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    ARPC2 actin related protein 2/3 complex subunit 2 [ Homo sapiens (human) ]

    Gene ID: 10109, updated on 5-Sep-2021

    Summary

    Official Symbol
    ARPC2provided by HGNC
    Official Full Name
    actin related protein 2/3 complex subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:705
    See related
    Ensembl:ENSG00000163466 MIM:604224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARC34; PRO2446; p34-Arc; PNAS-139
    Summary
    This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 92.4), bone marrow (RPKM 89.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ARPC2 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (218217138..218254348)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219081912..219119071)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 pseudogene 9 Neighboring gene uncharacterized LOC101928487 Neighboring gene tRNA-Tyr (anticodon ATA) 1-1 Neighboring gene G protein-coupled bile acid receptor 1 Neighboring gene angio associated migratory cell protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    GeneReviews: Not available
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env M-tropic HIV-1 gp120 enhances the binding of WASp and the actin-related protein 2/3 complex with beta-actin, an interaction essential for the proper formation of podosomes in immature monocyte-derived dendritic cells PubMed
    env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced association of LSP1, Wiskott-Aldrich Syndrome protein (WASp), Actin-Related Protein 2/3 (Arp2/3), and beta-actin in immature monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Arp2/3 protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in muscle cell projection membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    actin-related protein 2/3 complex subunit 2
    Names
    ARP2/3 protein complex subunit 34
    actin related protein 2/3 complex, subunit 2, 34kDa
    arp2/3 complex 34 kDa subunit
    testis tissue sperm-binding protein Li 53e

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005731.3NP_005722.1  actin-related protein 2/3 complex subunit 2

      See identical proteins and their annotated locations for NP_005722.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AF006085, CN291458
      Consensus CDS
      CCDS2410.1
      UniProtKB/Swiss-Prot
      O15144
      UniProtKB/TrEMBL
      Q53R19
      Related
      ENSP00000295685.10, ENST00000295685.14
      Conserved Domains (1) summary
      pfam04045
      Location:57284
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
    2. NM_152862.3NP_690601.1  actin-related protein 2/3 complex subunit 2

      See identical proteins and their annotated locations for NP_690601.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK290268, BG282181, CN291458
      Consensus CDS
      CCDS2410.1
      UniProtKB/Swiss-Prot
      O15144
      UniProtKB/TrEMBL
      Q53R19
      Related
      ENSP00000327137.5, ENST00000315717.10
      Conserved Domains (1) summary
      pfam04045
      Location:57284
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      218217138..218254348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017003113.1XP_016858602.1  actin-related protein 2/3 complex subunit 2 isoform X1

      Conserved Domains (1) summary
      pfam04045
      Location:2229
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
    2. XM_017003114.1XP_016858603.1  actin-related protein 2/3 complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A024R408
      Conserved Domains (1) summary
      pfam04045
      Location:1170
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
    3. XM_017003115.2XP_016858604.1  actin-related protein 2/3 complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A024R408
      Conserved Domains (1) summary
      pfam04045
      Location:1170
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
    4. XM_024452509.1XP_024308277.1  actin-related protein 2/3 complex subunit 2 isoform X2

      Conserved Domains (1) summary
      pfam04045
      Location:1170
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
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