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    AP1M2 adaptor related protein complex 1 subunit mu 2 [ Homo sapiens (human) ]

    Gene ID: 10053, updated on 8-Jul-2021

    Summary

    Official Symbol
    AP1M2provided by HGNC
    Official Full Name
    adaptor related protein complex 1 subunit mu 2provided by HGNC
    Primary source
    HGNC:HGNC:558
    See related
    Ensembl:ENSG00000129354 MIM:607309
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    mu2; MU1B; MU-1B; HSMU1B; AP1-mu2
    Summary
    This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in thyroid (RPKM 36.9), duodenum (RPKM 29.9) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See AP1M2 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10572671..10587315, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10683347..10697988, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene autophagy related 4D cysteine peptidase Neighboring gene KRI1 homolog Neighboring gene cyclin dependent kinase inhibitor 2D Neighboring gene LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) pseudogene Neighboring gene solute carrier family 44 member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env The highly conserved C-terminal dileucine motif (residues 851-856) in the cytosolic domain of HIV-1 gp41 interacts with clathrin-associated AP-1 adaptor complexes PubMed
    env A Tyr-based motif YXXO (residues 712-715) in the cytoplasmic domain of HIV-1 gp41 interacts with the micro1 and micro2 subunits of AP complexes PubMed
    env The cytoplasmic domain (residues 707-856) of HIV-1 gp41 interacts with whole clathrin-associated AP-1 and AP-2 adaptor complexes PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein targeting TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in vesicle targeting TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lysosomal membrane TAS
    Traceable Author Statement
    more info
     
    located_in trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    AP-1 complex subunit mu-2
    Names
    AP-mu chain family member mu1B
    HA1 47 kDa subunit 2
    adaptor protein complex AP-1 mu-2 subunit
    adaptor related protein complex 1 mu 2 subunit
    clathrin assembly protein complex 1 mu-2 medium chain 2
    clathrin coat assembly protein AP47 2
    clathrin coat associated protein AP47 2
    clathrin-associated adaptor medium chain mu2
    golgi adaptor AP-1 47 kDa protein
    golgi adaptor HA1/AP1 adaptin mu-2 subunit
    mu-adaptin 2
    mu1B-adaptin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300887.2NP_001287816.1  AP-1 complex subunit mu-2 isoform 1

      See identical proteins and their annotated locations for NP_001287816.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK222946, AW370781, BC003387, BC005021
      Consensus CDS
      CCDS77234.1
      UniProtKB/Swiss-Prot
      Q9Y6Q5
      UniProtKB/TrEMBL
      Q53GI5
      Related
      ENSP00000465685.1, ENST00000590923.5
      Conserved Domains (2) summary
      cl02092
      Location:5137
      Clat_adaptor_s; Clathrin adaptor complex small chain
      cl10970
      Location:154423
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    2. NM_005498.5NP_005489.2  AP-1 complex subunit mu-2 isoform 2

      See identical proteins and their annotated locations for NP_005489.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AF020797, BC005021, BE044092
      Consensus CDS
      CCDS45964.1
      UniProtKB/Swiss-Prot
      Q9Y6Q5
      Related
      ENSP00000250244.5, ENST00000250244.11
      Conserved Domains (2) summary
      cl02092
      Location:5137
      Clat_adaptor_s; Clathrin adaptor complex small chain
      cl10970
      Location:154421
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      10572671..10587315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451304.1XP_024307072.1  AP-1 complex subunit mu-2 isoform X2

      Conserved Domains (1) summary
      cd09259
      Location:234503
      AP-1_Mu1B_Cterm; C-terminal domain of medium Mu1B subunit in epithelial cell-specific clathrin-associated adaptor protein (AP) complex AP-1
    2. XM_024451303.1XP_024307071.1  AP-1 complex subunit mu-2 isoform X1

      Conserved Domains (1) summary
      cd09259
      Location:234501
      AP-1_Mu1B_Cterm; C-terminal domain of medium Mu1B subunit in epithelial cell-specific clathrin-associated adaptor protein (AP) complex AP-1
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