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    TSTD1 thiosulfate sulfurtransferase like domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 100131187, updated on 17-Jun-2019

    Summary

    Official Symbol
    TSTD1provided by HGNC
    Official Full Name
    thiosulfate sulfurtransferase like domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:35410
    See related
    Ensembl:ENSG00000215845 MIM:616041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAT; TST
    Expression
    Ubiquitous expression in prostate (RPKM 33.0), kidney (RPKM 26.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See TSTD1 in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161037631..161038964, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161007418..161008887, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928372 Neighboring gene intelectin 2 Neighboring gene F11 receptor Neighboring gene upstream transcription factor 1 Neighboring gene Rho GTPase activating protein 30

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    thiosulfate-thiol sulfurtransferase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    sulfide oxidation, using sulfide:quinone oxidoreductase TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    thiosulfate:glutathione sulfurtransferase
    Names
    putative thiosulfate sulfurtransferase KAT
    thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
    thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1
    NP_001106676.1
    NP_001106677.1
    NP_001106678.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113205.2NP_001106676.1  thiosulfate:glutathione sulfurtransferase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region that results in a frameshift and premature stop codon, compared to variant 1. The encoded protein (isoform 3) has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AV688621, BC001699
      Consensus CDS
      CCDS44258.1
      UniProtKB/Swiss-Prot
      Q8NFU3
      Related
      ENSP00000325518.10, ENST00000318289.14
      Conserved Domains (1) summary
      cl00125
      Location:7101
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
    2. NM_001113206.2NP_001106677.1  thiosulfate:glutathione sulfurtransferase isoform 2

      See identical proteins and their annotated locations for NP_001106677.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, that results a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AV688621, CD675389
      Consensus CDS
      CCDS44257.1
      UniProtKB/Swiss-Prot
      Q8NFU3
      Related
      ENSP00000357003.1, ENST00000368024.5
      Conserved Domains (1) summary
      cl00125
      Location:471
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
    3. NM_001113207.2NP_001106678.1  thiosulfate:glutathione sulfurtransferase isoform 1

      See identical proteins and their annotated locations for NP_001106678.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      CD675389
      Consensus CDS
      CCDS53400.1
      UniProtKB/Swiss-Prot
      Q8NFU3
      Related
      ENSP00000388293.2, ENST00000423014.3
      Conserved Domains (1) summary
      cl00125
      Location:7112
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      161037631..161038964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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