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    SCAMP2 secretory carrier membrane protein 2 [ Homo sapiens (human) ]

    Gene ID: 10066, updated on 25-Nov-2021

    Summary

    Official Symbol
    SCAMP2provided by HGNC
    Official Full Name
    secretory carrier membrane protein 2provided by HGNC
    Primary source
    HGNC:HGNC:10564
    See related
    Ensembl:ENSG00000140497 MIM:606912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in colon (RPKM 41.0), small intestine (RPKM 37.7) and 25 other tissues See more
    Orthologs
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    Genomic context

    See SCAMP2 in Genome Data Viewer
    Location:
    15q24.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74843730..74873365, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75136071..75165706, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370897 Neighboring gene complexin 3 Neighboring gene microRNA 6882 Neighboring gene unc-51 like kinase 3 Neighboring gene mannose phosphate isomerase Neighboring gene family with sequence similarity 219 member B Neighboring gene cytochrome c oxidase subunit 5A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in post-Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    secretory carrier-associated membrane protein 2
    Names
    testis secretory sperm-binding protein Li 219p

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320778.2NP_001307707.1  secretory carrier-associated membrane protein 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC091230, AK291884, CD300387, R59393
      UniProtKB/TrEMBL
      A8K769
      Conserved Domains (1) summary
      pfam04144
      Location:160336
      SCAMP; SCAMP family
    2. NM_005697.5NP_005688.2  secretory carrier-associated membrane protein 2 isoform 2

      See identical proteins and their annotated locations for NP_005688.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a exon in the central coding region compared to variant 1. The encoded isoform (2) is sorter than isoform 2.
      Source sequence(s)
      AC091230, BC004385, R59393
      Consensus CDS
      CCDS10271.1
      UniProtKB/Swiss-Prot
      O15127
      UniProtKB/TrEMBL
      A0A140VK92
      Related
      ENSP00000268099.9, ENST00000268099.13
      Conserved Domains (1) summary
      pfam04144
      Location:117293
      SCAMP; SCAMP family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      74843730..74873365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021856.1XP_016877345.1  secretory carrier-associated membrane protein 2 isoform X1

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