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    PRMT3 protein arginine methyltransferase 3 [ Homo sapiens (human) ]

    Gene ID: 10196, updated on 21-Dec-2019

    Summary

    Official Symbol
    PRMT3provided by HGNC
    Official Full Name
    protein arginine methyltransferase 3provided by HGNC
    Primary source
    HGNC:HGNC:30163
    See related
    Ensembl:ENSG00000185238 MIM:603190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HRMT1L3
    Summary
    This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.5), brain (RPKM 3.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See PRMT3 in Genome Data Viewer
    Location:
    11p15.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (20387530..20510861)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (20409076..20530879)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376583 Neighboring gene NFE2L2 motif-containing MPRA enhancer 64 Neighboring gene HIV-1 Tat interactive protein 2 Neighboring gene uncharacterized LOC105376584 Neighboring gene high mobility group box 1 pseudogene 40

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of protein arginine methyltransferase 3 (PRMT3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-arginine N-methyltransferase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein-arginine N-methyltransferase activity TAS
    Traceable Author Statement
    more info
     
    ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-arginine N-methylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein methylation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    protein arginine N-methyltransferase 3
    Names
    HMT1 hnRNP methyltransferase-like 3
    heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145166.1NP_001138638.1  protein arginine N-methyltransferase 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is missing two non-consecutive internal coding exons compared to transcript variant 1. It uses the same translation start site as variant 1, however, the first missing exon throws it out of frame, and the second missing exon puts it back in frame, resulting in a shorter isoform (2) with a novel 28 aa segment compared to isoform 1.
      Source sequence(s)
      BC019339, CA428457, DA163907, DB510248
      Consensus CDS
      CCDS44554.1
      UniProtKB/TrEMBL
      A0A0A0MSN7, Q8WUV3
      Related
      ENSP00000397766.2, ENST00000437750.2
      Conserved Domains (1) summary
      cd02440
      Location:197297
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001145167.1NP_001138639.1  protein arginine N-methyltransferase 3 isoform 3

      See identical proteins and their annotated locations for NP_001138639.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) is missing a coding exon at the 5' end compared to transcript variant 1. This results in translation initiation from an in-frame downstream AUG by leaky scanning, and a shorter isoform (3) with a truncated N-terminus compared to isoform 1.
      Source sequence(s)
      BC019339, CA428457, DA163907, DB510248
      UniProtKB/TrEMBL
      Q8WUV3
      Conserved Domains (1) summary
      cd02440
      Location:182282
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_005788.4NP_005779.1  protein arginine N-methyltransferase 3 isoform 1

      See identical proteins and their annotated locations for NP_005779.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC025972, AC108005, KC877396, KF459543
      Consensus CDS
      CCDS7853.1
      UniProtKB/Swiss-Prot
      O60678
      Related
      ENSP00000331879.6, ENST00000331079.11
      Conserved Domains (1) summary
      cd02440
      Location:259359
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      20387530..20510861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448312.1XP_024304080.1  protein arginine N-methyltransferase 3 isoform X3

      Conserved Domains (1) summary
      cd02440
      Location:95195
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_017017081.1XP_016872570.1  protein arginine N-methyltransferase 3 isoform X1

    3. XM_011519836.2XP_011518138.1  protein arginine N-methyltransferase 3 isoform X2

      Conserved Domains (1) summary
      cd02440
      Location:154254
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_001747718.2 RNA Sequence

    2. XR_002957114.1 RNA Sequence

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