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    SERF2 small EDRK-rich factor 2 [ Homo sapiens (human) ]

    Gene ID: 10169, updated on 11-Jun-2021

    Summary

    Official Symbol
    SERF2provided by HGNC
    Official Full Name
    small EDRK-rich factor 2provided by HGNC
    Primary source
    HGNC:HGNC:10757
    See related
    Ensembl:ENSG00000140264 MIM:605054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM2C; 4F5REL; H4F5REL; HsT17089
    Expression
    Ubiquitous expression in prostate (RPKM 57.5), colon (RPKM 53.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See SERF2 in Genome Data Viewer
    Location:
    15q15.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (43777086..43796089)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (44069284..44088287)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated 2 pseudogene 1 Neighboring gene protein disulfide isomerase family A member 3 Neighboring gene elongation factor for RNA polymerase II 3 Neighboring gene SERF2-C15orf63 readthrough Neighboring gene microRNA 1282 Neighboring gene serine incorporator 4 Neighboring gene huntingtin interacting protein K Neighboring gene microfibril associated protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20431, FLJ37527, FLJ38557, MGC48826

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    small EDRK-rich factor 2
    Names
    gastric cancer-related protein VRG107
    protein 4F5-related

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018108.4NP_001018118.1  small EDRK-rich factor 2 isoform c

      See identical proteins and their annotated locations for NP_001018118.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct and shorter C-terminus, compared to isoform a. Both variants 3 and 4 encode isoform c.
      Source sequence(s)
      AC018512, BC008214, BM970646
      Consensus CDS
      CCDS32218.1
      UniProtKB/Swiss-Prot
      P84101
      Related
      ENSP00000249786.4, ENST00000249786.9
      Conserved Domains (1) summary
      pfam04419
      Location:137
      4F5; 4F5 protein family
    2. NM_001199875.1NP_001186804.1  small EDRK-rich factor 2 isoform a

      See identical proteins and their annotated locations for NP_001186804.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC018512, AK307547, BC009869, BM970646
      Consensus CDS
      CCDS55963.1
      UniProtKB/Swiss-Prot
      P84101
      Related
      ENSP00000387187.2, ENST00000409960.6
      Conserved Domains (1) summary
      pfam04419
      Location:137
      4F5; 4F5 protein family
    3. NM_001199876.1NP_001186805.1  small EDRK-rich factor 2 isoform b

      See identical proteins and their annotated locations for NP_001186805.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AC018512, BC009869, BM970646, BP317864
      Consensus CDS
      CCDS55964.1
      UniProtKB/Swiss-Prot
      P84101
      Related
      ENSP00000339647.5, ENST00000339624.9
      Conserved Domains (1) summary
      pfam04419
      Location:137
      4F5; 4F5 protein family
    4. NM_001199877.2NP_001186806.1  small EDRK-rich factor 2 isoform c

      See identical proteins and their annotated locations for NP_001186806.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct and shorter C-terminus, compared to isoform a. Both variants 3 and 4 encode isoform c.
      Source sequence(s)
      AC018512, BC009869, BM970646, BQ061048
      Consensus CDS
      CCDS32218.1
      UniProtKB/Swiss-Prot
      P84101
      Related
      ENSP00000370764.1, ENST00000381359.5
      Conserved Domains (1) summary
      pfam04419
      Location:137
      4F5; 4F5 protein family
    5. NM_001199878.2NP_001186807.1  small EDRK-rich factor 2 isoform d

      See identical proteins and their annotated locations for NP_001186807.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC018512, BI260545, BM970646, DA302996
      Consensus CDS
      CCDS55965.1
      UniProtKB/Swiss-Prot
      P84101
      Related
      ENSP00000384300.1, ENST00000403425.5

    RNA

    1. NR_037672.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site and lacks a segment of the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC018512, BC009869, BM970646, DB060650

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      43777086..43796089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005770.5: Suppressed sequence

      Description
      NM_005770.5: This RefSeq was permanently suppressed because it contains the wrong CDS.
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