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    PARP2 poly(ADP-ribose) polymerase 2 [ Homo sapiens (human) ]

    Gene ID: 10038, updated on 9-Aug-2021

    Summary

    Official Symbol
    PARP2provided by HGNC
    Official Full Name
    poly(ADP-ribose) polymerase 2provided by HGNC
    Primary source
    HGNC:HGNC:272
    See related
    Ensembl:ENSG00000129484 MIM:607725
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2
    Summary
    This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 14.3), testis (RPKM 13.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PARP2 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (20343041..20357904)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20811794..20826063)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene cyclin B1 interacting protein 1 Neighboring gene small nucleolar RNA, H/ACA box 79B Neighboring gene small nucleolar RNA, C/D box 126 Neighboring gene ribonuclease P RNA component H1 Neighboring gene telomerase associated protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 382

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD DNA ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NAD+ ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein ADP-ribosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein ADP-ribosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in site of DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    poly [ADP-ribose] polymerase 2
    Names
    ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2
    ADP-ribosyltransferase diphtheria toxin-like 2
    ADPRT-2
    DNA ADP-ribosyltransferase PARP2
    NAD(+) ADP-ribosyltransferase 2
    hPARP-2
    poly (ADP-ribose) polymerase family, member 2
    poly (ADP-ribosyl) transferase-like 2
    poly[ADP-ribose] synthase 2
    poly[ADP-ribose] synthetase 2
    protein poly-ADP-ribosyltransferase PARP2
    NP_001036083.1
    NP_005475.2
    XP_005267304.1
    XP_016876401.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033959.1 RefSeqGene

      Range
      5001..19291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042618.2NP_001036083.1  poly [ADP-ribose] polymerase 2 isoform 2

      See identical proteins and their annotated locations for NP_001036083.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 5' coding region, as compared to variant 1. The reading frame is not changed but the transcript encodes 13 aa less than variant 1.
      Source sequence(s)
      AJ236912, BU541261, DA354586
      Consensus CDS
      CCDS45077.1
      UniProtKB/Swiss-Prot
      Q9UGN5
      Related
      ENSP00000392972.3, ENST00000429687.8
      Conserved Domains (1) summary
      cl27333
      Location:52566
      PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain
    2. NM_005484.4NP_005475.2  poly [ADP-ribose] polymerase 2 isoform 1

      See identical proteins and their annotated locations for NP_005475.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a longer isoform (1).
      Source sequence(s)
      AJ236912, AK001980, BU541261, DA354586
      Consensus CDS
      CCDS41910.1
      UniProtKB/Swiss-Prot
      Q9UGN5
      Related
      ENSP00000250416.5, ENST00000250416.9
      Conserved Domains (3) summary
      cd08003
      Location:106208
      WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
      cd01437
      Location:231576
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:365577
      PARP; Poly(ADP-ribose) polymerase catalytic domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

      Range
      20343041..20357904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020912.1XP_016876401.1  poly [ADP-ribose] polymerase 2 isoform X2

      Conserved Domains (2) summary
      PLN03124
      Location:52476
      PLN03124; poly [ADP-ribose] polymerase; Provisional
      cd22252
      Location:1978
      PARP2_NTR; NTR (N-terminal region) domain of poly [ADP-ribose] polymerase 2 (PARP-2) and similar proteins
    2. XM_005267247.3XP_005267304.1  poly [ADP-ribose] polymerase 2 isoform X1

      Conserved Domains (2) summary
      cd08003
      Location:106208
      WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
      cd01437
      Location:231489
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
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