TRAIP TRAF interacting protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRAIPprovided by HGNC
Official Full Name: TRAF interacting proteinprovided by HGNC
Primary source: HGNC:HGNC:30764
See related: Ensembl:ENSG00000183763 MIM:605958; AllianceGenome:HGNC:30764
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRIP; SCKL9; RNF206
Summary: This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 4.0), bone marrow (RPKM 2.3) and 23 other tissues See more
Orthologs: all
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Genomic context

Location:: 3p21.31

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (49828601..49856564, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (49858496..49886461, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (49866034..49893997, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2-PI3K-AKT pathway activation.
Title: TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2-PI3K-AKT pathway activation.
TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells.
Title: TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells.
ZNF212 promotes genomic integrity through direct interaction with TRAIP.
Title: ZNF212 promotes genomic integrity through direct interaction with TRAIP.
Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT.
Title: Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT.
TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation.
Title: TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation.
The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome.
Title: The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome.
TRIP suppresses cell proliferation and invasion in choroidal melanoma via promoting the proteasomal degradation of Twist1.
Title: TRIP suppresses cell proliferation and invasion in choroidal melanoma via promoting the proteasomal degradation of Twist1.
TRAIP promotes malignant behaviors and correlates with poor prognosis in liver cancer.
Title: TRAIP promotes malignant behaviors and correlates with poor prognosis in liver cancer.
TRAIP is important for the recruitment of NEIL3 but not FANCD2, and knockdown of TRAIP promotes FA/BRCA pathway activation. Interestingly, TRAIP is non-epistatic with both NEIL3 and FA pathways in psoralen-ICL repair, suggesting that TRAIP may function upstream of the two pathways.
Title: Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair.
present results, together with other recent findings, establish TRAIP as a master regulator of DNA helicase CMG unloading and the response of the replisome to obstacles
Title: TRAIP is a master regulator of DNA interstrand crosslink repair.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Seckel syndrome 9 MedGen: C4225212 OMIM: 616777 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G65744 (e-PCR)
- UniSTS:166701

RH11809 (e-PCR)
- UniSTS:81505

SHGC-149851 (e-PCR)
- UniSTS:183687

WI-15318 (e-PCR)
- UniSTS:77516

WI-13434 (e-PCR)
- UniSTS:61435

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	EXP Inferred from Experiment more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of interferon-beta production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein-DNA covalent cross-linking repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication fork processing	IDA Inferred from Direct Assay more info	PubMed
involved_in replication fork processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	EXP Inferred from Experiment more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
part_of nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
is_active_in site of DNA damage	IBA Inferred from Biological aspect of Ancestor more info
located_in site of DNA damage	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRAIP

Names: RING-type E3 ubiquitin transferase TRAIP; ring finger protein 206

NP_005870.2

EC 2.3.2.27

XP_016861015.1

EC 2.3.2.27

XP_047303196.1

EC 2.3.2.27

XP_054200892.1

EC 2.3.2.27

XP_054200893.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_046695.1 RefSeqGene

Range

4996..32959

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_005879.3 → NP_005870.2 E3 ubiquitin-protein ligase TRAIP

See identical proteins and their annotated locations for NP_005870.2

Status: REVIEWED

Source sequence(s)

AC139451, BC019283, BQ446539, BX473682

Consensus CDS

CCDS2806.1

UniProtKB/Swiss-Prot

B5BU84, B5BUL3, O00467, Q9BWF2

UniProtKB/TrEMBL

A0ACI8THM7, A0ACI8TIW2, A8K807

Related

ENSP00000328203.2, ENST00000331456.7

Conserved Domains (2) summary

cd16480
Location:6 → 50

RING-H2_TRAIP; RING finger, H2 subclass, found in TRAF-interacting protein (TRAIP) and similar proteins

cl25732
Location:68 → 279

SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

49828601..49856564 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017005526.2 → XP_016861015.1 E3 ubiquitin-protein ligase TRAIP isoform X1

UniProtKB/TrEMBL

A0ACI8QEI7, A0ACI8TIF6

Related

ENSP00000561907.1, ENST00000891848.1
XM_047447240.1 → XP_047303196.1 E3 ubiquitin-protein ligase TRAIP isoform X2

RNA

XR_007094382.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

49858496..49886461 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054344917.1 → XP_054200892.1 E3 ubiquitin-protein ligase TRAIP isoform X1

UniProtKB/TrEMBL

A0ACI8QEI7, A0ACI8TIF6
XM_054344918.1 → XP_054200893.1 E3 ubiquitin-protein ligase TRAIP isoform X2