Format

Send to:

Choose Destination
    • Showing Current items.

    RAMP2 receptor activity modifying protein 2 [ Homo sapiens (human) ]

    Gene ID: 10266, updated on 12-May-2019

    Summary

    Official Symbol
    RAMP2provided by HGNC
    Official Full Name
    receptor activity modifying protein 2provided by HGNC
    Primary source
    HGNC:HGNC:9844
    See related
    Ensembl:ENSG00000131477 MIM:605154
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lung (RPKM 58.9), fat (RPKM 57.7) and 22 other tissues See more
    Orthologs

    Genomic context

    See RAMP2 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (42761194..42763041)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40913145..40915063)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene enhancer of zeste 1 polycomb repressive complex 2 subunit Neighboring gene ribosomal protein L34 pseudogene 30 Neighboring gene RAMP2 antisense RNA 1 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 15 Neighboring gene vacuolar protein sorting 25 homolog Neighboring gene WNK lysine deficient protein kinase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Calcitonin-like ligand receptors, organism-specific biosystem (from REACTOME)
      Calcitonin-like ligand receptors, organism-specific biosystemThe calcitonin peptide family comprises calcitonin, amylin, calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and intermedin (AM2). Calcitonin is a 32 amino acid peptide, involved in bone h...
    • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
      Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    adrenomedullin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    adrenomedullin receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to amylin receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    coreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    coreceptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    adherens junction assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adrenomedullin receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    amylin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basement membrane assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    bicellular tight junction assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to vascular endothelial growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of endothelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of vascular permeability IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    vascular smooth muscle cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    adrenomedullin receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    amylin receptor complex 2 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated pit TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    lysosome TAS
    Traceable Author Statement
    more info
    PubMed 
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    receptor activity-modifying protein 2
    Names
    CRLR activity-modifying protein 2
    calcitonin receptor-like receptor activity modifying protein 2
    receptor (G protein-coupled) activity modifying protein 2
    receptor (calcitonin) activity modifying protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005854.3NP_005845.2  receptor activity-modifying protein 2 precursor

      See identical proteins and their annotated locations for NP_005845.2

      Status: REVIEWED

      Source sequence(s)
      AL548945, BC027975
      Consensus CDS
      CCDS11437.1
      UniProtKB/Swiss-Prot
      O60895
      UniProtKB/TrEMBL
      A0A024R1Z2
      Related
      ENSP00000253796.3, ENST00000253796.10
      Conserved Domains (1) summary
      pfam04901
      Location:65172
      RAMP; Receptor activity modifying family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      42761194..42763041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center