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    ZNF587B zinc finger protein 587B [ Homo sapiens (human) ]

    Gene ID: 100293516, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF587Bprovided by HGNC
    Official Full Name
    zinc finger protein 587Bprovided by HGNC
    Primary source
    HGNC:HGNC:37142
    See related
    Ensembl:ENSG00000269343 AllianceGenome:HGNC:37142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 3.0), skin (RPKM 2.7) and 25 other tissues See more
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    Genomic context

    See ZNF587B in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57830299..57846238)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60927216..60943143)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58341667..58357606)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58322897-58323548 Neighboring gene zinc finger protein 552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:58333533-58334033 Neighboring gene FKBP prolyl isomerase 1A pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15167 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:58361669-58362868 Neighboring gene uncharacterized LOC124904782 Neighboring gene zinc finger protein 587 Neighboring gene ubiquitin conjugating enzyme E2 C pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: ZNF587

    Clone Names

    • FLJ16599, FLJ52732, FLJ52828

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204818.2NP_001191747.1  zinc finger protein 587B isoform 2

      See identical proteins and their annotated locations for NP_001191747.1

      Status: VALIDATED

      Source sequence(s)
      AC010522, AK299091, CA427231, DB065500
      Consensus CDS
      CCDS56109.1
      UniProtKB/Swiss-Prot
      B4DR41, E7ETH6
      Related
      ENSP00000392410.2, ENST00000442832.8
      Conserved Domains (5) summary
      smart00349
      Location:1556
      KRAB; krueppel associated box
      COG5048
      Location:163372
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272292
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1554
      KRAB; KRAB box
      pfam13465
      Location:340365
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001376223.1NP_001363152.1  zinc finger protein 587B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010522
      Consensus CDS
      CCDS92699.1
      UniProtKB/TrEMBL
      M0QY62
      Related
      ENSP00000469623.1, ENST00000594901.2
      Conserved Domains (4) summary
      COG5048
      Location:215504
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:552572
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1555
      KRAB; KRAB box
      pfam13465
      Location:564588
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57830299..57846238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60927216..60943143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)