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    MPHOSPH10 M-phase phosphoprotein 10 [ Homo sapiens (human) ]

    Gene ID: 10199, updated on 17-Jun-2024

    Summary

    Official Symbol
    MPHOSPH10provided by HGNC
    Official Full Name
    M-phase phosphoprotein 10provided by HGNC
    Primary source
    HGNC:HGNC:7213
    See related
    Ensembl:ENSG00000124383 MIM:605503; AllianceGenome:HGNC:7213
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT90; MPP10; MPP10P; PPP1R106
    Summary
    This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in esophagus (RPKM 13.3), prostate (RPKM 12.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MPHOSPH10 in Genome Data Viewer
    Location:
    2p13.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (71130634..71150101)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (71141674..71161134)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (71357764..71377231)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71310886-71311700 Neighboring gene NANOG hESC enhancer GRCh37_chr2:71317686-71318275 Neighboring gene N-acetylglucosamine kinase Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:71330180-71330990 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71345289-71345789 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71356582-71357440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16015 Neighboring gene methylmalonyl-CoA epimerase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16016 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:71384714-71384875 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:71388687-71389348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71411093-71411594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71411595-71412094 Neighboring gene poly(A) binding protein interacting protein 2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71453663-71454163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16017 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71477764-71478264 Neighboring gene uncharacterized LOC105374797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11622

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in RNA splicing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in RNA splicing, via transesterification reactions NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in maturation of SSU-rRNA NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Mpp10 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Mpp10 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of sno(s)RNA-containing ribonucleoprotein complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    U3 small nucleolar ribonucleoprotein protein MPP10
    Names
    U3 small nucleolar ribonucleoprotein
    m phase phosphoprotein 10
    protein phosphatase 1, regulatory subunit 106

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005791.3NP_005782.1  U3 small nucleolar ribonucleoprotein protein MPP10

      See identical proteins and their annotated locations for NP_005782.1

      Status: REVIEWED

      Source sequence(s)
      BC041084, BC126389
      Consensus CDS
      CCDS1916.1
      UniProtKB/Swiss-Prot
      A0AVJ8, O00566
      UniProtKB/TrEMBL
      B3KPV5
      Related
      ENSP00000244230.2, ENST00000244230.7
      Conserved Domains (1) summary
      pfam04006
      Location:22632
      Mpp10; Mpp10 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      71130634..71150101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      71141674..71161134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)