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    Mir9-1 microRNA 9-1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100313994, updated on 17-Aug-2024
    Official Symbol
    Mir9-1provided by RGD
    Official Full Name
    microRNA 9-1provided by RGD
    Primary source
    RGD:2325603
    See related
    miRBase:MI0000838; AllianceGenome:RGD:2325603
    Gene type
    ncRNA
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mir9a-1; rno-mir-9-1; rno-mir-9a-1
    Summary
    microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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    See Mir9-1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175974971..175975059)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173677139..173677227)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187582799..187582887)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene myocyte enhancer factor 2D Neighboring gene uncharacterized LOC102547113 Neighboring gene uncharacterized LOC100911992 Neighboring gene microRNA 3597-1 Neighboring gene Rh family B glycoprotein Neighboring gene uncharacterized LOC103691617

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. MicroRNA-9 mediated the protective effect of ferulic acid on hypoxic-ischemic brain damage in neonatal rats. Yao K, et al. PLoS One, 2020. PMID 32470970, Free PMC Article
    2. MicroRNA-9a-5p Alleviates Ischemia Injury After Focal Cerebral Ischemia of the Rat by Targeting ATG5-Mediated Autophagy. Wang N, et al. Cell Physiol Biochem, 2018. PMID 29316542
    3. Circular RNA VMA21 ameliorates sepsis-associated acute kidney injury by regulating miR-9-3p/SMG1/inflammation axis and oxidative stress. Shi Y, et al. J Cell Mol Med, 2020 Oct. PMID 32827242, Free PMC Article
    4. Requirement of miR-9-dependent regulation of Myocd in PASMCs phenotypic modulation and proliferation induced by hepatopulmonary syndrome rat serum. Xu D, et al. J Cell Mol Med, 2015 Oct. PMID 26147104, Free PMC Article
    5. MicroRNA signature of inflamed lymphatic endothelium and role of miR-9 in lymphangiogenesis and inflammation. Chakraborty S, et al. Am J Physiol Cell Physiol, 2015 Nov 15. PMID 26354749, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-9 facilitates hypoxia-induced injury and apoptosis in H9c2 cells via targeting CDK8.
      Title: MicroRNA-9 facilitates hypoxia-induced injury and apoptosis in H9c2 cells via targeting CDK8.
    2. Circular RNA VMA21 ameliorates sepsis-associated acute kidney injury by regulating miR-9-3p/SMG1/inflammation axis and oxidative stress.
      Title: Circular RNA VMA21 ameliorates sepsis-associated acute kidney injury by regulating miR-9-3p/SMG1/inflammation axis and oxidative stress.
    3. MicroRNA-9 ameliorates destructive arthritis through down-regulation of NF-kappaB1-RANKL pathway in fibroblast-like synoviocytes.
      Title: MicroRNA-9 ameliorates destructive arthritis through down-regulation of NF-κB1-RANKL pathway in fibroblast-like synoviocytes.
    4. MiR-9 facilitates cartilage regeneration of osteoarthritis in rabbits through regulating Notch signaling pathway.
      Title: MiR-9 facilitates cartilage regeneration of osteoarthritis in rabbits through regulating Notch signaling pathway.
    5. our findings indicate that Ferulic acid treatment may protect against neuronal death through the inhibition of miRNA-9 induction in the rat hippocampus following hypoxic-ischemic damage.
      Title: MicroRNA-9 mediated the protective effect of ferulic acid on hypoxic-ischemic brain damage in neonatal rats.
    6. miRs let-7 and miR-9 are involved in regulating neuron pathfinding and extend our understanding of the regulatory pathways active during peripheral nerve regeneration
      Title: The microRNAs let-7 and miR-9 down-regulate the axon-guidance genes Ntn1 and Dcc during peripheral nerve regeneration.
    7. MiR-9a-5p may play a critical role in regulating the process of autophagy by targeting ATG5 expression, and overexpression of miR-9a-5p may be a potential approach in alleviating ischemia injury induced by middle cerebral artery occlusion.
      Title: MicroRNA-9a-5p Alleviates Ischemia Injury After Focal Cerebral Ischemia of the Rat by Targeting ATG5-Mediated Autophagy.
    8. Microrna-9 was up-regulated in the spinal dorsal horn neurons of painful diabetic neuropathy animals compared to controls.
      Title: miR-9 Mediates CALHM1-Activated ATP-P2X7R Signal in Painful Diabetic Neuropathy Rats.
    9. miR-9 plays an important role in regulating the process of dementia induced by occlusion of the bilateral common carotid artery in rats by increasing BACE1 expression via downregulation of CREB.
      Title: MiR-9 Regulates the Expression of BACE1 in Dementia Induced by Chronic Brain Hypoperfusion in Rats.
    10. Fetal alcohol exposure increased the expression levels of miR-9, reduced levels of D2r and increased levels of Prl in the pituitary, and in plasma.
      Title: MicroRNA-9 regulates fetal alcohol-induced changes in D2 receptor to promote prolactin production.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Other Names

    • microRNA mir-9-1
    • microRNA mir-9a-1

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_031811.1 RNA Sequence

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      175974971..175975059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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