Format

Send to:

Choose Destination
    • Showing Current items.

    TSNAX-DISC1 TSNAX-DISC1 readthrough (NMD candidate) [ Homo sapiens (human) ]

    Gene ID: 100303453, updated on 17-Jun-2019

    Summary

    Official Symbol
    TSNAX-DISC1provided by HGNC
    Official Full Name
    TSNAX-DISC1 readthrough (NMD candidate)provided by HGNC
    Primary source
    HGNC:HGNC:49177
    See related
    Ensembl:ENSG00000270106
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene represents naturally occurring read-through transcription between the neighboring TSNAX (translin-associated factor X) and DISC1 (disrupted in schizophrenia 1) genes on chromosome 1. Alternative splicing results in multiple transcript variants, all of which are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. These alterations in gene processing may be associated with risk for psychiatric illness, most notably, schizophrenia. [provided by RefSeq, Nov 2010]
    Expression
    Ubiquitous expression in placenta (RPKM 3.7), brain (RPKM 2.9) and 25 other tissues See more

    Genomic context

    See TSNAX-DISC1 in Genome Data Viewer
    Location:
    1q42.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (231528653..232041272)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (231664399..232177018)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985360 Neighboring gene egl-9 family hypoxia inducible factor 1 Neighboring gene small nuclear ribonucleoprotein D2 pseudogene 2 Neighboring gene translin associated factor X Neighboring gene long intergenic non-protein coding RNA 582 Neighboring gene DISC1 scaffold protein Neighboring gene RNA, U5A small nuclear 5, pseudogene Neighboring gene uncharacterized LOC105373170 Neighboring gene disrupted in schizophrenia 2 Neighboring gene DISC1 intronic transcript 1 Neighboring gene uncharacterized LOC105373172 Neighboring gene uncharacterized LOC105373171

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.
    NHGRI GWA Catalog
    Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.
    NHGRI GWA Catalog
    Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes.
    NHGRI GWA Catalog
    Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_028393.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript, which is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
      Source sequence(s)
      FJ804217
    2. NR_028394.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 3' exons, but has two additional exons in the 5' and 3' regions respectively and an alternate 3' segment, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
      Source sequence(s)
      FJ804219
      Related
      ENST00000602962.5
    3. NR_028395.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several 3' exons, but has an additional exon in the 5' region, an alternate exon in the 3' region and an alternate 3' segment, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
      Source sequence(s)
      FJ804220
      Related
      ENST00000602567.1
    4. NR_028396.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks several 3' exons, but has an additional exon in the 3' region and an alternate 3' segment, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
      Source sequence(s)
      FJ804218
      Related
      ENST00000602634.5
    5. NR_028397.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) This variant (5) lacks an internal exon and several 3' exons, but has two additional exons in the 5' and 3' regions respectively and an alternate 3' segment, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
      Source sequence(s)
      FJ804221
      Related
      ENST00000602956.5
    6. NR_028398.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two internal exons in the 5' region and several 3' exons, but has two additional exons in the 5' and 3' regions respectively and an alternate 3' segment, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
      Source sequence(s)
      FJ804222
      Related
      ENST00000602885.5
    7. NR_028399.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks multiple 3' exons but has two additional exons in the 5' region and an alternate 3' segment, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
      Source sequence(s)
      FJ804224
    8. NR_028400.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks an internal exon and multiple 3' exons but has an additional exon in the 5' region and an alternate 3' segment, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
      Source sequence(s)
      FJ804223
      Related
      ENST00000647072.1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      231528653..232041272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center