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    CHST4 carbohydrate sulfotransferase 4 [ Homo sapiens (human) ]

    Gene ID: 10164, updated on 18-Sep-2024

    Summary

    Official Symbol
    CHST4provided by HGNC
    Official Full Name
    carbohydrate sulfotransferase 4provided by HGNC
    Primary source
    HGNC:HGNC:1972
    See related
    Ensembl:ENSG00000140835 AllianceGenome:HGNC:1972
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GST3; LSST; GlcNAc6ST2; HECGLCNAC6ST
    Summary
    This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
    Expression
    Restricted expression toward gall bladder (RPKM 42.6) See more
    Orthologs
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    Genomic context

    See CHST4 in Genome Data Viewer
    Location:
    16q22.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (71526120..71538748)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (77343320..77355947)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (71560023..71572651)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:71507841-71509040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11075 Neighboring gene zinc finger protein 19 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:71517771-71518680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7679 Neighboring gene uncharacterized LOC105371335 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:71559962-71560572 Neighboring gene Sharpr-MPRA regulatory region 3479 Neighboring gene NANOG hESC enhancer GRCh37_chr16:71595643-71596144 Neighboring gene uncharacterized LOC124903710 Neighboring gene RNA, U6 small nuclear 1061, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in N-acetylglucosamine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in O-glycan processing TAS
    Traceable Author Statement
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of leukocyte tethering or rolling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein sulfation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sulfur compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sulfur compound metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    carbohydrate sulfotransferase 4
    Names
    GST-3
    HEC-GlcNAc6ST
    L-selectin ligand sulfotransferase
    N-acetylglucosamine 6-O-sulfotransferase 2
    carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
    galactose/N-acetylglucosamine/N-acetylgalactosamine 6-O-sulfotransferase 3
    galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3
    glcNAc6ST-2
    gn6st-2
    high endothelial cells N-acetylglucosamine 6-O-sulfotransferase
    NP_001159867.1
    NP_005760.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029801.1 RefSeqGene

      Range
      5307..17629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001166395.2NP_001159867.1  carbohydrate sulfotransferase 4

      See identical proteins and their annotated locations for NP_001159867.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC010547, BC035282, DA045171
      Consensus CDS
      CCDS10902.1
      UniProtKB/Swiss-Prot
      Q8IV46, Q8NCG5, Q9Y5R3
      Related
      ENSP00000441204.3, ENST00000539698.4
      Conserved Domains (1) summary
      cl21551
      Location:168358
      Sulfotransfer_1; Sulfotransferase domain
    2. NM_005769.2NP_005760.1  carbohydrate sulfotransferase 4

      See identical proteins and their annotated locations for NP_005760.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AC010547, AF131235, BC035282, DA496702
      Consensus CDS
      CCDS10902.1
      UniProtKB/Swiss-Prot
      Q8IV46, Q8NCG5, Q9Y5R3
      Related
      ENSP00000341206.5, ENST00000338482.5
      Conserved Domains (1) summary
      cl21551
      Location:168358
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      71526120..71538748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      77343320..77355947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)