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    MMP1 matrix metallopeptidase 1 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100009110, updated on 2-Dec-2024
    Gene symbol
    MMP1
    Gene description
    matrix metallopeptidase 1
    See related
    Ensembl:ENSOCUG00000017958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    MMP-1
    Orthologs
    human all
    NEW
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    See MMP1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 1 NC_091432.1 (94498421..94507957, complement)
    RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 1 NC_067374.1 (127682148..127691689)

    Chromosome 1 - NC_091432.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 14C pseudogene Neighboring gene matrix metallopeptidase 10 Neighboring gene eukaryotic initiation factor 4A-II pseudogene Neighboring gene matrix metallopeptidase 3 Neighboring gene matrix metallopeptidase 12

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. src-related tyrosine kinases regulate transcriptional activation of the interstitial collagenase gene, MMP-1, in interleukin-1-stimulated synovial fibroblasts. Vincenti MP, et al. Arthritis Rheum, 1996 Apr. PMID 8630105
    2. Characterization of rabbit genes for synovial cell collagenase. Fini ME, et al. Arthritis Rheum, 1986 Nov. PMID 3022758
    3. Homology between exon-containing portions of rabbit genomic clones for synovial cell collagenase and human foreskin and synovial cell mRNAs. Fini ME, et al. Coll Relat Res, 1986 Jul. PMID 3021384
    4. A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases that degrade the connective tissue matrix. Fini ME, et al. Biochemistry, 1987 Sep 22. PMID 2825772
    5. The morphology and histology study on rabbit degenerated medial meniscus after posterior cruciate ligament rupture. Deng Z, et al. Biosci Rep, 2019 Jan 31. PMID 30626725, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. There were clear time-dependent degenerative changes in the histology of the medial meniscus after PCL rupture. The high expression of TIMP-1, MMP-1 and MMP-13 in the cartilage may be responsible for the degeneration, and PCL rupture may trigger meniscus degradation and ultimately osteoarthritis
      Title: The morphology and histology study on rabbit degenerated medial meniscus after posterior cruciate ligament rupture.
    2. These results suggest that PEP-1-SIRT2 promotes matrix metalloproteinases-induced dedifferentiation via ERK signaling in articular chondrocytes. .
      Title: PEP-1-SIRT2-induced matrix metalloproteinase-1 and -13 modulates type II collagen expression via ERK signaling in rabbit articular chondrocytes.
    3. the total content and active forms of matrix metalloproteinases (MMPs)-1, -3, and -13 was measured to assess the potential role of the mechanical environment in regulation of matrix turnover by ligament fibroblasts.
      Title: Characterization of total and active matrix metalloproteinases-1, -3, and -13 synthesized and secreted by anterior cruciate ligament fibroblasts in three-dimensional collagen gels.
    4. Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 and decreased TIMP-3 secretion.
      Title: Cigarette smoke components induce matrix metalloproteinase-1 in aortic endothelial cells through inhibition of mTOR signaling.
    Submit: New GeneRIF Correction

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    interstitial collagenase
    Names
    collagenase-1
    matrix metallopeptidase 1 (interstitial collagenase)
    matrix metalloproteinase-1
    NP_001164610.1

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171139.2 → NP_001164610.1  interstitial collagenase precursor

      See identical proteins and their annotated locations for NP_001164610.1

      Status: VALIDATED

      Source sequence(s)
      AAGW02009043
      UniProtKB/Swiss-Prot
      P13943
      UniProtKB/TrEMBL
      A0A5F9CRQ6
      Related
      ENSOCUP00000015428.3, ENSOCUT00000017958.4
      Conserved Domains (4) summary
      cd00094
      Location:274 → 465
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:107 → 260
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:107 → 260
      Peptidase_M10; Matrixin
      pfam01471
      Location:26 → 86
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mOryCun1.1

    Genomic

    1. NC_091432.1 Reference mOryCun1.1

      Range
      94498421..94507957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13943.1 GenPept UniProtKB/Swiss-Prot:P13943

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials