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    FRAT1 FRAT regulator of WNT signaling pathway 1 [ Homo sapiens (human) ]

    Gene ID: 10023, updated on 14-Aug-2021

    Summary

    Official Symbol
    FRAT1provided by HGNC
    Official Full Name
    FRAT regulator of WNT signaling pathway 1provided by HGNC
    Primary source
    HGNC:HGNC:3944
    See related
    Ensembl:ENSG00000165879 MIM:602503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]
    Orthologs
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    Genomic context

    See FRAT1 in Genome Data Viewer
    Location:
    10q24.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (97319271..97321915)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99079028..99081672)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ARHGAP19-SLIT1 readthrough (NMD candidate) Neighboring gene uncharacterized LOC105378447 Neighboring gene Rho GTPase activating protein 19 Neighboring gene Sharpr-MPRA regulatory region 7927 Neighboring gene ribosomal protein L12 pseudogene 27 Neighboring gene uncharacterized LOC105378448 Neighboring gene FRAT regulator of WNT signaling pathway 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ97193

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    proto-oncogene FRAT1
    Names
    FRAT-1
    FRAT1, WNT signaling pathway regulator
    frequently rearranged in advanced T-cell lymphomas 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005479.4NP_005470.2  proto-oncogene FRAT1

      See identical proteins and their annotated locations for NP_005470.2

      Status: REVIEWED

      Source sequence(s)
      AL355490
      Consensus CDS
      CCDS7455.1
      UniProtKB/Swiss-Prot
      Q92837
      Related
      ENSP00000360060.3, ENST00000371021.5
      Conserved Domains (1) summary
      pfam05350
      Location:1239
      GSK-3_bind; Glycogen synthase kinase-3 binding

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      97319271..97321915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181355.1: Suppressed sequence

      Description
      NM_181355.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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