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    TNK2 tyrosine kinase non receptor 2 [ Homo sapiens (human) ]

    Gene ID: 10188, updated on 10-Oct-2024

    Summary

    Official Symbol
    TNK2provided by HGNC
    Official Full Name
    tyrosine kinase non receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:19297
    See related
    Ensembl:ENSG00000061938 MIM:606994; AllianceGenome:HGNC:19297
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACK; ACK1; ACK-1; p21cdc42Hs
    Summary
    This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 21.9), bone marrow (RPKM 14.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TNK2 in Genome Data Viewer
    Location:
    3q29
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (195863364..195908551, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (198449491..198494501)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195590235..195635422, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene vegetative cell wall protein gp1-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195543301-195544106 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:195547535-195548734 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr3:195550530-195551217 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_67540 and experimental_67545 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_67549, experimental_67550 and experimental_67551 Neighboring gene MPRA-validated peak4987 silencer Neighboring gene uncharacterized LOC107984010 Neighboring gene long intergenic non-protein coding RNA 1983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195577694-195578194 Neighboring gene kinesin family member 3A pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195586662-195587186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195587187-195587709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195604399-195604953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195610157-195610657 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195613501-195614264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195615031-195615794 Neighboring gene microRNA 6829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195623973-195624772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195625602-195626282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21063 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195641665-195642277 Neighboring gene TNK2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195652784-195653752 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195653753-195654721 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195654722-195655690 Neighboring gene RNA, U2 small nuclear 11, pseudogene Neighboring gene mucin-5AC-like Neighboring gene serine/threonine-protein phosphatase 4 regulatory subunit 2-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ44758, FLJ45547

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables WW domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables epidermal growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Grb2-EGFR complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoophidium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    activated CDC42 kinase 1
    Names
    activated Cdc42-associated kinase 1
    activated p21cdc42Hs kinase
    tyrosine kinase non-receptor protein 2
    NP_001010938.2
    NP_001294975.1
    NP_001369200.1
    NP_001369201.1
    NP_001369202.1
    NP_001369203.1
    NP_001369204.1
    NP_001373093.1
    NP_001374636.1
    NP_001374637.1
    NP_001374638.1
    NP_001374639.1
    NP_001374640.1
    NP_001374641.1
    NP_001374642.1
    NP_001374643.1
    NP_001374644.1
    NP_001374645.1
    NP_001374646.1
    NP_001374647.1
    NP_001374648.1
    NP_001374649.1
    NP_001374650.1
    NP_005772.3
    XP_011510619.2
    XP_011510620.2
    XP_011510623.1
    XP_016860998.1
    XP_024309059.2
    XP_024309060.1
    XP_024309061.1
    XP_024309063.1
    XP_047303097.1
    XP_047303098.1
    XP_047303099.1
    XP_047303100.1
    XP_047303101.1
    XP_047303102.1
    XP_047303103.1
    XP_047303104.1
    XP_047303105.1
    XP_047303106.1
    XP_047303107.1
    XP_047303108.1
    XP_047303109.1
    XP_047303110.1
    XP_047303111.1
    XP_047303112.1
    XP_047303113.1
    XP_047303114.1
    XP_047303115.1
    XP_047303116.1
    XP_047303117.1
    XP_047303118.1
    XP_047303119.1
    XP_047303120.1
    XP_047303121.1
    XP_047303122.1
    XP_054200826.1
    XP_054200827.1
    XP_054200828.1
    XP_054200829.1
    XP_054200830.1
    XP_054200831.1
    XP_054200832.1
    XP_054200833.1
    XP_054200834.1
    XP_054200835.1
    XP_054200836.1
    XP_054200837.1
    XP_054200838.1
    XP_054200839.1
    XP_054200840.1
    XP_054200841.1
    XP_054200842.1
    XP_054200843.1
    XP_054200844.1
    XP_054200845.1
    XP_054200846.1
    XP_054200847.1
    XP_054200848.1
    XP_054200849.1
    XP_054200850.1
    XP_054200851.1
    XP_054200852.1
    XP_054200853.1
    XP_054200854.1
    XP_054200855.1
    XP_054200856.1
    XP_054200857.1
    XP_054200858.1
    XP_054200859.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029779.1 RefSeqGene

      Range
      5459..50646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001010938.2NP_001010938.2  activated CDC42 kinase 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a distinct 5' UTR and 5' coding region, lacks one alternate 3' coding exon, and contains a different alternate 3' coding exon, as compared to variant 1. The translation remains in-frame, and results in a longer isoform (2) that has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK127455, AK131539, BC020395, L13738
      Consensus CDS
      CCDS33927.2
      UniProtKB/TrEMBL
      A0A499FJ16
      Related
      ENSP00000499858.1, ENST00000671753.1
      Conserved Domains (7) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:582888
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:9981037
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473538
      GTPase_binding; GTPase binding
      pfam11555
      Location:813879
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    2. NM_001308046.2NP_001294975.1  activated CDC42 kinase 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate 5' exon, contains an alternate 5' terminal exon, lacks one alternate 3' coding exon, and initiates translation at an alternate start codon, compared to variant 1. It encodes a shorter isoform (3) that has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS77875.1
      UniProtKB/TrEMBL
      A0A499FJ16, C9J1X3
      Related
      ENSP00000392546.1, ENST00000428187.7
      Conserved Domains (7) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:158417
      STYKc; Protein kinase; unclassified specificity
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    3. NM_001382271.1NP_001369200.1  activated CDC42 kinase 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93443.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZHJ2
      Related
      ENSP00000503221.1, ENST00000678220.1
      Conserved Domains (8) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:575881
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9931036
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10231062
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    4. NM_001382272.1NP_001369201.1  activated CDC42 kinase 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (8) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:582888
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:10001043
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10301069
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473538
      GTPase_binding; GTPase binding
      pfam11555
      Location:813877
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    5. NM_001382273.1NP_001369202.1  activated CDC42 kinase 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93442.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZGX5
      Related
      ENSP00000499899.1, ENST00000672887.2
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9761019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    6. NM_001382274.1NP_001369203.1  activated CDC42 kinase 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93442.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZGX5
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9761019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    7. NM_001382275.1NP_001369204.1  activated CDC42 kinase 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (7) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:590896
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    8. NM_001386164.1NP_001373093.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93441.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZI29
      Related
      ENSP00000500887.1, ENST00000673420.1
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9611004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    9. NM_001387707.1NP_001374636.1  activated CDC42 kinase 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (8) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:590896
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:10081051
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10381077
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    10. NM_001387708.1NP_001374637.1  activated CDC42 kinase 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (8) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:567873
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9851028
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10151054
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473538
      GTPase_binding; GTPase binding
      pfam11555
      Location:798862
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    11. NM_001387709.1NP_001374638.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93441.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZI29
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9611004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    12. NM_001387710.1NP_001374639.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93441.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZI29
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9611004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    13. NM_001387711.1NP_001374640.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93441.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZI29
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9611004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    14. NM_001387712.1NP_001374641.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93441.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZI29
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9611004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    15. NM_001387713.1NP_001374642.1  activated CDC42 kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS33928.1
      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9581002
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9891028
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    16. NM_001387714.1NP_001374643.1  activated CDC42 kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS33928.1
      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9581002
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9891028
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    17. NM_001387715.1NP_001374644.1  activated CDC42 kinase 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (7) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:567873
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:9831022
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473538
      GTPase_binding; GTPase binding
      pfam11555
      Location:798862
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    18. NM_001387716.1NP_001374645.1  activated CDC42 kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (7) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:9741013
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    19. NM_001387717.1NP_001374646.1  activated CDC42 kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (7) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:9741013
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    20. NM_001387718.1NP_001374647.1  activated CDC42 kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (7) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:9741013
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    21. NM_001387719.1NP_001374648.1  activated CDC42 kinase 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93440.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZHP4
      Conserved Domains (7) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:959998
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    22. NM_001387720.1NP_001374649.1  activated CDC42 kinase 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93440.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZHP4
      Related
      ENSP00000500486.1, ENST00000672024.1
      Conserved Domains (7) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:959998
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    23. NM_001387721.1NP_001374650.1  activated CDC42 kinase 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93440.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZHP4
      Conserved Domains (7) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:959998
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    24. NM_005781.5NP_005772.3  activated CDC42 kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_005772.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the more frequently occurring transcript and it encodes isoform 1.
      Source sequence(s)
      AC124944, AK127455, AK131539, BG742978, CN411136, L13738
      Consensus CDS
      CCDS33928.1
      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59
      UniProtKB/TrEMBL
      A0A499FJ16
      Related
      ENSP00000329425.6, ENST00000333602.14
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9581002
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9891028
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain

    RNA

    1. NR_170678.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    2. NR_170679.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    3. NR_170680.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    4. NR_170681.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    5. NR_170682.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    6. NR_170683.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    7. NR_170684.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    8. NR_170685.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    9. NR_170686.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    10. NR_170687.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    11. NR_170688.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    12. NR_170689.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    13. NR_170690.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    14. NR_170691.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    15. NR_170692.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      195863364..195908551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447154.1XP_047303110.1  activated CDC42 kinase 1 isoform X15

    2. XM_047447157.1XP_047303113.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5
    3. XM_047447153.1XP_047303109.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A5F9ZHJ2
    4. XM_047447161.1XP_047303117.1  activated CDC42 kinase 1 isoform X19

    5. XM_047447143.1XP_047303099.1  activated CDC42 kinase 1 isoform X1

    6. XM_047447142.1XP_047303098.1  activated CDC42 kinase 1 isoform X1

    7. XM_047447162.1XP_047303118.1  activated CDC42 kinase 1 isoform X20

    8. XM_047447156.1XP_047303112.1  activated CDC42 kinase 1 isoform X17

    9. XM_024453292.2XP_024309060.1  activated CDC42 kinase 1 isoform X14

      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (6) summary
      cd09539
      Location:2384
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:410461
      SH3; Src homology 3 domains
      PHA03247
      Location:575881
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9931036
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10231062
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:147404
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    10. XM_047447150.1XP_047303106.1  activated CDC42 kinase 1 isoform X11

    11. XM_047447160.1XP_047303116.1  activated CDC42 kinase 1 isoform X13

      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59
    12. XM_047447159.1XP_047303115.1  activated CDC42 kinase 1 isoform X18

      UniProtKB/TrEMBL
      A0A5F9ZI29
    13. XM_047447158.1XP_047303114.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5
    14. XM_024453295.2XP_024309063.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZGX5
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9761019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    15. XM_047447141.1XP_047303097.1  activated CDC42 kinase 1 isoform X1

    16. XM_047447151.1XP_047303107.1  activated CDC42 kinase 1 isoform X13

      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59
    17. XM_024453291.2XP_024309059.2  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5
    18. XM_047447148.1XP_047303104.1  activated CDC42 kinase 1 isoform X9

      UniProtKB/TrEMBL
      C9J1X3
    19. XM_047447146.1XP_047303102.1  activated CDC42 kinase 1 isoform X6

    20. XM_047447145.1XP_047303101.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A5F9ZHJ2
    21. XM_047447147.1XP_047303103.1  activated CDC42 kinase 1 isoform X8

    22. XM_011512318.3XP_011510620.2  activated CDC42 kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A499FJ16
    23. XM_011512317.4XP_011510619.2  activated CDC42 kinase 1 isoform X2

    24. XM_047447152.1XP_047303108.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A5F9ZHJ2
    25. XM_024453293.2XP_024309061.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZGX5
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9761019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    26. XM_047447155.1XP_047303111.1  activated CDC42 kinase 1 isoform X16

    27. XM_047447163.1XP_047303119.1  activated CDC42 kinase 1 isoform X22

    28. XM_011512321.2XP_011510623.1  activated CDC42 kinase 1 isoform X21

      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (7) summary
      smart00221
      Location:50309
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:900943
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:930969
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:54311
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:371438
      GTPase_binding; GTPase binding
      pfam11555
      Location:713777
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:319368
      SH3_9; Variant SH3 domain
    29. XM_047447164.1XP_047303120.1  activated CDC42 kinase 1 isoform X23

    30. XM_047447165.1XP_047303121.1  activated CDC42 kinase 1 isoform X23

    31. XM_047447166.1XP_047303122.1  activated CDC42 kinase 1 isoform X24

      UniProtKB/TrEMBL
      B3KXJ4
      Related
      ENSP00000500238.1, ENST00000672548.1
    32. XM_047447149.1XP_047303105.1  activated CDC42 kinase 1 isoform X10

    33. XM_017005509.2XP_016860998.1  activated CDC42 kinase 1 isoform X7

      UniProtKB/TrEMBL
      A0A499FJ16
    34. XM_047447144.1XP_047303100.1  activated CDC42 kinase 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      198449491..198494501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344851.1XP_054200826.1  activated CDC42 kinase 1 isoform X1

    2. XM_054344852.1XP_054200827.1  activated CDC42 kinase 1 isoform X1

    3. XM_054344877.1XP_054200852.1  activated CDC42 kinase 1 isoform X19

    4. XM_054344867.1XP_054200842.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A5F9ZHJ2
    5. XM_054344872.1XP_054200847.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5
    6. XM_054344862.1XP_054200837.1  activated CDC42 kinase 1 isoform X11

    7. XM_054344865.1XP_054200840.1  activated CDC42 kinase 1 isoform X14

    8. XM_054344869.1XP_054200844.1  activated CDC42 kinase 1 isoform X17

    9. XM_054344878.1XP_054200853.1  activated CDC42 kinase 1 isoform X20

    10. XM_054344875.1XP_054200850.1  activated CDC42 kinase 1 isoform X18

      UniProtKB/TrEMBL
      A0A5F9ZI29
    11. XM_054344876.1XP_054200851.1  activated CDC42 kinase 1 isoform X13

      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59
    12. XM_054344873.1XP_054200848.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5
    13. XM_054344874.1XP_054200849.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5
    14. XM_054344871.1XP_054200846.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5
    15. XM_054344855.1XP_054200830.1  activated CDC42 kinase 1 isoform X4

    16. XM_054344859.1XP_054200834.1  activated CDC42 kinase 1 isoform X8

    17. XM_054344856.1XP_054200831.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A5F9ZHJ2
    18. XM_054344857.1XP_054200832.1  activated CDC42 kinase 1 isoform X6

    19. XM_054344860.1XP_054200835.1  activated CDC42 kinase 1 isoform X9

      UniProtKB/TrEMBL
      C9J1X3
    20. XM_054344863.1XP_054200838.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5
    21. XM_054344864.1XP_054200839.1  activated CDC42 kinase 1 isoform X13

      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59
    22. XM_054344854.1XP_054200829.1  activated CDC42 kinase 1 isoform X3

    23. XM_054344858.1XP_054200833.1  activated CDC42 kinase 1 isoform X7

    24. XM_054344861.1XP_054200836.1  activated CDC42 kinase 1 isoform X10

    25. XM_054344866.1XP_054200841.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A5F9ZHJ2
    26. XM_054344853.1XP_054200828.1  activated CDC42 kinase 1 isoform X2

    27. XM_054344870.1XP_054200845.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5
    28. XM_054344868.1XP_054200843.1  activated CDC42 kinase 1 isoform X16

    29. XM_054344879.1XP_054200854.1  activated CDC42 kinase 1 isoform X21

    30. XM_054344880.1XP_054200855.1  activated CDC42 kinase 1 isoform X22

    31. XM_054344881.1XP_054200856.1  activated CDC42 kinase 1 isoform X23

    32. XM_054344882.1XP_054200857.1  activated CDC42 kinase 1 isoform X23

    33. XM_054344883.1XP_054200858.1  activated CDC42 kinase 1 isoform X24

      UniProtKB/TrEMBL
      B3KXJ4
    34. XM_054344884.1XP_054200859.1  activated CDC42 kinase 1 isoform X24

      UniProtKB/TrEMBL
      B3KXJ4