot
      Q13901
      Conserved Domains (1) summary
      pfam04000
      Location:1895
      Sas10_Utp3; Sas10/Utp3/C1D family
    3. NM_006333.4NP_006324.1  nuclear nucleic acid-binding protein C1D

      See identical proteins and their annotated locations for NP_006324.1

      Status: REVIEWED

      Description
      Transcript Variant: This transcript represents variant (1). Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC079112, BC016284, BG505686, BM354091, CN342947
      Consensus CDS
      CCDS1883.1
      UniProtKB/Swiss-Prot
      Q13901
      Related
      ENSP00000348107.3, ENST00000355848.7
      Conserved Domains (1) summary
      pfam04000
      Location:1895
      Sas10_Utp3; Sas10/Utp3/C1D family
    4. NM_173177.3NP_775269.1  nuclear nucleic acid-binding protein C1D

      See identical proteins and their annotated locations for NP_775269.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC079112, BC009589, BG505686, BM354091, CN342947
      Consensus CDS
      CCDS1883.1
      UniProtKB/Swiss-Prot
      Q13901
      Related
      ENSP00000386468.3, ENST00000410067.7
      Conserved Domains (1) summary
      pfam04000
      Location:1895
      Sas10_Utp3; Sas10/Utp3/C1D family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      68041130..68063004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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